Detailed information of TA system TA060229

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 83402..83949
• Replicon: chromosome
• Accession: NZ_CP014134
• Organism: Vibrio diabolicus strain FDAARGOS_99

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AL468_RS09335
• Protein ID: WP_048625643.1
• Coordinates: 83647..83949 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3A269
• Locus tag: AL468_RS09330
• Protein ID: WP_005448240.1
• Coordinates: 83402..83659 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL468_RS09295	78888..79874	+	987	WP_210405570.1	DUF4263 domain-containing protein	-
AL468_RS09300	79997..80494	+	498	WP_104973978.1	DNA topology modulation protein	-
AL468_RS09310	80623..81447	+	825	WP_104973979.1	hypothetical protein	-
AL468_RS09315	81552..81926	+	375	WP_146106799.1	hypothetical protein	-
AL468_RS09320	81969..83146	+	1178	WP_104873539.1	IS3 family transposase	-
AL468_RS09325	83228..83320	+	93	WP_006074995.1	DUF3265 domain-containing protein	-
AL468_RS09330	83402..83659	+	258	WP_005448240.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AL468_RS09335	83647..83949	+	303	WP_048625643.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AL468_RS09340	83985..84077	+	93	WP_079856868.1	DUF3265 domain-containing protein	-
AL468_RS09345	84103..84306	+	204	Protein_141	hypothetical protein	-
AL468_RS09350	84579..84671	+	93	WP_079752454.1	DUF3265 domain-containing protein	-
AL468_RS09360	85031..85207	+	177	WP_104973981.1	DUF3265 domain-containing protein	-
AL468_RS09365	85185..85617	+	433	Protein_144	nuclear transport factor 2 family protein	-
AL468_RS09370	85635..85724	+	90	WP_193387724.1	DUF3265 domain-containing protein	-
AL468_RS09375	85753..86274	+	522	WP_069549561.1	hypothetical protein	-
AL468_RS24865	86287..86388	+	102	WP_079764591.1	DUF3265 domain-containing protein	-
AL468_RS09380	86426..86878	+	453	WP_043048411.1	PH domain-containing protein	-
AL468_RS09390	87030..87313	+	284	Protein_149	nucleotide pyrophosphohydrolase	-
AL468_RS09395	87321..87431	+	111	WP_074190920.1	DUF3265 domain-containing protein	-
AL468_RS09400	87459..88796	+	1338	WP_104973985.1	hypothetical protein	-
AL468_RS09405	88811..88903	+	93	WP_086591474.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	27819..131637	103818

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11699.66 Da
• Isoelectric Point: 5.1765

>T60229 WP_048625643.1 NZ_CP014134:83647-83949 [Vibrio diabolicus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQMIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Nucleotide

• Length: 303 bp

>T60229 NZ_CP014134:83647-83949 [Vibrio diabolicus]
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCTCTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAATGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGCCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9606.10 Da
• Isoelectric Point: 6.7269

>AT60229 WP_005448240.1 NZ_CP014134:83402-83659 [Vibrio diabolicus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT60229 NZ_CP014134:83402-83659 [Vibrio diabolicus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCGTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGACGGTAAAGTGGTAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A432DGX8