Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 992571..993190 Replicon chromosome
Accession NZ_CP014155
Organism Klebsiella quasipneumoniae strain HKUOPJ4

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag AWV59_RS04690 Protein ID WP_002892050.1
Coordinates 992571..992789 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag AWV59_RS04695 Protein ID WP_002892066.1
Coordinates 992816..993190 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWV59_RS04660 988615..988878 + 264 WP_004204754.1 type B 50S ribosomal protein L31 -
AWV59_RS04665 988878..989018 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
AWV59_RS04670 989015..989713 - 699 WP_053810701.1 GNAT family N-acetyltransferase -
AWV59_RS04675 989814..991271 + 1458 WP_049117056.1 PLP-dependent aminotransferase family protein -
AWV59_RS04680 991240..991710 - 471 WP_049093338.1 YlaC family protein -
AWV59_RS24330 991753..991875 + 123 WP_032431198.1 hypothetical protein -
AWV59_RS04685 991847..992413 - 567 WP_004204750.1 maltose O-acetyltransferase -
AWV59_RS04690 992571..992789 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
AWV59_RS04695 992816..993190 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
AWV59_RS04700 993675..996821 - 3147 WP_017898892.1 multidrug efflux RND transporter permease subunit -
AWV59_RS04705 996844..998037 - 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T60275 WP_002892050.1 NZ_CP014155:c992789-992571 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T60275 NZ_CP014155:c992789-992571 [Klebsiella quasipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACTATGAATAAGCTGTACGATAAAATCCCGACGTCCGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT60275 WP_002892066.1 NZ_CP014155:c993190-992816 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT60275 NZ_CP014155:c993190-992816 [Klebsiella quasipneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAACTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACATCGGCTGTCAATCTCCAGTTAAATGAACTGATCGAGC
ACATTGCCACATTCGCCCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACATTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGGTT
ATTTCGTTGTTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTTTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References