Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1485668..1486474 Replicon chromosome
Accession NZ_CP014113
Organism Staphylococcus saprophyticus strain FDAARGOS_168

Toxin (Protein)


Gene name tsbT Uniprot ID Q49YQ0
Locus tag AL528_RS07360 Protein ID WP_011302805.1
Coordinates 1486289..1486474 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q49YQ1
Locus tag AL528_RS07355 Protein ID WP_011302804.1
Coordinates 1485668..1486267 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL528_RS07335 1481546..1483009 + 1464 WP_047502301.1 ABC transporter substrate-binding protein/permease -
AL528_RS07340 1483002..1483724 + 723 WP_002482873.1 amino acid ABC transporter ATP-binding protein -
AL528_RS07345 1483885..1485012 + 1128 WP_047502298.1 tRNA epoxyqueuosine(34) reductase QueG -
AL528_RS07350 1485017..1485487 + 471 WP_002482875.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
AL528_RS07355 1485668..1486267 + 600 WP_011302804.1 glucosamine-6-phosphate isomerase Antitoxin
AL528_RS07360 1486289..1486474 + 186 WP_011302805.1 hypothetical protein Toxin
AL528_RS07365 1486631..1487047 + 417 WP_011302806.1 hypothetical protein -
AL528_RS07370 1487425..1488810 + 1386 WP_011302807.1 class II fumarate hydratase -
AL528_RS07375 1489013..1489840 - 828 WP_011302808.1 RluA family pseudouridine synthase -
AL528_RS07380 1490025..1491140 + 1116 WP_011302809.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7056.51 Da        Isoelectric Point: 3.8237

>T60189 WP_011302805.1 NZ_CP014113:1486289-1486474 [Staphylococcus saprophyticus]
MSLDKNQNNLHRDELESENAMVDDLEDVVELGKEMEQISEENDEDKLDKSHDPAVRSDLNE

Download         Length: 186 bp

>T60189 NZ_CP014113:1486289-1486474 [Staphylococcus saprophyticus]
ATGAGTTTAGATAAAAATCAAAATAATCTACATCGTGATGAATTAGAGTCAGAAAACGCGATGGTTGATGATTTAGAGGA
TGTCGTAGAATTAGGAAAAGAAATGGAACAAATCTCTGAAGAAAATGATGAAGATAAATTAGATAAATCACATGACCCAG
CAGTACGTTCCGATTTAAATGAATAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22279.11 Da        Isoelectric Point: 4.8524

>AT60189 WP_011302804.1 NZ_CP014113:1485668-1486267 [Staphylococcus saprophyticus]
MAMNFKVLENEQVVAEYAADILRKQFNNNPTTIAGVHLSSDNAPVLDELKKNVDKHAVDFSQINILDYDNNKSYFEALGV
PEGQIFNVSFGEDTESFIKDKIKTKENKGKLITQVLSIDTNGKLDVSVNQGLFSAREVILIITGSDKKEVVHKLYEENGK
TSFEPSDLKAHRMVNVILDEAAAEGLPEDVRHYFTARFA

Download         Length: 600 bp

>AT60189 NZ_CP014113:1485668-1486267 [Staphylococcus saprophyticus]
ATGGCAATGAACTTTAAAGTTTTAGAAAATGAACAAGTTGTAGCGGAATATGCTGCAGATATCTTAAGAAAACAATTTAA
CAACAATCCAACAACAATTGCTGGCGTACACCTTTCAAGTGACAATGCACCAGTATTGGATGAATTAAAGAAAAATGTTG
ATAAACATGCAGTAGATTTTAGTCAAATTAATATTCTGGATTATGATAACAATAAATCATACTTTGAAGCACTTGGTGTT
CCAGAAGGCCAAATCTTCAATGTTTCATTTGGTGAAGATACGGAATCATTTATTAAAGATAAAATCAAAACTAAAGAAAA
TAAAGGGAAATTGATTACACAAGTACTTTCTATTGATACAAATGGTAAATTAGATGTAAGTGTGAATCAAGGTTTATTCT
CGGCACGTGAAGTTATTTTAATTATTACAGGTAGCGATAAAAAAGAAGTCGTTCATAAACTTTATGAAGAAAATGGTAAA
ACAAGTTTTGAACCTTCAGATTTAAAAGCGCACCGTATGGTTAATGTTATTTTAGATGAAGCGGCTGCTGAAGGTTTACC
AGAAGATGTTAGACATTATTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HKL3

Antitoxin

Source ID Structure
AlphaFold DB Q49YQ1

References