Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 83402..83949 | Replicon | chromosome |
| Accession | NZ_CP014134 | ||
| Organism | Vibrio diabolicus strain FDAARGOS_99 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | AL468_RS09335 | Protein ID | WP_048625643.1 |
| Coordinates | 83647..83949 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U3A269 |
| Locus tag | AL468_RS09330 | Protein ID | WP_005448240.1 |
| Coordinates | 83402..83659 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AL468_RS09295 | 78888..79874 | + | 987 | WP_210405570.1 | DUF4263 domain-containing protein | - |
| AL468_RS09300 | 79997..80494 | + | 498 | WP_104973978.1 | DNA topology modulation protein | - |
| AL468_RS09310 | 80623..81447 | + | 825 | WP_104973979.1 | hypothetical protein | - |
| AL468_RS09315 | 81552..81926 | + | 375 | WP_146106799.1 | hypothetical protein | - |
| AL468_RS09320 | 81969..83146 | + | 1178 | WP_104873539.1 | IS3 family transposase | - |
| AL468_RS09325 | 83228..83320 | + | 93 | WP_006074995.1 | DUF3265 domain-containing protein | - |
| AL468_RS09330 | 83402..83659 | + | 258 | WP_005448240.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| AL468_RS09335 | 83647..83949 | + | 303 | WP_048625643.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AL468_RS09340 | 83985..84077 | + | 93 | WP_079856868.1 | DUF3265 domain-containing protein | - |
| AL468_RS09345 | 84103..84306 | + | 204 | Protein_141 | hypothetical protein | - |
| AL468_RS09350 | 84579..84671 | + | 93 | WP_079752454.1 | DUF3265 domain-containing protein | - |
| AL468_RS09360 | 85031..85207 | + | 177 | WP_104973981.1 | DUF3265 domain-containing protein | - |
| AL468_RS09365 | 85185..85617 | + | 433 | Protein_144 | nuclear transport factor 2 family protein | - |
| AL468_RS09370 | 85635..85724 | + | 90 | WP_193387724.1 | DUF3265 domain-containing protein | - |
| AL468_RS09375 | 85753..86274 | + | 522 | WP_069549561.1 | hypothetical protein | - |
| AL468_RS24865 | 86287..86388 | + | 102 | WP_079764591.1 | DUF3265 domain-containing protein | - |
| AL468_RS09380 | 86426..86878 | + | 453 | WP_043048411.1 | PH domain-containing protein | - |
| AL468_RS09390 | 87030..87313 | + | 284 | Protein_149 | nucleotide pyrophosphohydrolase | - |
| AL468_RS09395 | 87321..87431 | + | 111 | WP_074190920.1 | DUF3265 domain-containing protein | - |
| AL468_RS09400 | 87459..88796 | + | 1338 | WP_104973985.1 | hypothetical protein | - |
| AL468_RS09405 | 88811..88903 | + | 93 | WP_086591474.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 27819..131637 | 103818 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11699.66 Da Isoelectric Point: 5.1765
>T60229 WP_048625643.1 NZ_CP014134:83647-83949 [Vibrio diabolicus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQMIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQMIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
Download Length: 303 bp
>T60229 NZ_CP014134:83647-83949 [Vibrio diabolicus]
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCTCTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAATGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGCCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAA
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCTCTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAATGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGCCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9606.10 Da Isoelectric Point: 6.7269
>AT60229 WP_005448240.1 NZ_CP014134:83402-83659 [Vibrio diabolicus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
Download Length: 258 bp
>AT60229 NZ_CP014134:83402-83659 [Vibrio diabolicus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCGTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGACGGTAAAGTGGTAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCGTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGACGGTAAAGTGGTAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|