Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3440846..3441624 Replicon chromosome
Accession NZ_CP014136
Organism Gibbsiella quercinecans strain FRB97

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag AWC35_RS15995 Protein ID WP_095847225.1
Coordinates 3440846..3441334 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag AWC35_RS16000 Protein ID WP_095847226.1
Coordinates 3441331..3441624 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWC35_RS15980 3436353..3438494 + 2142 WP_095849057.1 TonB-dependent receptor -
AWC35_RS15985 3438504..3439340 + 837 WP_095847223.1 ABC transporter substrate-binding protein -
AWC35_RS15990 3439498..3440553 + 1056 WP_095847224.1 IS110 family transposase -
AWC35_RS15995 3440846..3441334 - 489 WP_095847225.1 GNAT family N-acetyltransferase Toxin
AWC35_RS16000 3441331..3441624 - 294 WP_095847226.1 DUF1778 domain-containing protein Antitoxin
AWC35_RS16005 3441888..3442793 - 906 WP_095849058.1 DMT family transporter -
AWC35_RS16010 3442778..3443656 - 879 WP_131928996.1 hypothetical protein -
AWC35_RS16015 3443653..3444051 - 399 WP_095847228.1 NUDIX domain-containing protein -
AWC35_RS16020 3444065..3444769 - 705 WP_183096693.1 hypothetical protein -
AWC35_RS16025 3444944..3445822 + 879 WP_095847230.1 LysR family transcriptional regulator -
AWC35_RS16030 3445855..3446490 - 636 WP_095847231.1 glutaredoxin 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3439498..3440553 1055


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17520.47 Da        Isoelectric Point: 7.7294

>T60234 WP_095847225.1 NZ_CP014136:c3441334-3440846 [Gibbsiella quercinecans]
MISPPEPLHAEHVLGPFCCGVDSMDNWLKQRAMKNQLTGASRTFVCCDGAKVLAYYSLASSAVVANAAPGRFRRNMPDPI
PVVILGRLAVDKSLHSQGIGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYQRVGFEPSPMDPMMLMITLGDLLA
SA

Download         Length: 489 bp

>T60234 NZ_CP014136:c3441334-3440846 [Gibbsiella quercinecans]
ATGATCTCCCCCCCGGAGCCGCTTCATGCTGAACATGTACTCGGCCCGTTTTGTTGCGGCGTGGATTCTATGGATAACTG
GCTGAAACAACGGGCGATGAAAAATCAGTTAACCGGTGCATCAAGAACATTTGTCTGCTGCGACGGTGCGAAAGTGCTGG
CGTATTACTCACTGGCATCCAGTGCGGTAGTGGCAAACGCGGCGCCTGGCCGCTTTCGCCGTAATATGCCTGATCCAATC
CCGGTGGTCATACTGGGGCGTCTGGCGGTAGACAAATCATTGCACAGTCAGGGTATCGGACGGGCACTGGTGCGAGATGC
CGGCCTACGGGTGATTCAAGTGGCGGAAACTATCGGTATCCGGGGGATGCTGGTTCATGCCTTATCTGATGAAGCGCGGG
ATTTTTACCAACGGGTGGGGTTTGAGCCCTCGCCGATGGATCCGATGATGCTGATGATAACGCTGGGGGATTTGCTTGCC
AGTGCTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10908.52 Da        Isoelectric Point: 10.1412

>AT60234 WP_095847226.1 NZ_CP014136:c3441624-3441331 [Gibbsiella quercinecans]
MPVTNHVSGKRETLNLRIKPAERDLIDRAAKAKGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLTRLDQAPAPN
AALRKTMQTPAPWDQKK

Download         Length: 294 bp

>AT60234 NZ_CP014136:c3441624-3441331 [Gibbsiella quercinecans]
ATGCCCGTTACGAATCACGTTTCCGGCAAGCGCGAAACATTGAATTTACGCATTAAACCCGCCGAACGCGATCTTATCGA
TCGAGCGGCGAAAGCCAAAGGCAAAAACCGAACCGATTTTGTTCTGGAAGCGGCTCGCGCCGCCGCAGAAGAAGCATTAA
TCGAACAACGCATTATTATGGCAGATCCTGAAGCCTATCAGGAATTTCTTACCCGTCTGGATCAGGCTCCTGCGCCAAAC
GCCGCGCTGCGAAAAACCATGCAAACGCCTGCGCCTTGGGATCAGAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References