Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1386969..1387800 Replicon chromosome
Accession NZ_CP014111
Organism Escherichia coli strain FDAARGOS_144

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag AL502_RS08285 Protein ID WP_000854815.1
Coordinates 1387426..1387800 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag AL502_RS08280 Protein ID WP_001280918.1
Coordinates 1386969..1387337 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL502_RS08235 1382560..1383237 + 678 WP_001362823.1 hypothetical protein -
AL502_RS08240 1383253..1383663 + 411 WP_022296236.1 hypothetical protein -
AL502_RS08250 1383884..1384702 + 819 WP_001542275.1 DUF945 domain-containing protein -
AL502_RS08255 1384702..1384947 + 246 WP_001164966.1 hypothetical protein -
AL502_RS08260 1385041..1385514 + 474 WP_001542276.1 antirestriction protein -
AL502_RS08265 1385530..1386006 + 477 WP_001186200.1 RadC family protein -
AL502_RS08270 1386069..1386290 + 222 WP_000692345.1 DUF987 domain-containing protein -
AL502_RS08275 1386309..1386953 + 645 WP_000086752.1 hypothetical protein -
AL502_RS08280 1386969..1387337 + 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AL502_RS08285 1387426..1387800 + 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
AL502_RS08290 1387797..1387991 + 195 WP_000988600.1 hypothetical protein -
AL502_RS26235 1388004..1388117 + 114 WP_001161660.1 DUF957 domain-containing protein -
AL502_RS08295 1388406..1388552 - 147 Protein_1378 transposase domain-containing protein -
AL502_RS08300 1388606..1388788 + 183 WP_001296208.1 hypothetical protein -
AL502_RS08305 1388889..1389218 - 330 WP_000450409.1 DUF496 family protein -
AL502_RS08310 1389390..1390448 - 1059 WP_021576020.1 FUSC family protein -
AL502_RS08315 1390646..1391119 - 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
AL502_RS08320 1391238..1392404 - 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T60158 WP_000854815.1 NZ_CP014111:1387426-1387800 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T60158 NZ_CP014111:1387426-1387800 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT60158 WP_001280918.1 NZ_CP014111:1386969-1387337 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT60158 NZ_CP014111:1386969-1387337 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References