Detailed information of TA system TA060260

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 2685797..2686938
• Replicon: chromosome
• Accession: NZ_CP014143
• Organism: Microbulbifer aggregans strain CCB-MM1

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A1C9W9D7
• Locus tag: AUP74_RS11695
• Protein ID: WP_069947725.1
• Coordinates: 2686141..2686938 (+)
• Length: 266 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: AUP74_RS11690
• Protein ID: WP_083261124.1
• Coordinates: 2685797..2686144 (+)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AUP74_RS11670	2681418..2683799	+	2382	WP_069947722.1	hypothetical protein	-
AUP74_RS11685	2684600..2685580	-	981	WP_069947723.1	zinc-dependent alcohol dehydrogenase family protein	-
AUP74_RS11690	2685797..2686144	+	348	WP_083261124.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
AUP74_RS11695	2686141..2686938	+	798	WP_069947725.1	RES family NAD+ phosphorylase	Toxin
AUP74_RS11700	2686965..2687945	+	981	WP_158514568.1	pyridoxal-phosphate dependent enzyme	-
AUP74_RS11705	2688128..2689003	+	876	WP_069947726.1	NAD(+) kinase	-
AUP74_RS11710	2689093..2690262	+	1170	WP_069947727.1	nucleotide sugar dehydrogenase	-
AUP74_RS17235	2690255..2690437	+	183	WP_145924389.1	hypothetical protein	-
AUP74_RS11715	2690474..2691868	+	1395	WP_145924390.1	glycosyltransferase family 4 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-225)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (66-113)

Sequences

Toxin

Protein

• Length: 266 a.a.
• Molecular weight: 29504.55 Da
• Isoelectric Point: 8.3299

>T60260 WP_069947725.1 NZ_CP014143:2686141-2686938 [Microbulbifer aggregans]
VSESLPDLIVTTRRRLLGKLYRIVESQEEVATRGLVDSLQKQQVLESLLERSKPASLPGSEGLHYLLATPFRYPPLPWGS
RFGRVSENGIFYGSKSLTTVLAEAAFYRLRFYSDMAEPPPRPITTYHNIFSAKYRIHQGVALQDAGWRPHWQKLSDPVDY
RFTQQLGTKLRGLGIEGVESFSARAIQTGLISLPTKGDIESTEGINVALFEPASLLKRPPAQEADVTAETGKDGVTFLIK
SAERVETREFQGTSFVVEGRLPEPA

Nucleotide

• Length: 798 bp

>T60260 NZ_CP014143:2686141-2686938 [Microbulbifer aggregans]
GTGAGCGAATCCCTGCCTGATCTCATCGTTACCACAAGACGTCGCTTGCTGGGGAAGCTCTACCGTATTGTGGAGTCTCA
GGAAGAGGTCGCTACCCGGGGGCTGGTGGACAGTCTCCAGAAACAGCAGGTGCTTGAGAGTCTGCTGGAGCGCAGCAAAC
CGGCAAGCTTGCCCGGAAGTGAGGGCCTCCACTATCTGCTGGCCACGCCTTTCCGTTACCCCCCTTTGCCCTGGGGTTCC
CGTTTCGGGCGTGTTTCCGAGAACGGCATTTTCTACGGCAGCAAAAGCCTAACCACAGTGCTTGCGGAGGCCGCGTTTTA
CCGGTTGCGCTTCTATTCCGATATGGCTGAGCCGCCACCCCGTCCGATCACCACTTACCACAATATCTTCTCCGCCAAGT
ACCGCATCCACCAGGGTGTGGCGCTGCAGGATGCTGGCTGGCGGCCTCACTGGCAAAAGCTGAGTGATCCGGTGGATTAT
CGCTTCACCCAGCAATTGGGCACAAAATTGCGGGGACTGGGTATCGAAGGAGTAGAGTCATTTTCCGCCCGGGCGATCCA
AACAGGGCTCATCAGTCTGCCCACTAAAGGCGATATCGAGAGCACTGAGGGAATCAATGTGGCGCTGTTCGAGCCTGCCT
CCCTCCTCAAGCGTCCCCCCGCGCAGGAGGCTGACGTGACTGCTGAAACCGGCAAAGATGGAGTCACTTTCCTGATCAAG
AGCGCAGAGCGCGTGGAGACCAGGGAGTTCCAGGGCACCAGTTTTGTGGTCGAGGGTCGGCTCCCCGAGCCGGCTTAA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 12863.84 Da
• Isoelectric Point: 9.7709

>AT60260 WP_083261124.1 NZ_CP014143:2685797-2686144 [Microbulbifer aggregans]
IKSSPTEGTVLLEALLRTSEQLGLRKRELGDIIHLDDRTLRRKVELDPESAPGQLGLLLVRAYRSAFVLMGGEEGARHWF
QTENRALNGVPRELATRIDGLVRVVSYLDAMRGKV

Nucleotide

• Length: 348 bp

>AT60260 NZ_CP014143:2685797-2686144 [Microbulbifer aggregans]
ATCAAATCCAGCCCAACGGAAGGCACCGTCCTTCTGGAGGCGTTGCTACGCACCAGTGAGCAACTCGGACTGAGAAAGCG
GGAGCTCGGGGACATCATTCACCTGGATGATCGCACCCTACGCCGCAAGGTCGAGCTCGATCCGGAAAGTGCACCAGGTC
AGCTGGGGCTTTTGTTGGTGCGCGCCTATCGATCTGCCTTTGTGCTGATGGGTGGTGAGGAGGGCGCGCGCCACTGGTTC
CAGACGGAAAACCGGGCCTTGAACGGTGTACCCCGGGAACTGGCTACCCGAATCGACGGCCTGGTTCGTGTTGTCAGTTA
CCTAGACGCCATGCGGGGCAAGGTGTGA

Structures

Toxin

• AlphaFold DB: A0A1C9W9D7