Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1517908..1518721 Replicon chromosome
Accession NZ_CP014113
Organism Staphylococcus saprophyticus strain FDAARGOS_168

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag AL528_RS07550 Protein ID WP_061050532.1
Coordinates 1517908..1518372 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag AL528_RS07555 Protein ID WP_061050533.1
Coordinates 1518386..1518721 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL528_RS07495 1514432..1514989 + 558 WP_011302822.1 alpha/beta hydrolase -
AL528_RS07540 1516236..1517276 - 1041 WP_081095017.1 site-specific integrase -
AL528_RS07545 1517328..1517819 - 492 WP_061050531.1 hypothetical protein -
AL528_RS07550 1517908..1518372 - 465 WP_061050532.1 ImmA/IrrE family metallo-endopeptidase Toxin
AL528_RS07555 1518386..1518721 - 336 WP_061050533.1 helix-turn-helix domain-containing protein Antitoxin
AL528_RS07560 1518885..1519115 + 231 WP_061050534.1 helix-turn-helix domain-containing protein -
AL528_RS07565 1519134..1520063 + 930 WP_061050535.1 DUF3102 domain-containing protein -
AL528_RS07570 1520056..1520613 + 558 WP_061050536.1 ORF6C domain-containing protein -
AL528_RS07575 1520739..1520957 - 219 WP_061050537.1 hypothetical protein -
AL528_RS07580 1521020..1521304 + 285 WP_081095018.1 DUF771 domain-containing protein -
AL528_RS13260 1521316..1521489 + 174 WP_192573647.1 hypothetical protein -
AL528_RS07585 1521551..1521835 + 285 WP_061050538.1 hypothetical protein -
AL528_RS07590 1521801..1522025 + 225 WP_061050539.1 DUF2483 family protein -
AL528_RS07595 1522018..1522635 + 618 WP_061050540.1 DUF1071 domain-containing protein -
AL528_RS07600 1522638..1523060 + 423 WP_061050541.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1514432..1561613 47181


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(27-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(6-61)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18295.92 Da        Isoelectric Point: 6.6569

>T60190 WP_061050532.1 NZ_CP014113:c1518372-1517908 [Staphylococcus saprophyticus]
MSRYENILIDNDNLDITETCHLPTKLSGVTFDNMIFIRSDMDHTHKLETLAEEIAHLHVTYGDIRDQSKLVNRKYELKAR
RYAYERLITLQGIIDAFHAGICNLHEMASYFEVSKSYVLDTIKHYKMKYGLDVYYKGYVIKFEPLQVFEHHKWD

Download         Length: 465 bp

>T60190 NZ_CP014113:c1518372-1517908 [Staphylococcus saprophyticus]
TTGAGTAGATACGAAAATATTTTAATCGACAATGATAACTTGGATATAACGGAAACTTGTCATCTACCCACTAAATTAAG
TGGTGTTACCTTTGATAATATGATATTCATACGCAGTGATATGGATCACACACACAAATTAGAAACACTAGCAGAAGAAA
TAGCCCACTTGCATGTTACTTACGGTGATATTCGTGACCAAAGTAAGTTAGTTAATAGAAAGTATGAGTTAAAAGCTAGA
CGTTACGCATATGAGCGTTTAATTACATTACAGGGTATTATTGATGCTTTTCATGCAGGCATATGTAATCTACATGAAAT
GGCAAGTTACTTTGAAGTATCTAAAAGTTATGTGCTAGATACAATTAAACATTACAAAATGAAATATGGATTAGATGTTT
ACTATAAGGGATATGTGATTAAGTTTGAGCCACTACAAGTGTTTGAACATCATAAATGGGATTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 13073.77 Da        Isoelectric Point: 4.8668

>AT60190 WP_061050533.1 NZ_CP014113:c1518721-1518386 [Staphylococcus saprophyticus]
MFSQNLKYLRNKHDMEQIDLAHKLGKKSASSISEWEKGKYTPKLKTLSEIATIFNVSIDDLMDEDLSIMKEENKQTNSFE
TIAAHLEDELTEEEWQEVIEYAEYIKSKRKK

Download         Length: 336 bp

>AT60190 NZ_CP014113:c1518721-1518386 [Staphylococcus saprophyticus]
ATGTTTAGCCAAAACTTAAAATACTTGAGAAATAAACACGATATGGAACAAATTGATCTTGCACATAAACTTGGTAAGAA
AAGCGCATCTAGTATTAGTGAATGGGAAAAGGGAAAATACACTCCTAAATTAAAAACCCTCTCAGAAATCGCAACAATAT
TTAATGTAAGTATTGATGATTTAATGGATGAAGATTTATCTATTATGAAAGAAGAAAATAAACAAACCAATTCTTTCGAA
ACTATTGCTGCACACTTAGAAGATGAATTAACAGAAGAAGAATGGCAAGAAGTCATTGAATACGCTGAATACATAAAATC
AAAGCGTAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References