Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 5124068..5125207 Replicon chromosome
Accession NZ_CP014158
Organism Pseudomonas citronellolis strain P3B5

Toxin (Protein)


Gene name - Uniprot ID A0A1S1GKD1
Locus tag PcP3B5_RS22275 Protein ID WP_043271092.1
Coordinates 5124068..5124838 (-) Length 257 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1A5D9R9
Locus tag PcP3B5_RS22280 Protein ID WP_043271094.1
Coordinates 5124839..5125207 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PcP3B5_RS22260 5120678..5121565 + 888 WP_043271086.1 metal-dependent hydrolase -
PcP3B5_RS22265 5121897..5123261 - 1365 WP_162493543.1 DNA recombination protein RmuC -
PcP3B5_RS22270 5123786..5123992 - 207 WP_043271090.1 hypothetical protein -
PcP3B5_RS22275 5124068..5124838 - 771 WP_043271092.1 RES family NAD+ phosphorylase Toxin
PcP3B5_RS22280 5124839..5125207 - 369 WP_043271094.1 DUF2384 domain-containing protein Antitoxin
PcP3B5_RS22285 5125486..5125920 + 435 WP_043271560.1 RcnB family protein -
PcP3B5_RS22290 5125927..5126358 - 432 WP_043271096.1 hypothetical protein -
PcP3B5_RS22295 5126487..5126969 + 483 WP_043271098.1 GreA/GreB family elongation factor -
PcP3B5_RS22300 5127041..5127382 + 342 WP_009620588.1 carboxymuconolactone decarboxylase family protein -
PcP3B5_RS22305 5127475..5127846 + 372 WP_043271100.1 hypothetical protein -
PcP3B5_RS22310 5127834..5128883 - 1050 WP_043315592.1 diguanylate cyclase -
PcP3B5_RS22315 5129177..5130013 + 837 WP_043271102.1 5'-nucleotidase, lipoprotein e(P4) family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(69-212)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(71-120)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 28890.08 Da        Isoelectric Point: 7.0428

>T60310 WP_043271092.1 NZ_CP014158:c5124838-5124068 [Pseudomonas citronellolis]
MALDAGAELWRECRGEQVIAPLRGKLVRLVESQEQVATLQLVDTLEEQALLEELIETSKPHLPPSTETLHYLLKTPFRYP
PLRWGSRFGRRHEPSLFYAALRLETAMAEAAYYRFVLWEGMASPPPSGRILSEHASFEARFQVQRGIRLQAPPFDSYAER
LQDPRDYRLTQALGSAMRAAAVEAFEYRSARCPEGGLNAALFVPSAFVDKRPRNLMPWLCETTADYVAFKHAQVPGAPRL
FPRAGFLVEGDLPHPA

Download         Length: 771 bp

>T60310 NZ_CP014158:c5124838-5124068 [Pseudomonas citronellolis]
ATGGCCCTCGACGCCGGCGCCGAACTGTGGCGCGAATGCCGGGGCGAGCAGGTCATAGCCCCGCTGCGGGGCAAGCTGGT
GCGCCTGGTGGAGAGCCAGGAGCAGGTCGCGACCCTGCAACTGGTGGATACCCTGGAGGAGCAGGCCCTGCTGGAAGAGC
TGATCGAGACCAGCAAGCCGCACCTGCCGCCGTCCACCGAAACCCTGCACTACCTGCTCAAGACGCCGTTCCGCTACCCG
CCGCTGCGCTGGGGCTCGCGCTTCGGCCGCCGCCACGAACCCAGCCTGTTCTACGCCGCGTTGCGCCTGGAGACGGCCAT
GGCCGAGGCGGCCTATTACCGCTTCGTGCTCTGGGAGGGGATGGCCAGCCCGCCGCCCAGCGGGCGCATCCTTTCCGAGC
ACGCTTCTTTCGAGGCGCGTTTCCAGGTGCAACGGGGCATACGCCTGCAGGCGCCGCCCTTCGACAGCTATGCCGAGCGC
CTGCAGGACCCGCGGGACTACCGCCTGACCCAGGCGCTGGGCAGCGCCATGCGCGCTGCCGCGGTGGAGGCCTTCGAATA
CCGCTCGGCGCGCTGCCCGGAAGGTGGGCTGAATGCCGCGCTCTTCGTGCCTTCGGCCTTCGTCGACAAGCGCCCGCGCA
ACCTCATGCCCTGGCTGTGCGAGACCACCGCCGACTACGTGGCCTTCAAGCATGCCCAGGTGCCGGGGGCGCCGCGGCTG
TTCCCGCGCGCGGGATTCCTGGTCGAGGGCGACCTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13395.70 Da        Isoelectric Point: 10.8284

>AT60310 WP_043271094.1 NZ_CP014158:c5125207-5124839 [Pseudomonas citronellolis]
MSALIRETPSADLVLAKAVLAAREQLGMTQQELAAIVGVDRSAVSRWKSGGLRVGSKTGELALLLVRVYRALFALFGGNL
EDMRHFLRTPNRHLSGVPLQRMEQVQGLVQVVEYLDAIRGKI

Download         Length: 369 bp

>AT60310 NZ_CP014158:c5125207-5124839 [Pseudomonas citronellolis]
ATGAGCGCACTGATCCGGGAAACTCCGTCGGCTGATCTGGTCCTGGCCAAGGCGGTACTGGCTGCCCGTGAGCAACTGGG
CATGACGCAGCAGGAGCTGGCCGCCATCGTCGGCGTCGACCGCAGCGCGGTGAGCCGCTGGAAGAGCGGCGGCCTGCGGG
TGGGCAGCAAGACCGGCGAGCTGGCGCTGCTGCTGGTGCGGGTATACCGCGCGCTCTTCGCCCTGTTCGGCGGCAACCTG
GAGGACATGCGCCACTTCCTGCGCACCCCCAACCGCCACCTGAGCGGTGTGCCGCTGCAGCGGATGGAGCAGGTGCAGGG
CCTGGTGCAGGTGGTCGAGTACCTCGACGCCATCCGGGGCAAGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S1GKD1

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5D9R9

References