Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1827238..1827724 Replicon chromosome
Accession NZ_CP014139
Organism Streptococcus pyogenes strain MEW123

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag AWM59_RS08850 Protein ID WP_014407961.1
Coordinates 1827238..1827507 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag AWM59_RS08855 Protein ID WP_014407962.1
Coordinates 1827497..1827724 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWM59_RS08835 1822733..1823806 + 1074 WP_011285298.1 DUF4097 family beta strand repeat protein -
AWM59_RS08840 1823923..1826196 - 2274 WP_021340697.1 YhgE/Pip domain-containing protein -
AWM59_RS08845 1826331..1826864 + 534 WP_010922785.1 TetR/AcrR family transcriptional regulator -
AWM59_RS08850 1827238..1827507 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AWM59_RS08855 1827497..1827724 - 228 WP_014407962.1 hypothetical protein Antitoxin
AWM59_RS08860 1827877..1828248 - 372 WP_011285302.1 DUF1492 domain-containing protein -
AWM59_RS08865 1828238..1828585 - 348 WP_011285303.1 DUF1492 domain-containing protein -
AWM59_RS08870 1828865..1829110 - 246 WP_011285304.1 hypothetical protein -
AWM59_RS08875 1829085..1829360 - 276 WP_014407964.1 hypothetical protein -
AWM59_RS08880 1829350..1829688 - 339 WP_030126557.1 replication protein -
AWM59_RS08885 1829730..1829995 - 266 Protein_1693 hypothetical protein -
AWM59_RS08890 1829992..1830780 - 789 WP_011285308.1 hypothetical protein -
AWM59_RS09880 1830871..1831029 - 159 WP_011285309.1 hypothetical protein -
AWM59_RS08895 1831043..1831288 - 246 WP_011285310.1 hypothetical protein -
AWM59_RS08900 1831284..1831610 - 327 Protein_1697 hypothetical protein -
AWM59_RS09885 1831612..1831785 - 174 WP_011285312.1 hypothetical protein -
AWM59_RS09555 1831791..1831964 - 174 WP_000694580.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T60256 WP_014407961.1 NZ_CP014139:c1827507-1827238 [Streptococcus pyogenes]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T60256 NZ_CP014139:c1827507-1827238 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT60256 WP_014407962.1 NZ_CP014139:c1827724-1827497 [Streptococcus pyogenes]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT60256 NZ_CP014139:c1827724-1827497 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References