Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2005916..2006573 Replicon chromosome
Accession NZ_CP014156
Organism Klebsiella quasipneumoniae strain HKUOPL4

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag AWV60_RS09625 Protein ID WP_004205323.1
Coordinates 2005916..2006326 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AWV60_RS09630 Protein ID WP_002916312.1
Coordinates 2006307..2006573 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWV60_RS09605 2001916..2003649 - 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -
AWV60_RS09610 2003655..2004368 - 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AWV60_RS09615 2004391..2005287 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
AWV60_RS09620 2005388..2005909 + 522 WP_004205324.1 flavodoxin FldB -
AWV60_RS09625 2005916..2006326 - 411 WP_004205323.1 protein YgfX Toxin
AWV60_RS09630 2006307..2006573 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AWV60_RS09635 2006819..2007802 + 984 WP_017899798.1 tRNA-modifying protein YgfZ -
AWV60_RS09640 2007953..2008612 - 660 WP_053809968.1 hemolysin III family protein -
AWV60_RS09645 2008775..2009086 - 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
AWV60_RS09650 2009136..2009864 + 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
AWV60_RS09655 2009983..2011416 + 1434 WP_049004121.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T60295 WP_004205323.1 NZ_CP014156:c2006326-2005916 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T60295 NZ_CP014156:c2006326-2005916 [Klebsiella quasipneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCTCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTGCGCTGGCAAAACGCC
GACTGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT60295 WP_002916312.1 NZ_CP014156:c2006573-2006307 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT60295 NZ_CP014156:c2006573-2006307 [Klebsiella quasipneumoniae]
ATGGACATTAACAATAAAGCTCGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TATTCAACTGGCTGATGAACCATGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References