Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3758122..3759766 Replicon chromosome
Accession NZ_CP014137
Organism Brenneria goodwinii strain FRB141

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag AWC36_RS16735 Protein ID WP_095834991.1
Coordinates 3758432..3759766 (+) Length 445 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag AWC36_RS16730 Protein ID WP_095834990.1
Coordinates 3758122..3758427 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWC36_RS16700 3753690..3754790 + 1101 WP_095834986.1 LPS export ABC transporter permease LptF -
AWC36_RS16705 3754790..3755860 + 1071 WP_048636440.1 LPS export ABC transporter permease LptG -
AWC36_RS16720 3756377..3757633 + 1257 WP_095834988.1 tyrosine-type recombinase/integrase -
AWC36_RS16725 3757652..3757813 + 162 WP_095834989.1 CopG family transcriptional regulator -
AWC36_RS16730 3758122..3758427 + 306 WP_095834990.1 helix-turn-helix transcriptional regulator Antitoxin
AWC36_RS16735 3758432..3759766 + 1335 WP_095834991.1 type II toxin-antitoxin system HipA family toxin Toxin
AWC36_RS16740 3759850..3760692 - 843 WP_095834992.1 IS3 family transposase -
AWC36_RS16745 3760866..3760991 - 126 WP_095834993.1 transposase -
AWC36_RS16750 3761184..3761543 + 360 WP_095834994.1 type II toxin-antitoxin system RelE/ParE family toxin -
AWC36_RS16755 3761527..3761850 + 324 WP_095834995.1 DNA-binding transcriptional regulator -
AWC36_RS16760 3761970..3763391 + 1422 WP_145957979.1 ParB N-terminal domain-containing protein -
AWC36_RS16765 3763457..3764326 + 870 WP_095834997.1 DNA adenine methylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 50880.02 Da        Isoelectric Point: 5.7122

>T60254 WP_095834991.1 NZ_CP014137:3758432-3759766 [Brenneria goodwinii]
MPRTQQRLAIWMNGIQVGFWEKTRGEDRLQYLPEWIADEQGRPLSLSLLFTPGNQLWRGNVVRDYFDNLLPDSEGIRRRL
ATRYHADSLEPFDLLAELGRDCVGAIQLLNGNEEPTDLFSVNYRPLCEAEIAAILRNTTAALLPGRQDDTDDLRLSIAGA
QEKTALLWHEGQWCLPEGSTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLILKEYGIPVAKTQIAQFEDQKVLVVERF
DRRWSSDRQWIIRLPQEDMCQAMGVSPLRKYQSDGGPGISDIMEILSHSEQAEQDKAQFFRAQIIFWLIAATDGHAKNFS
IAIEPQGRYHLTPLYDVLSAWPVIGPRNNQISWQKCKLAMAVRGSSNYYHLYRIQRRHWIKQGELTGLSRRQVESMMDDI
ISRTPEVIERVSALLPESFPPELAEYVFKGIRQQCGRLQELNLK

Download         Length: 1335 bp

>T60254 NZ_CP014137:3758432-3759766 [Brenneria goodwinii]
ATGCCTCGAACACAACAGCGTTTAGCAATATGGATGAATGGAATTCAAGTGGGATTCTGGGAAAAGACCCGAGGCGAAGA
TAGGTTGCAATATCTTCCCGAATGGATCGCTGATGAACAGGGAAGACCTTTATCGCTTTCTTTGCTTTTCACCCCCGGTA
ATCAGCTTTGGCGCGGCAATGTGGTACGCGACTATTTTGATAATTTATTGCCTGACAGCGAAGGTATACGCAGGCGTTTA
GCAACGCGTTACCATGCTGATAGCCTTGAGCCTTTTGATCTGTTGGCTGAGCTGGGAAGAGACTGTGTTGGCGCAATACA
GTTACTGAATGGTAATGAGGAGCCCACAGATCTATTTTCCGTAAATTATCGCCCACTTTGTGAAGCTGAGATCGCCGCTA
TATTGCGTAATACAACAGCGGCATTGTTGCCAGGTCGGCAGGATGATACTGACGATTTACGTTTATCGATTGCCGGTGCG
CAGGAAAAAACGGCTTTACTCTGGCATGAAGGACAATGGTGCTTGCCAGAAGGTAGTACCCCTACGACGCATATTTTCAA
GTTACCACTCGGGCTGGTGGGTAATATGCAAGCGGATATGAGTACGTCGGTTGAAAATGAATGGCTATGTTCTTTGATCC
TTAAGGAATATGGAATTCCTGTCGCAAAAACACAGATTGCGCAGTTTGAAGATCAGAAGGTATTGGTTGTTGAGCGTTTT
GACAGAAGATGGTCAAGTGATCGGCAATGGATCATTCGCTTGCCACAAGAGGATATGTGTCAGGCTATGGGGGTTTCCCC
GCTACGAAAATACCAGTCTGATGGTGGGCCGGGGATTTCCGATATTATGGAAATACTGAGTCATTCGGAGCAGGCTGAGC
AGGACAAAGCGCAGTTTTTCAGAGCGCAAATTATTTTCTGGCTGATAGCGGCTACTGATGGGCACGCCAAAAATTTCAGT
ATCGCTATTGAGCCACAAGGTCGTTATCACCTTACACCGCTTTATGATGTTTTATCGGCATGGCCGGTCATTGGTCCGCG
TAATAACCAGATTTCCTGGCAGAAGTGCAAGCTGGCAATGGCTGTTCGGGGTAGCAGTAATTATTACCATCTGTACAGAA
TTCAACGGCGACATTGGATCAAGCAGGGTGAGTTAACCGGTCTGAGCAGACGACAGGTTGAATCCATGATGGATGATATT
ATCTCCAGAACACCTGAAGTTATTGAACGTGTATCTGCGTTGCTGCCTGAGTCATTCCCACCAGAGCTTGCGGAATATGT
TTTTAAGGGTATACGGCAACAGTGTGGTCGGTTACAAGAATTGAACCTTAAATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11385.17 Da        Isoelectric Point: 10.3104

>AT60254 WP_095834990.1 NZ_CP014137:3758122-3758427 [Brenneria goodwinii]
MNTVYPLKTLNQLRPLLIGFRKAKGLTQKDVSERLGVTQQTYARLEANPGSASIERLFKVLTVLGVEVVLSSEPRVHFSM
SSSTMEEPEKPIDSPARREKW

Download         Length: 306 bp

>AT60254 NZ_CP014137:3758122-3758427 [Brenneria goodwinii]
ATGAATACAGTCTATCCGTTGAAAACCTTGAATCAGTTGCGCCCATTGCTGATTGGCTTTCGCAAAGCTAAGGGACTGAC
GCAAAAAGACGTGTCTGAAAGGTTAGGTGTAACACAGCAAACCTATGCCCGTTTGGAAGCAAACCCCGGAAGTGCCAGTA
TTGAGCGCTTGTTTAAAGTGCTCACCGTTCTGGGGGTTGAGGTGGTGCTGTCTTCTGAACCAAGAGTACATTTTTCTATG
TCATCCTCAACAATGGAAGAGCCAGAAAAGCCAATAGACTCACCCGCCAGACGGGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References