Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 2400888..2401542 | Replicon | chromosome |
Accession | NZ_CP014111 | ||
Organism | Escherichia coli strain FDAARGOS_144 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | F4T2L4 |
Locus tag | AL502_RS13285 | Protein ID | WP_000244765.1 |
Coordinates | 2400888..2401295 (-) | Length | 136 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | S1PPB1 |
Locus tag | AL502_RS13290 | Protein ID | WP_000354046.1 |
Coordinates | 2401276..2401542 (-) | Length | 89 a.a. |
Genomic Context
Location: 2400327..2400848 (522 bp)
Type: Others
Protein ID: WP_001055874.1
Type: Others
Protein ID: WP_001055874.1
Location: 2401785..2402765 (981 bp)
Type: Others
Protein ID: WP_000886080.1
Type: Others
Protein ID: WP_000886080.1
Location: 2404021..2405454 (1434 bp)
Type: Others
Protein ID: WP_001339296.1
Type: Others
Protein ID: WP_001339296.1
Location: 2396845..2398578 (1734 bp)
Type: Others
Protein ID: WP_000813195.1
Type: Others
Protein ID: WP_000813195.1
Location: 2398584..2399294 (711 bp)
Type: Others
Protein ID: WP_000715230.1
Type: Others
Protein ID: WP_000715230.1
Location: 2399319..2400215 (897 bp)
Type: Others
Protein ID: WP_000806638.1
Type: Others
Protein ID: WP_000806638.1
Location: 2400888..2401295 (408 bp)
Type: Toxin
Protein ID: WP_000244765.1
Type: Toxin
Protein ID: WP_000244765.1
Location: 2401276..2401542 (267 bp)
Type: Antitoxin
Protein ID: WP_000354046.1
Type: Antitoxin
Protein ID: WP_000354046.1
Location: 2402842..2403501 (660 bp)
Type: Others
Protein ID: WP_000250275.1
Type: Others
Protein ID: WP_000250275.1
Location: 2403665..2403976 (312 bp)
Type: Others
Protein ID: WP_001525592.1
Type: Others
Protein ID: WP_001525592.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AL502_RS13265 | 2396845..2398578 | - | 1734 | WP_000813195.1 | single-stranded-DNA-specific exonuclease RecJ | - |
AL502_RS13270 | 2398584..2399294 | - | 711 | WP_000715230.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
AL502_RS13275 | 2399319..2400215 | - | 897 | WP_000806638.1 | site-specific tyrosine recombinase XerD | - |
AL502_RS13280 | 2400327..2400848 | + | 522 | WP_001055874.1 | flavodoxin FldB | - |
AL502_RS13285 | 2400888..2401295 | - | 408 | WP_000244765.1 | protein YgfX | Toxin |
AL502_RS13290 | 2401276..2401542 | - | 267 | WP_000354046.1 | FAD assembly factor SdhE | Antitoxin |
AL502_RS13295 | 2401785..2402765 | + | 981 | WP_000886080.1 | tRNA-modifying protein YgfZ | - |
AL502_RS13300 | 2402842..2403501 | - | 660 | WP_000250275.1 | hemolysin III family protein | - |
AL502_RS13305 | 2403665..2403976 | - | 312 | WP_001525592.1 | N(4)-acetylcytidine aminohydrolase | - |
AL502_RS13310 | 2404021..2405454 | + | 1434 | WP_001339296.1 | 6-phospho-beta-glucosidase BglA | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 16043.95 Da Isoelectric Point: 11.5202
>T60161 WP_000244765.1 NZ_CP014111:c2401295-2400888 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
Download Length: 408 bp
>T60161 NZ_CP014111:c2401295-2400888 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10547.12 Da Isoelectric Point: 5.1599
>AT60161 WP_000354046.1 NZ_CP014111:c2401542-2401276 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI
Download Length: 267 bp
>AT60161 NZ_CP014111:c2401542-2401276 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A454A7D7 |
Antitoxin
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Source | ID | Structure |
---|---|---|
PDB | 6B58 | |
PDB | 1X6I | |
PDB | 1X6J | |
PDB | 6C12 | |
AlphaFold DB | A0A7U9QD57 |