Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1386800..1387259 Replicon chromosome
Accession NZ_CP014144
Organism Streptococcus salivarius strain JF

Toxin (Protein)


Gene name relE Uniprot ID A0A448ACE6
Locus tag AWB63_RS06560 Protein ID WP_038676362.1
Coordinates 1387005..1387259 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F8LI53
Locus tag AWB63_RS06555 Protein ID WP_013990356.1
Coordinates 1386800..1387015 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWB63_RS06540 1382969..1384579 + 1611 WP_038676369.1 alpha-glucosidase -
AWB63_RS06545 1384691..1385692 + 1002 WP_038676367.1 UDP-glucose 4-epimerase GalE -
AWB63_RS06550 1385827..1386669 + 843 WP_038676364.1 aldo/keto reductase -
AWB63_RS06555 1386800..1387015 + 216 WP_013990356.1 hypothetical protein Antitoxin
AWB63_RS06560 1387005..1387259 + 255 WP_038676362.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AWB63_RS06565 1387404..1388090 + 687 WP_038676360.1 DUF1275 domain-containing protein -
AWB63_RS06570 1388181..1388813 + 633 WP_021143918.1 nitroreductase family protein -
AWB63_RS06575 1388977..1389660 + 684 WP_014632931.1 response regulator transcription factor -
AWB63_RS06580 1389660..1390535 + 876 WP_038676357.1 HAMP domain-containing histidine kinase -
AWB63_RS06585 1390682..1391254 + 573 WP_072903575.1 DUF4352 domain-containing protein -
AWB63_RS06590 1391306..1392061 - 756 WP_038676355.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-57)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9876.63 Da        Isoelectric Point: 11.1183

>T60262 WP_038676362.1 NZ_CP014144:1387005-1387259 [Streptococcus salivarius]
MTYKIVPTPKFAKSFKKLDPFVRKQIKSYLNRITDNPRAKGKALVANRTGQWRYRIGAYRVIVNIQDNELIILALEVGHR
RDIY

Download         Length: 255 bp

>T60262 NZ_CP014144:1387005-1387259 [Streptococcus salivarius]
ATGACCTATAAGATAGTACCAACCCCTAAATTTGCCAAAAGTTTTAAAAAGTTGGATCCTTTTGTCAGGAAACAAATTAA
GTCTTATCTCAATCGTATCACAGATAATCCAAGAGCTAAGGGTAAGGCATTGGTTGCCAATCGAACTGGACAATGGCGCT
ATCGTATAGGTGCCTATCGTGTTATTGTCAATATTCAGGACAATGAACTAATCATACTTGCTCTCGAAGTTGGTCATAGA
CGTGATATCTATTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8016.98 Da        Isoelectric Point: 3.8852

>AT60262 WP_013990356.1 NZ_CP014144:1386800-1387015 [Streptococcus salivarius]
MTTITLKVSEADKKFMQAIAKFEGVSLSELIRTKTLDAIEDEYDARVADLALAEYEDYLENGGEVLNWDDL

Download         Length: 216 bp

>AT60262 NZ_CP014144:1386800-1387015 [Streptococcus salivarius]
ATGACAACAATTACATTGAAGGTTTCAGAAGCAGATAAGAAGTTCATGCAGGCAATTGCGAAATTTGAAGGCGTATCCTT
GTCAGAATTAATTCGTACCAAGACTTTAGACGCCATTGAGGATGAATACGATGCTAGAGTAGCCGATTTGGCCTTAGCAG
AATATGAAGACTATCTTGAAAACGGTGGGGAGGTGCTAAATTGGGATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A448ACE6

Antitoxin

Source ID Structure
AlphaFold DB F8LI53

References