Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF-ParD
Location 3321650..3322288 Replicon chromosome
Accession NZ_CP014140
Organism Aneurinibacillus sp. XH2

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag ACH33_RS16420 Protein ID WP_057899974.1
Coordinates 3321650..3322000 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ACH33_RS16425 Protein ID WP_057899975.1
Coordinates 3322004..3322288 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACH33_RS16395 3316718..3317197 - 480 WP_057899970.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
ACH33_RS16400 3317227..3318249 - 1023 WP_057899971.1 thiamine-phosphate kinase -
ACH33_RS16405 3318230..3318712 - 483 WP_057900438.1 SprT family protein -
ACH33_RS16410 3318812..3319156 + 345 WP_057899972.1 hypothetical protein -
ACH33_RS19530 3319247..3319366 + 120 WP_091260565.1 cortex morphogenetic protein CmpA -
ACH33_RS16415 3319396..3321558 - 2163 WP_057899973.1 RNA-binding transcriptional accessory protein -
ACH33_RS16420 3321650..3322000 - 351 WP_057899974.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
ACH33_RS16425 3322004..3322288 - 285 WP_057899975.1 ribbon-helix-helix protein, CopG family Antitoxin
ACH33_RS16430 3322551..3323735 - 1185 WP_057899976.1 alanine racemase -
ACH33_RS16435 3323739..3324176 - 438 WP_057899977.1 hypothetical protein -
ACH33_RS16440 3324530..3325042 + 513 WP_057899978.1 hypothetical protein -
ACH33_RS16445 3325215..3325682 - 468 WP_057899979.1 hypothetical protein -
ACH33_RS19740 3325798..3325959 - 162 WP_162265053.1 hypothetical protein -
ACH33_RS19535 3326317..3326487 + 171 WP_162265054.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-47)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12959.94 Da        Isoelectric Point: 4.8668

>T60257 WP_057899974.1 NZ_CP014140:c3322000-3321650 [Aneurinibacillus sp. XH2]
VIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKTYAFDRDSVILLEQI
RTIDKQRLTDKITHLDEEMMERVNEALQISLGLIDF

Download         Length: 351 bp

>T60257 NZ_CP014140:c3322000-3321650 [Aneurinibacillus sp. XH2]
GTGATCGTGAAGCGTGGCGACGTATATTTTGCGGATTTATCCCCTGTTGTCGGATCGGAGCAGGGCGGAGTCCGGCCTGT
GCTGGTTATACAGAATGATATAGGAAACCGCTTCAGTCCGACAGTAATCGTCGCAGCCATTACGGCCCAAATCCAAAAAG
CTAAGTTGCCTACCCATGTAGAAATTGATGCAAAGACATACGCATTTGACCGTGATTCTGTTATCCTGCTTGAGCAGATA
CGGACGATTGATAAACAGAGATTAACGGATAAGATCACACACCTTGATGAAGAGATGATGGAGCGAGTAAATGAAGCTCT
TCAGATTAGTTTGGGACTTATTGACTTTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10953.81 Da        Isoelectric Point: 8.5616

>AT60257 WP_057899975.1 NZ_CP014140:c3322288-3322004 [Aneurinibacillus sp. XH2]
MVLSKMDTKRIMISLPGHLLQEVDGLVEKEKSNRSEFIRQAMRLYLKERKKRHIREMMQRGYMEMANINLDIASEAFQAE
EEADLTLGRLVSGV

Download         Length: 285 bp

>AT60257 NZ_CP014140:c3322288-3322004 [Aneurinibacillus sp. XH2]
ATGGTCTTGTCTAAAATGGACACGAAGCGAATTATGATTAGCTTGCCGGGGCATCTATTGCAGGAAGTCGATGGATTGGT
GGAGAAAGAAAAATCTAATCGCAGCGAGTTTATCCGTCAGGCAATGAGATTATATTTGAAAGAGCGGAAGAAGCGGCATA
TTCGTGAAATGATGCAGCGTGGATATATGGAAATGGCCAATATTAATCTAGACATCGCGAGCGAGGCTTTTCAGGCTGAG
GAAGAAGCGGATTTGACATTGGGTCGTTTAGTGAGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References