Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 4692887..4693477 Replicon chromosome
Accession NZ_CP014136
Organism Gibbsiella quercinecans strain FRB97

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag AWC35_RS21495 Protein ID WP_095848183.1
Coordinates 4692887..4693219 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag AWC35_RS21500 Protein ID WP_095848184.1
Coordinates 4693220..4693477 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWC35_RS21475 4688499..4689500 - 1002 WP_095848181.1 DUF1611 domain-containing protein -
AWC35_RS21480 4690218..4691165 - 948 WP_095848182.1 LysR family transcriptional regulator -
AWC35_RS21485 4691326..4692480 + 1155 WP_095849137.1 MFS transporter -
AWC35_RS21495 4692887..4693219 - 333 WP_095848183.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AWC35_RS21500 4693220..4693477 - 258 WP_095848184.1 antitoxin Antitoxin
AWC35_RS21510 4693825..4694031 - 207 WP_095848185.1 helix-turn-helix domain-containing protein -
AWC35_RS21515 4694028..4694495 - 468 WP_095848186.1 hypothetical protein -
AWC35_RS21520 4694944..4695272 + 329 Protein_4149 hypothetical protein -
AWC35_RS21525 4695557..4697767 - 2211 WP_095848187.1 ferric-rhodotorulic acid/ferric-coprogen receptor FhuE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4689920..4708329 18409


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11754.60 Da        Isoelectric Point: 10.5834

>T60237 WP_095848183.1 NZ_CP014136:c4693219-4692887 [Gibbsiella quercinecans]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARSGKRLERIPDAVVNEVLARLEAILS

Download         Length: 333 bp

>T60237 NZ_CP014136:c4693219-4692887 [Gibbsiella quercinecans]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCCGGCCACGAGCAAAGTGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCCGTTGTTGTTCCCGTCACCAGCGGCGGAAACTTTGCCCGCA
CAGCCGGTTTTACCGTCTCACTGGACGGCGCGGGAACAAAAACAACGGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATGGGAGCCCGGAGCGGTAAGCGGCTGGAGCGTATACCCGATGCTGTCGTGAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9414.86 Da        Isoelectric Point: 4.2340

>AT60237 WP_095848184.1 NZ_CP014136:c4693477-4693220 [Gibbsiella quercinecans]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDQEWIDAPAV
GKEIL

Download         Length: 258 bp

>AT60237 NZ_CP014136:c4693477-4693220 [Gibbsiella quercinecans]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTGGGTATGACCATTGATAATGGCTGTCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAGTTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGTGAAGAGGATCAGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References