Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 6099863..6100530 Replicon chromosome
Accession NZ_CP014158
Organism Pseudomonas citronellolis strain P3B5

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A127N020
Locus tag PcP3B5_RS26725 Protein ID WP_061562837.1
Coordinates 6100120..6100530 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID W5ISS6
Locus tag PcP3B5_RS26720 Protein ID WP_009613156.1
Coordinates 6099863..6100123 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PcP3B5_RS26695 6095142..6095384 - 243 WP_009613144.1 YdcH family protein -
PcP3B5_RS26700 6095575..6095988 + 414 WP_043268871.1 large-conductance mechanosensitive channel protein MscL -
PcP3B5_RS26705 6096006..6097559 - 1554 WP_058070083.1 TerC family protein -
PcP3B5_RS26710 6097751..6098527 - 777 WP_061562836.1 ferredoxin--NADP reductase -
PcP3B5_RS26715 6098656..6099780 + 1125 WP_061563339.1 class I SAM-dependent methyltransferase -
PcP3B5_RS26720 6099863..6100123 + 261 WP_009613156.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PcP3B5_RS26725 6100120..6100530 + 411 WP_061562837.1 type II toxin-antitoxin system VapC family toxin Toxin
PcP3B5_RS26730 6101140..6101715 - 576 WP_061562838.1 nucleotidyltransferase family protein -
PcP3B5_RS26735 6101712..6102680 - 969 WP_061562839.1 XdhC family protein -
PcP3B5_RS26740 6102682..6103917 - 1236 WP_061562840.1 cytochrome c -
PcP3B5_RS26745 6103920..6104453 - 534 WP_009613171.1 (2Fe-2S)-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

SpoVT-AbrB domain

(11-49)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15406.70 Da        Isoelectric Point: 7.7739

>T60311 WP_061562837.1 NZ_CP014158:6100120-6100530 [Pseudomonas citronellolis]
VKYLLDTNILIYLLKNRPESVARRVNALPADAGLCMSFFTYAELLKGAERSTRRSEVLRQLERLTRQVTVVYDGTPRLCE
HYATQFTRLKLAGTPIGANDLRIACHALALEATLVTHNTREFERIDGLSLEDWAAE

Download         Length: 411 bp

>T60311 NZ_CP014158:6100120-6100530 [Pseudomonas citronellolis]
GTGAAATACCTGCTCGACACCAACATCCTCATCTACCTGCTGAAGAACCGCCCGGAATCCGTGGCCCGACGGGTCAACGC
CCTGCCCGCCGACGCCGGCCTGTGCATGTCCTTCTTCACCTACGCCGAACTGCTCAAGGGCGCCGAACGCAGCACCCGGC
GCAGCGAGGTCCTGCGCCAGCTGGAGCGCCTGACGCGCCAGGTGACGGTGGTCTACGACGGCACTCCGCGCCTGTGCGAG
CACTACGCGACGCAGTTCACCCGCCTAAAGCTGGCCGGCACGCCGATCGGCGCCAACGACCTGAGGATCGCCTGCCACGC
CCTGGCGCTGGAGGCGACCCTGGTGACGCACAACACTCGCGAGTTCGAACGCATCGACGGGCTGAGCCTGGAAGATTGGG
CGGCCGAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9789.91 Da        Isoelectric Point: 4.2182

>AT60311 WP_009613156.1 NZ_CP014158:6099863-6100123 [Pseudomonas citronellolis]
MSSPTLPSRVFMNGNSQAVRIPQEFRLDASRVEIRRQANGDLVIHPLPEDRGEALLQALSGFDDEFIEALEEGQREQPPM
QEREEL

Download         Length: 261 bp

>AT60311 NZ_CP014158:6099863-6100123 [Pseudomonas citronellolis]
ATGTCTTCGCCCACACTCCCCAGCCGCGTCTTCATGAACGGCAACAGCCAGGCGGTGCGCATTCCCCAGGAGTTCCGCCT
GGACGCCAGCCGCGTGGAAATCCGCCGCCAGGCCAATGGCGACCTGGTCATCCACCCGCTGCCCGAGGACCGCGGCGAGG
CGTTGCTGCAGGCGCTGTCCGGCTTCGACGACGAGTTCATCGAAGCACTGGAAGAAGGGCAGCGCGAACAGCCGCCGATG
CAGGAGCGGGAAGAGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127N020

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5D6X2

References