60196

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 186736..187245 Replicon chromosome
Accession NZ_CP014119
Organism Staphylococcus epidermidis strain FDAARGOS_153

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag AL514_RS01330 Protein ID WP_001829980.1
Coordinates 186736..186945 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag AL514_RS01335 Protein ID WP_001829893.1
Coordinates 186952..187245 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL514_RS01310 182315..183670 - 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
AL514_RS01315 183682..184755 - 1074 WP_002468311.1 D-alanine--D-alanine ligase -
AL514_RS01320 185146..186357 + 1212 WP_002457115.1 rod shape-determining protein RodA -
AL514_RS01325 186456..186593 - 138 WP_001829949.1 hypothetical protein -
AL514_RS01330 186736..186945 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
AL514_RS01335 186952..187245 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
AL514_RS01340 187419..188903 + 1485 WP_002457116.1 cardiolipin synthase -
AL514_RS01345 189085..189738 + 654 WP_001829983.1 HD domain-containing protein -
AL514_RS01350 189844..190716 - 873 WP_002470121.1 membrane protein insertase YidC -
AL514_RS01355 190805..191443 - 639 WP_002505076.1 thiamine phosphate synthase -
AL514_RS01360 191449..192237 - 789 WP_002469583.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T60196 WP_001829980.1 NZ_CP014119:c186945-186736 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T60196 NZ_CP014119:c186945-186736 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT60196 WP_001829893.1 NZ_CP014119:c187245-186952 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT60196 NZ_CP014119:c187245-186952 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References