Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 124639..125144 Replicon chromosome
Accession NZ_CP014158
Organism Pseudomonas citronellolis strain P3B5

Toxin (Protein)


Gene name parE Uniprot ID W5IQ81
Locus tag PcP3B5_RS00570 Protein ID WP_009614629.1
Coordinates 124639..124920 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID W5IQE2
Locus tag PcP3B5_RS00575 Protein ID WP_009614631.1
Coordinates 124917..125144 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PcP3B5_RS00540 120002..121204 + 1203 WP_061560304.1 zinc metallochaperone GTPase ZigA -
PcP3B5_RS00545 121204..121821 + 618 WP_043270022.1 DUF1826 domain-containing protein -
PcP3B5_RS00550 121818..122273 - 456 WP_043270020.1 GNAT family N-acetyltransferase -
PcP3B5_RS00555 122332..123249 - 918 WP_043270018.1 LysR family transcriptional regulator -
PcP3B5_RS00560 123347..123628 + 282 WP_009614626.1 DUF2218 domain-containing protein -
PcP3B5_RS00565 123669..124379 - 711 WP_043270015.1 RcnB family protein -
PcP3B5_RS00570 124639..124920 - 282 WP_009614629.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PcP3B5_RS00575 124917..125144 - 228 WP_009614631.1 CopG family ribbon-helix-helix protein Antitoxin
PcP3B5_RS00580 125425..126381 + 957 WP_043270013.1 agmatinase -
PcP3B5_RS00585 126456..127382 + 927 WP_043270011.1 LysR family transcriptional regulator -
PcP3B5_RS00590 127379..128110 + 732 WP_043270009.1 phytanoyl-CoA dioxygenase family protein -
PcP3B5_RS00595 128122..128523 + 402 WP_009614637.1 GFA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10251.74 Da        Isoelectric Point: 6.4614

>T60297 WP_009614629.1 NZ_CP014158:c124920-124639 [Pseudomonas citronellolis]
MSLQWTHKAAADLDGLYDHYVVLIGPEKALKAIQDVVGQVKALADLSLSSVGRPSEVPGVRELPLERWPYQAAYRVKGRD
VQILRIDSVDNPG

Download         Length: 282 bp

>T60297 NZ_CP014158:c124920-124639 [Pseudomonas citronellolis]
ATGAGCCTGCAGTGGACGCACAAGGCGGCCGCCGACCTGGACGGCCTGTACGACCACTACGTGGTGCTGATCGGCCCGGA
GAAGGCGCTGAAGGCCATCCAGGACGTGGTCGGCCAGGTGAAGGCGCTGGCCGACCTCAGCCTGAGCAGCGTCGGCCGGC
CCAGCGAGGTGCCCGGCGTGCGCGAATTGCCGCTGGAACGCTGGCCCTACCAGGCCGCCTACCGGGTAAAAGGCCGCGAT
GTACAAATTTTGCGCATCGATTCTGTGGATAACCCGGGGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8357.42 Da        Isoelectric Point: 6.6405

>AT60297 WP_009614631.1 NZ_CP014158:c125144-124917 [Pseudomonas citronellolis]
MTTVISFRADDALAKALDQLARATHRDRPYHLRQALAQYLERQSWHVAAIDEGLADANAGHLLPHAEIEAKWGLA

Download         Length: 228 bp

>AT60297 NZ_CP014158:c125144-124917 [Pseudomonas citronellolis]
TTGACCACCGTAATCTCCTTCCGCGCCGATGACGCCCTGGCCAAGGCCCTGGACCAACTGGCCCGAGCCACCCACCGGGA
CCGCCCCTACCACCTGCGCCAGGCCCTGGCGCAGTACCTGGAGCGCCAGAGCTGGCACGTGGCGGCCATCGACGAGGGCC
TGGCCGACGCCAACGCCGGGCACCTGCTGCCGCACGCCGAGATAGAAGCCAAGTGGGGGCTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A5D1B8

Antitoxin

Source ID Structure
AlphaFold DB A0A1S1GJG7

References