Detailed information of TA system TA060305

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 2866988..2867880
• Replicon: chromosome
• Accession: NZ_CP014158
• Organism: Pseudomonas citronellolis strain P3B5

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: A0A127MRU9
• Locus tag: PcP3B5_RS12675
• Protein ID: WP_061561439.1
• Coordinates: 2867356..2867880 (+)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: A0A127MSF5
• Locus tag: PcP3B5_RS12670
• Protein ID: WP_061561438.1
• Coordinates: 2866988..2867359 (+)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PcP3B5_RS12650	2862393..2863655	-	1263	WP_061561434.1	ATP-grasp domain-containing protein	-
PcP3B5_RS12655	2863673..2864848	-	1176	WP_061561435.1	MFS transporter	-
PcP3B5_RS12660	2864845..2866146	-	1302	WP_061561436.1	lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein	-
PcP3B5_RS12665	2866613..2866810	-	198	WP_061561437.1	hypothetical protein	-
PcP3B5_RS12670	2866988..2867359	+	372	WP_061561438.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
PcP3B5_RS12675	2867356..2867880	+	525	WP_061561439.1	RES family NAD+ phosphorylase	Toxin
PcP3B5_RS12680	2867893..2870730	-	2838	WP_061561440.1	conjugative transfer ATPase	-
PcP3B5_RS31415	2870934..2871311	-	378	WP_145923896.1	hypothetical protein	-
PcP3B5_RS31420	2871552..2872328	-	777	WP_145923897.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2807159..3044816	237657

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (14-168)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-120)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 19130.47 Da
• Isoelectric Point: 4.3033

>T60305 WP_061561439.1 NZ_CP014158:2867356-2867880 [Pseudomonas citronellolis]
MISKMLGADGDEAFYRVIVPAYAGTPLSGMGAARQGGRFNRPDQEALYLALDESTALAEYKQDNPWLRPGTICTFFVNGL
RVADLSAGFDPDHWPPLWADYTVDWRAEWFDKSVEPPTWYMADDVVAAGLDGILFPSQARPGGANLVIYSSSSRPAAQLR
VYDPDGALQRLTPQ

Nucleotide

• Length: 525 bp

>T60305 NZ_CP014158:2867356-2867880 [Pseudomonas citronellolis]
ATGATCTCGAAGATGCTCGGCGCCGACGGCGACGAGGCCTTTTACCGAGTCATCGTGCCGGCTTATGCCGGCACACCCTT
GTCCGGGATGGGGGCGGCGCGCCAGGGAGGGCGGTTCAACCGTCCGGACCAGGAGGCGTTGTACCTGGCACTGGATGAGT
CGACGGCGTTGGCCGAATACAAGCAGGACAACCCGTGGCTACGTCCCGGCACGATCTGCACGTTCTTCGTCAACGGCCTG
CGCGTCGCTGACTTGAGCGCCGGTTTCGATCCGGATCACTGGCCGCCGCTCTGGGCCGACTACACGGTGGACTGGCGAGC
GGAGTGGTTCGACAAGTCGGTCGAGCCGCCCACTTGGTACATGGCTGACGACGTGGTCGCTGCTGGGCTGGACGGCATTC
TGTTCCCTTCGCAGGCAAGGCCGGGTGGAGCCAACCTGGTGATCTATAGCAGCTCGTCCCGGCCTGCGGCGCAACTGCGT
GTCTATGATCCGGACGGAGCCCTGCAGCGCTTGACTCCTCAGTGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13768.66 Da
• Isoelectric Point: 7.2024

>AT60305 WP_061561438.1 NZ_CP014158:2866988-2867359 [Pseudomonas citronellolis]
MNTVLQEPFVERFREPNTPYLSPSKVGDFFGFRVQELAERAHVHRNTPTARPQAPQLQKYLQDMVRVLAVATEMTGDVQR
AVFLLRNEPLRAFGYKTADTLIQEGRADAVIAYLESFAGGAAG

Nucleotide

• Length: 372 bp

>AT60305 NZ_CP014158:2866988-2867359 [Pseudomonas citronellolis]
ATGAATACTGTGCTGCAAGAACCCTTTGTCGAGCGGTTCCGCGAGCCCAACACGCCCTACCTGTCTCCGTCTAAGGTCGG
TGACTTCTTTGGCTTCCGGGTCCAGGAGTTGGCCGAGCGCGCTCACGTGCATCGCAATACTCCGACTGCCCGGCCCCAGG
CGCCGCAACTGCAGAAGTATCTGCAGGACATGGTGCGAGTGCTGGCGGTGGCCACCGAGATGACCGGCGATGTCCAGCGG
GCGGTTTTCCTGTTGCGCAACGAGCCGCTGCGAGCCTTCGGCTACAAGACCGCTGACACTCTGATTCAGGAAGGTCGCGC
CGATGCGGTCATCGCCTACCTGGAATCCTTCGCCGGCGGTGCGGCCGGATGA

Structures

Toxin

• AlphaFold DB: A0A127MRU9

Antitoxin

• AlphaFold DB: A0A127MSF5