Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2062396..2062905 Replicon chromosome
Accession NZ_CP014132
Organism Staphylococcus epidermidis strain FDAARGOS_161

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag AL521_RS10120 Protein ID WP_001829980.1
Coordinates 2062396..2062605 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag AL521_RS10125 Protein ID WP_001829893.1
Coordinates 2062612..2062905 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL521_RS10100 2057974..2059329 - 1356 WP_104992885.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
AL521_RS10105 2059341..2060414 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
AL521_RS10110 2060805..2062016 + 1212 WP_001829910.1 rod shape-determining protein RodA -
AL521_RS10115 2062116..2062253 - 138 WP_001829949.1 hypothetical protein -
AL521_RS10120 2062396..2062605 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
AL521_RS10125 2062612..2062905 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
AL521_RS10130 2063079..2064563 + 1485 WP_002457116.1 cardiolipin synthase -
AL521_RS10135 2064745..2065398 + 654 WP_001829983.1 HD domain-containing protein -
AL521_RS10140 2065504..2066376 - 873 WP_002458703.1 membrane protein insertase YidC -
AL521_RS10145 2066465..2067103 - 639 WP_002458704.1 thiamine phosphate synthase -
AL521_RS10150 2067109..2067897 - 789 WP_002486939.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T60227 WP_001829980.1 NZ_CP014132:c2062605-2062396 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T60227 NZ_CP014132:c2062605-2062396 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT60227 WP_001829893.1 NZ_CP014132:c2062905-2062612 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT60227 NZ_CP014132:c2062905-2062612 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References