Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2400888..2401542 Replicon chromosome
Accession NZ_CP014111
Organism Escherichia coli strain FDAARGOS_144

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag AL502_RS13285 Protein ID WP_000244765.1
Coordinates 2400888..2401295 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag AL502_RS13290 Protein ID WP_000354046.1
Coordinates 2401276..2401542 (-) Length 89 a.a.

Genomic Context


AL502_RS13280AL502_RS13295AL502_RS13310AL502_RS13265AL502_RS13270AL502_RS13275AL502_RS13285AL502_RS13290AL502_RS13300AL502_RS13305
Location: 2400327..2400848 (522 bp)
Type: Others
Protein ID: WP_001055874.1
Location: 2401785..2402765 (981 bp)
Type: Others
Protein ID: WP_000886080.1
Location: 2404021..2405454 (1434 bp)
Type: Others
Protein ID: WP_001339296.1
Location: 2396845..2398578 (1734 bp)
Type: Others
Protein ID: WP_000813195.1
Location: 2398584..2399294 (711 bp)
Type: Others
Protein ID: WP_000715230.1
Location: 2399319..2400215 (897 bp)
Type: Others
Protein ID: WP_000806638.1
Location: 2400888..2401295 (408 bp)
Type: Toxin
Protein ID: WP_000244765.1
Location: 2401276..2401542 (267 bp)
Type: Antitoxin
Protein ID: WP_000354046.1
Location: 2402842..2403501 (660 bp)
Type: Others
Protein ID: WP_000250275.1
Location: 2403665..2403976 (312 bp)
Type: Others
Protein ID: WP_001525592.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AL502_RS132652396845..2398578-1734WP_000813195.1single-stranded-DNA-specific exonuclease RecJ-
AL502_RS132702398584..2399294-711WP_000715230.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
AL502_RS132752399319..2400215-897WP_000806638.1site-specific tyrosine recombinase XerD-
AL502_RS132802400327..2400848+522WP_001055874.1flavodoxin FldB-
AL502_RS132852400888..2401295-408WP_000244765.1protein YgfXToxin
AL502_RS132902401276..2401542-267WP_000354046.1FAD assembly factor SdhEAntitoxin
AL502_RS132952401785..2402765+981WP_000886080.1tRNA-modifying protein YgfZ-
AL502_RS133002402842..2403501-660WP_000250275.1hemolysin III family protein-
AL502_RS133052403665..2403976-312WP_001525592.1N(4)-acetylcytidine aminohydrolase-
AL502_RS133102404021..2405454+1434WP_001339296.16-phospho-beta-glucosidase BglA-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-131)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T60161 WP_000244765.1 NZ_CP014111:c2401295-2400888 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T60161 NZ_CP014111:c2401295-2400888 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT60161 WP_000354046.1 NZ_CP014111:c2401542-2401276 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT60161 NZ_CP014111:c2401542-2401276 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A454A7D7


Antitoxin

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Source
ID
Structure
PDB6B58
PDB1X6I
PDB1X6J
PDB6C12
AlphaFold DBA0A7U9QD57

References