Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1175270..1175911 Replicon chromosome
Accession NZ_CP014129
Organism Pantoea vagans strain FDAARGOS_160

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AL522_RS09125 Protein ID WP_061061783.1
Coordinates 1175729..1175911 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AL522_RS09120 Protein ID WP_061061782.1
Coordinates 1175270..1175683 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL522_RS09055 1170606..1170830 + 225 WP_061061771.1 hypothetical protein -
AL522_RS09060 1170827..1171093 + 267 WP_192951270.1 DUF3850 domain-containing protein -
AL522_RS09065 1171074..1171430 + 357 WP_061061773.1 hypothetical protein -
AL522_RS09070 1171441..1171728 + 288 WP_061063676.1 hypothetical protein -
AL522_RS09075 1171725..1171922 + 198 WP_061061774.1 hypothetical protein -
AL522_RS09080 1171894..1172328 + 435 WP_061061775.1 recombination protein NinB -
AL522_RS09085 1172325..1172615 + 291 WP_061061776.1 hypothetical protein -
AL522_RS09090 1172608..1172808 + 201 WP_061061777.1 hypothetical protein -
AL522_RS09095 1172805..1173014 + 210 WP_105399982.1 hypothetical protein -
AL522_RS09100 1173104..1173289 + 186 WP_071888648.1 hypothetical protein -
AL522_RS09105 1173282..1173863 + 582 WP_061061779.1 recombination protein NinG -
AL522_RS09110 1173860..1174057 + 198 WP_061061780.1 Lar family restriction alleviation protein -
AL522_RS09115 1174169..1174990 + 822 WP_061061781.1 antitermination protein -
AL522_RS09120 1175270..1175683 - 414 WP_061061782.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AL522_RS09125 1175729..1175911 - 183 WP_061061783.1 type II toxin-antitoxin system HicA family toxin Toxin
AL522_RS09130 1176209..1176628 + 420 WP_061061784.1 hypothetical protein -
AL522_RS09135 1176625..1176861 + 237 WP_061061785.1 hypothetical protein -
AL522_RS09140 1176858..1177325 + 468 WP_061061786.1 glycoside hydrolase family protein -
AL522_RS09145 1177322..1177666 + 345 WP_061061787.1 hypothetical protein -
AL522_RS09150 1177663..1177959 + 297 WP_061061788.1 hypothetical protein -
AL522_RS09155 1178107..1178376 + 270 WP_061061789.1 hypothetical protein -
AL522_RS09160 1178654..1179181 + 528 WP_061061790.1 KilA-N domain-containing protein -
AL522_RS09165 1179273..1179707 - 435 WP_061061791.1 hypothetical protein -
AL522_RS09170 1179730..1180299 + 570 WP_061061792.1 terminase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1157525..1209600 52075


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-130)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6857.06 Da        Isoelectric Point: 10.7967

>T60220 WP_061061783.1 NZ_CP014129:c1175911-1175729 [Pantoea vagans]
MKSSELIKLLVKNGWQLDRVKGSHHQFSHPDFANIVTVPHPKKDLKTGTVHQIMKDAKLK

Download         Length: 183 bp

>T60220 NZ_CP014129:c1175911-1175729 [Pantoea vagans]
TTGAAAAGTTCGGAACTGATAAAGCTGTTAGTTAAAAACGGCTGGCAACTAGACAGAGTGAAAGGAAGTCATCACCAGTT
CAGCCACCCGGATTTCGCTAACATAGTAACGGTTCCGCACCCTAAGAAAGATTTGAAGACTGGTACAGTTCACCAAATCA
TGAAGGATGCGAAACTTAAATAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15194.18 Da        Isoelectric Point: 4.6799

>AT60220 WP_061061782.1 NZ_CP014129:c1175683-1175270 [Pantoea vagans]
MLYYGVVEIDHDKTASGYFPGITGCIFAGNDMREALQDAESALNAHFELMAEKGLSIPEANDIPDIDSGDYGESGLKVVM
ICVDIDITKYLGKSERINITMPHLLIEKIDRAVGQDSRYTSRSHFIAEAARKELSHR

Download         Length: 414 bp

>AT60220 NZ_CP014129:c1175683-1175270 [Pantoea vagans]
ATGTTGTATTACGGTGTCGTTGAGATTGACCACGACAAAACAGCCAGCGGTTATTTTCCCGGCATTACTGGCTGCATTTT
TGCAGGCAATGATATGCGGGAAGCACTGCAGGACGCAGAATCGGCGCTTAATGCTCACTTTGAGCTGATGGCTGAAAAGG
GTCTTTCCATTCCTGAAGCAAATGACATTCCTGATATTGATTCAGGTGATTATGGCGAAAGCGGATTGAAAGTAGTGATG
ATCTGCGTCGACATTGATATCACTAAGTATCTGGGAAAGTCTGAGCGCATTAACATCACCATGCCACACCTTCTGATTGA
GAAGATCGACAGGGCTGTAGGTCAGGACTCACGCTATACCAGCCGCAGCCATTTTATTGCAGAAGCAGCACGCAAAGAGC
TGTCTCACCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References