Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 853932..855594 Replicon chromosome
Accession NZ_CP014158
Organism Pseudomonas citronellolis strain P3B5

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag PcP3B5_RS03945 Protein ID WP_145923848.1
Coordinates 854758..855594 (-) Length 279 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A127MMF0
Locus tag PcP3B5_RS03940 Protein ID WP_043315318.1
Coordinates 853932..854753 (-) Length 274 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PcP3B5_RS03920 849151..850638 - 1488 WP_061560598.1 aldehyde dehydrogenase -
PcP3B5_RS03925 850649..851452 - 804 WP_058071795.1 aspartate dehydrogenase -
PcP3B5_RS03930 851463..853145 - 1683 WP_061560599.1 thiamine pyrophosphate-binding protein -
PcP3B5_RS03935 853138..853935 - 798 WP_061560600.1 SDR family oxidoreductase -
PcP3B5_RS03940 853932..854753 - 822 WP_043315318.1 IclR family transcriptional regulator Antitoxin
PcP3B5_RS03945 854758..855594 - 837 WP_145923848.1 alpha/beta fold hydrolase Toxin
PcP3B5_RS03950 855614..856147 - 534 WP_043315315.1 cupin domain-containing protein -
PcP3B5_RS03955 856159..856920 - 762 WP_061560602.1 SDR family oxidoreductase -
PcP3B5_RS03960 856931..857704 - 774 WP_061560603.1 ABC transporter permease -
PcP3B5_RS03965 857721..858719 - 999 WP_061560604.1 ABC transporter substrate-binding protein -
PcP3B5_RS03970 858740..859582 - 843 WP_145923969.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(40-268)

Antitoxin

Transcription regulator IclR, C-terminal

(133-254)


Sequences

Toxin        


Download         Length: 279 a.a.        Molecular weight: 29247.73 Da        Isoelectric Point: 7.0045

>T60300 WP_145923848.1 NZ_CP014158:c855594-854758 [Pseudomonas citronellolis]
MSTAAAWQADLECDFPQRLARHGEVVSAWREAGAADAPALVLLHGIGSGAASWLPLAQCLKARARLIAWDAPGYGESTPL
AEAAPRAEAYMQRLRELLDALDVQRCVLLGHSLGALTALALANAEPRRVARLLLLSPARGYGARPAEGEAVRSRRLAALA
SEGIAGLAERRAPAMLGASPGAEAVAWVRWNMARLKPHGYRQAVELLCGDDLLRLGRPPVPVEVLCGSEDGITPPAACRE
VAAALAAPFQLVPGAGHASPIECPEALAGHLVRFLDKD

Download         Length: 837 bp

>T60300 NZ_CP014158:c855594-854758 [Pseudomonas citronellolis]
ATGAGCACGGCGGCCGCCTGGCAGGCCGACCTGGAATGCGACTTCCCGCAGCGCCTGGCGCGCCACGGCGAGGTCGTCAG
CGCCTGGCGCGAAGCCGGCGCGGCCGATGCCCCGGCGCTGGTGCTGCTGCACGGCATCGGCTCAGGCGCGGCCTCCTGGC
TGCCGCTGGCGCAGTGCCTGAAGGCGCGCGCGCGGCTCATCGCCTGGGACGCCCCCGGCTACGGCGAATCCACGCCGCTG
GCCGAGGCCGCGCCGCGGGCGGAAGCCTACATGCAGCGCCTGCGCGAGCTGCTGGACGCGCTGGACGTGCAGCGCTGCGT
GCTGCTCGGCCATTCCCTGGGCGCGCTGACCGCCCTCGCCCTGGCCAACGCCGAGCCGCGGCGCGTTGCCCGCCTGCTGC
TGCTGAGCCCGGCGCGCGGCTACGGCGCGCGCCCGGCCGAAGGCGAAGCGGTACGCAGCCGGCGCCTGGCCGCTCTGGCC
AGCGAGGGCATCGCCGGCCTCGCCGAACGCCGCGCCCCGGCCATGCTCGGCGCCAGCCCCGGCGCCGAGGCGGTGGCCTG
GGTGCGCTGGAACATGGCGCGGCTCAAGCCCCACGGCTACCGCCAGGCGGTGGAGCTGCTGTGCGGCGACGACCTGCTGC
GCCTGGGCCGCCCGCCGGTGCCCGTCGAGGTGCTGTGCGGCAGCGAGGACGGCATCACCCCGCCGGCCGCCTGCCGCGAA
GTCGCCGCGGCGCTGGCGGCGCCCTTCCAGCTCGTCCCCGGCGCCGGCCACGCCAGCCCCATCGAATGCCCCGAAGCCCT
GGCCGGACATCTCGTCCGCTTCCTCGACAAGGACTGA

Antitoxin


Download         Length: 274 a.a.        Molecular weight: 30342.91 Da        Isoelectric Point: 6.7546

>AT60300 WP_043315318.1 NZ_CP014158:c854753-853932 [Pseudomonas citronellolis]
MSTDTLTENQERYMVPGLERGLTLLGEFTRHDRTLTAPELARRLQLPRTTIFRLLATLEALGFVTRSGNEYRLGMAVLRL
GFEYLASLELTELGQPILRRLCDAIGYSCNLVVRDGRNIVYVAKISPPSILTSAVNVGTRLPAHATVLGRILLEDLDLAA
LRELYPEKQLERFSEGTPRNTEELFDLVQNDRLRGYALSEGFFEASISTVAAPVRDHTGRVCAAMGVTIPATRIAEHLLE
PLVRQVRNSAEELSGLLGHMPNPNVLSLQRVHS

Download         Length: 822 bp

>AT60300 NZ_CP014158:c854753-853932 [Pseudomonas citronellolis]
ATGAGTACCGACACCCTCACCGAAAACCAGGAACGCTACATGGTTCCGGGGCTGGAACGCGGCCTGACGCTGCTGGGCGA
GTTCACCCGCCACGACCGCACCCTCACCGCCCCGGAACTGGCGCGCCGCCTGCAACTGCCGCGCACCACCATCTTCCGCC
TGCTGGCCACCCTCGAGGCCCTGGGCTTCGTCACCCGCAGCGGCAACGAATACCGCCTGGGCATGGCGGTGCTGCGCCTG
GGCTTCGAATACCTGGCCTCGCTGGAACTCACCGAGCTGGGCCAGCCGATCCTGCGCCGCCTGTGCGACGCCATCGGCTA
CTCCTGCAACCTGGTGGTGCGCGACGGGCGCAACATCGTCTACGTGGCGAAGATCTCGCCGCCGTCGATCCTCACCAGCG
CGGTCAACGTCGGCACCCGCCTGCCGGCCCACGCCACCGTGCTCGGGCGCATCCTCCTGGAAGACCTGGACCTCGCCGCG
CTGCGCGAGCTGTACCCGGAGAAGCAGCTGGAGCGCTTCTCCGAGGGCACCCCACGCAACACCGAGGAACTCTTCGACCT
GGTGCAGAACGACCGCCTGCGCGGCTATGCGCTGAGCGAAGGCTTCTTCGAGGCGAGCATCTCCACCGTCGCCGCGCCGG
TGCGCGACCACACCGGGCGTGTCTGCGCCGCCATGGGCGTGACCATCCCCGCCACGCGCATCGCCGAGCACCTGCTGGAA
CCGCTGGTGCGTCAGGTGCGCAACAGCGCCGAGGAACTCTCCGGCCTGCTCGGGCACATGCCCAACCCCAACGTCCTGTC
GCTGCAGAGGGTGCATTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A127MMF0

References