Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1394442..1395063 Replicon chromosome
Accession NZ_CP014136
Organism Gibbsiella quercinecans strain FRB97

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag AWC35_RS06520 Protein ID WP_095845586.1
Coordinates 1394860..1395063 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag AWC35_RS06515 Protein ID WP_095845585.1
Coordinates 1394442..1394810 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWC35_RS06480 1390533..1390787 + 255 WP_095845579.1 type B 50S ribosomal protein L31 -
AWC35_RS06485 1390799..1390939 + 141 WP_073529259.1 type B 50S ribosomal protein L36 -
AWC35_RS06490 1391040..1391918 - 879 WP_095845580.1 metal ABC transporter substrate-binding protein -
AWC35_RS06495 1391946..1392803 - 858 WP_095845581.1 metal ABC transporter permease -
AWC35_RS06500 1392800..1393510 - 711 WP_095845582.1 ABC transporter ATP-binding protein -
AWC35_RS06510 1393929..1394282 + 354 WP_095845584.1 hypothetical protein -
AWC35_RS06515 1394442..1394810 + 369 WP_095845585.1 Hha toxicity modulator TomB Antitoxin
AWC35_RS06520 1394860..1395063 + 204 WP_095845586.1 hemolysin expression modulator Hha Toxin
AWC35_RS06530 1395889..1396203 + 315 WP_095845587.1 MGMT family protein -
AWC35_RS06535 1396247..1396741 - 495 WP_095845588.1 YbaY family lipoprotein -
AWC35_RS06540 1396969..1397835 + 867 WP_095845589.1 acyl-CoA thioesterase II -
AWC35_RS06545 1397920..1399206 - 1287 WP_121525299.1 ammonium transporter AmtB -
AWC35_RS06550 1399245..1399583 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8116.42 Da        Isoelectric Point: 6.9756

>T60231 WP_095845586.1 NZ_CP014136:1394860-1395063 [Gibbsiella quercinecans]
MTKIDYLMRLRKCTNLDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTAVWKYVR

Download         Length: 204 bp

>T60231 NZ_CP014136:1394860-1395063 [Gibbsiella quercinecans]
ATGACAAAGATCGACTATTTGATGCGGTTACGTAAATGCACCAACCTTGACACGCTGGAGCGTGTTATTGAAAAAAATAA
ATACGAGCTTTCCGATGACGAGCTTGAGCTGTTTTATTCCGCAGCCGATCACCGCCTGGCGGAGCTCACCATGAATAAGC
TGTATGATAAAATCCCTACCGCAGTCTGGAAATACGTACGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14075.70 Da        Isoelectric Point: 4.4085

>AT60231 WP_095845585.1 NZ_CP014136:1394442-1394810 [Gibbsiella quercinecans]
MDEYSPKRHDIAQLKFLCENLYDEGLATIGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESELSDLVEEYL
DDTYTLFSNYGINDSDLGRWQKTKARLFRMFSGEGTCTAMKS

Download         Length: 369 bp

>AT60231 NZ_CP014136:1394442-1394810 [Gibbsiella quercinecans]
ATGGATGAGTATTCGCCTAAGCGGCACGATATTGCTCAACTGAAGTTCTTGTGTGAGAATCTTTATGATGAGGGCCTCGC
GACAATAGGCGACAGCCATCATGGTTGGGTGAACGATCCAACGTCTTCCGTCAATCTCCAGCTTAACGAGTTGATCGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAAAGCGAACTCTCGGATCTGGTCGAAGAGTATCTC
GACGACACTTATACCCTTTTTAGTAATTACGGTATTAATGATTCAGACTTGGGCCGTTGGCAAAAAACCAAGGCACGATT
ATTCAGAATGTTCTCAGGAGAGGGCACCTGTACGGCAATGAAATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References