Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2051193..2051722 Replicon chromosome
Accession NZ_CP014132
Organism Staphylococcus epidermidis strain FDAARGOS_161

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag AL521_RS10060 Protein ID WP_001829891.1
Coordinates 2051193..2051555 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag AL521_RS10065 Protein ID WP_001829931.1
Coordinates 2051552..2051722 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL521_RS10040 2048194..2048964 - 771 WP_002468952.1 RNA polymerase sigma factor SigB -
AL521_RS10045 2048939..2049418 - 480 WP_001829903.1 anti-sigma B factor RsbW -
AL521_RS10050 2049420..2049746 - 327 WP_001829952.1 anti-sigma factor antagonist -
AL521_RS10055 2049846..2050847 - 1002 WP_104992883.1 PP2C family protein-serine/threonine phosphatase -
AL521_RS10060 2051193..2051555 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AL521_RS10065 2051552..2051722 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
AL521_RS10070 2051809..2052957 - 1149 WP_104992884.1 alanine racemase -
AL521_RS10075 2053023..2053376 - 354 WP_001829915.1 holo-ACP synthase -
AL521_RS10080 2053424..2053933 - 510 WP_001829888.1 PH domain-containing protein -
AL521_RS10085 2053920..2055425 - 1506 WP_001829976.1 PH domain-containing protein -
AL521_RS10090 2055418..2055897 - 480 WP_001829909.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T60226 WP_001829891.1 NZ_CP014132:c2051555-2051193 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T60226 NZ_CP014132:c2051555-2051193 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT60226 WP_001829931.1 NZ_CP014132:c2051722-2051552 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT60226 NZ_CP014132:c2051722-2051552 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTTCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References