Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4623408..4623924 Replicon chromosome
Accession NZ_CP014123
Organism Klebsiella pneumoniae strain FDAARGOS_156

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag AL516_RS24145 Protein ID WP_009309309.1
Coordinates 4623408..4623692 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AL516_RS24150 Protein ID WP_002886901.1
Coordinates 4623682..4623924 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL516_RS24125 4618804..4619112 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
AL516_RS28440 4619197..4619370 + 174 WP_004222159.1 hypothetical protein -
AL516_RS24130 4619373..4620116 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AL516_RS24135 4620473..4622611 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
AL516_RS24140 4622940..4623404 + 465 WP_049000498.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AL516_RS24145 4623408..4623692 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL516_RS24150 4623682..4623924 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AL516_RS24155 4624002..4625912 - 1911 WP_104928198.1 BglG family transcription antiterminator -
AL516_RS24160 4625935..4627089 - 1155 WP_049000495.1 lactonase family protein -
AL516_RS24165 4627156..4627896 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T60214 WP_009309309.1 NZ_CP014123:c4623692-4623408 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T60214 NZ_CP014123:c4623692-4623408 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT60214 WP_002886901.1 NZ_CP014123:c4623924-4623682 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT60214 NZ_CP014123:c4623924-4623682 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References