Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 242968..243587 Replicon chromosome
Accession NZ_CP014154
Organism Klebsiella quasipneumoniae strain HKUOPA4

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag AWV58_RS01240 Protein ID WP_002892050.1
Coordinates 242968..243186 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag AWV58_RS01245 Protein ID WP_002892066.1
Coordinates 243213..243587 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWV58_RS01210 239012..239275 + 264 WP_004204754.1 type B 50S ribosomal protein L31 -
AWV58_RS01215 239275..239415 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
AWV58_RS01220 239412..240110 - 699 WP_053810701.1 GNAT family N-acetyltransferase -
AWV58_RS01225 240211..241668 + 1458 WP_049117056.1 PLP-dependent aminotransferase family protein -
AWV58_RS01230 241637..242107 - 471 WP_049093338.1 YlaC family protein -
AWV58_RS25370 242150..242272 + 123 WP_032431198.1 hypothetical protein -
AWV58_RS01235 242244..242810 - 567 WP_004204750.1 maltose O-acetyltransferase -
AWV58_RS01240 242968..243186 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
AWV58_RS01245 243213..243587 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
AWV58_RS01250 244072..247218 - 3147 WP_017898892.1 multidrug efflux RND transporter permease subunit -
AWV58_RS01255 247241..248434 - 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T60264 WP_002892050.1 NZ_CP014154:c243186-242968 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T60264 NZ_CP014154:c243186-242968 [Klebsiella quasipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACTATGAATAAGCTGTACGATAAAATCCCGACGTCCGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT60264 WP_002892066.1 NZ_CP014154:c243587-243213 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT60264 NZ_CP014154:c243587-243213 [Klebsiella quasipneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAACTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACATCGGCTGTCAATCTCCAGTTAAATGAACTGATCGAGC
ACATTGCCACATTCGCCCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACATTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGGTT
ATTTCGTTGTTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTTTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References