Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 63355..63902 Replicon chromosome
Accession NZ_CP014134
Organism Vibrio diabolicus strain FDAARGOS_99

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR19
Locus tag AL468_RS09135 Protein ID WP_025548916.1
Coordinates 63600..63902 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag AL468_RS09130 Protein ID WP_005448240.1
Coordinates 63355..63612 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL468_RS09070 58796..59563 + 768 WP_168187794.1 hypothetical protein -
AL468_RS25040 59590..59682 + 93 WP_210405568.1 DUF3265 domain-containing protein -
AL468_RS09080 59719..60441 + 723 WP_104973955.1 hypothetical protein -
AL468_RS09085 60456..60548 + 93 WP_210405569.1 DUF3265 domain-containing protein -
AL468_RS09090 60576..60956 + 381 WP_168187793.1 nuclear transport factor 2 family protein -
AL468_RS09095 60984..61076 + 93 Protein_94 DUF3265 domain-containing protein -
AL468_RS09100 61114..61476 + 363 WP_104973957.1 hypothetical protein -
AL468_RS09105 61478..61900 + 423 WP_146106798.1 hypothetical protein -
AL468_RS09110 62070..62540 + 471 WP_104973959.1 GNAT family N-acetyltransferase -
AL468_RS09115 62570..62662 + 93 WP_004749136.1 DUF3265 domain-containing protein -
AL468_RS09125 63142..63273 + 132 WP_080992234.1 DUF3265 domain-containing protein -
AL468_RS09130 63355..63612 + 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AL468_RS09135 63600..63902 + 303 WP_025548916.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL468_RS09140 63938..64030 + 93 WP_079764222.1 DUF3265 domain-containing protein -
AL468_RS09145 64053..64631 + 579 WP_048625632.1 ankyrin repeat domain-containing protein -
AL468_RS09150 64613..64738 + 126 WP_084742290.1 DUF3265 domain-containing protein -
AL468_RS09155 64767..65666 + 900 WP_104973960.1 HNH endonuclease -
AL468_RS09160 65681..65773 + 93 WP_012841671.1 DUF3265 domain-containing protein -
AL468_RS25045 66233..66322 + 90 WP_210405576.1 DUF3265 domain-containing protein -
AL468_RS09170 66354..67616 + 1263 WP_104973961.1 hypothetical protein -
AL468_RS09175 67631..67723 + 93 WP_006074995.1 DUF3265 domain-containing protein -
AL468_RS09180 67772..68407 + 636 WP_104973962.1 LysE family transporter -
AL468_RS09185 68422..68514 + 93 WP_072612521.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 27819..131637 103818


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11669.57 Da        Isoelectric Point: 5.1765

>T60228 WP_025548916.1 NZ_CP014134:63600-63902 [Vibrio diabolicus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T60228 NZ_CP014134:63600-63902 [Vibrio diabolicus]
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCTGACCTAAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTACAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAGCAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT60228 WP_005448240.1 NZ_CP014134:63355-63612 [Vibrio diabolicus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT60228 NZ_CP014134:63355-63612 [Vibrio diabolicus]
ATGAAAGTAGAACTAGTTACATCACTTAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCTTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGAATTGCACGAGGTGAGCGTGCACTAGCTGACGGTAAAGTGGTAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR19

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References