Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1334955..1335469 Replicon chromosome
Accession NZ_CP014113
Organism Staphylococcus saprophyticus strain FDAARGOS_168

Toxin (Protein)


Gene name TsdT Uniprot ID A0A380HLI4
Locus tag AL528_RS06485 Protein ID WP_002482741.1
Coordinates 1335263..1335469 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q49Z35
Locus tag AL528_RS06480 Protein ID WP_002482740.1
Coordinates 1334955..1335248 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL528_RS06455 1330117..1330908 + 792 WP_047503196.1 hydroxyethylthiazole kinase -
AL528_RS06460 1330908..1331546 + 639 WP_011302689.1 thiamine phosphate synthase -
AL528_RS06465 1331634..1332503 + 870 WP_011302690.1 membrane protein insertase YidC -
AL528_RS06470 1332585..1333193 - 609 WP_172969239.1 HD domain-containing protein -
AL528_RS06475 1333328..1334812 - 1485 WP_011302692.1 cardiolipin synthase -
AL528_RS06480 1334955..1335248 + 294 WP_002482740.1 copper-sensing transcriptional repressor CsoR Antitoxin
AL528_RS06485 1335263..1335469 + 207 WP_002482741.1 hypothetical protein Toxin
AL528_RS06490 1335683..1335823 + 141 WP_002482742.1 hypothetical protein -
AL528_RS06495 1336116..1337321 - 1206 WP_011302694.1 rod shape-determining protein RodA -
AL528_RS06500 1337570..1338640 + 1071 WP_061050523.1 D-alanine--D-alanine ligase -
AL528_RS06505 1338653..1340008 + 1356 WP_047503189.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 8052.33 Da        Isoelectric Point: 4.3776

>T60187 WP_002482741.1 NZ_CP014113:1335263-1335469 [Staphylococcus saprophyticus]
MQSKVIYIAELYNEKQKLQIEERLMKLYGVFKVSIDIEEGAIFVDFETPANLNNLEKEVYDLGYKIIY

Download         Length: 207 bp

>T60187 NZ_CP014113:1335263-1335469 [Staphylococcus saprophyticus]
ATGCAATCAAAAGTTATTTATATTGCTGAACTTTATAATGAGAAGCAAAAATTACAAATTGAAGAAAGATTAATGAAACT
TTATGGTGTGTTTAAAGTTAGTATAGATATAGAAGAAGGCGCAATCTTTGTAGATTTTGAAACGCCTGCAAATTTGAATA
ATTTAGAAAAAGAAGTGTACGATTTAGGTTATAAAATAATTTATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11221.90 Da        Isoelectric Point: 6.3282

>AT60187 WP_002482740.1 NZ_CP014113:1334955-1335248 [Staphylococcus saprophyticus]
MTEIQKAHHSEEIKANLKSRLNRIEGQVKAINRMVEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEQGHE
QEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT60187 NZ_CP014113:1334955-1335248 [Staphylococcus saprophyticus]
ATGACTGAAATACAAAAAGCGCATCATTCAGAAGAAATAAAAGCAAATTTAAAATCAAGACTTAATAGAATCGAAGGTCA
AGTTAAAGCCATAAATCGTATGGTAGAGGAAGATGTGTACTGTGACGATGTGCTTACACAAATAAGAGCTACGCGATCCG
CATTAAATAGTGTCGCTACTAAATTATTAGATCATCATATGAAAAGTTGTATTATGGATAAAGTTGAACAGGGTCATGAA
CAAGAAGCGATGGAAGAACTACTTGTAACTTTTCAAAAATTGATGAAGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HLI4

Antitoxin

Source ID Structure
AlphaFold DB A0A380HKS9

References