Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1193223..1193707 Replicon chromosome
Accession NZ_CP014099
Organism Shigella sonnei strain FDAARGOS_90

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A377EAU1
Locus tag AL477_RS06825 Protein ID WP_014334020.1
Coordinates 1193417..1193707 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A376K4R9
Locus tag AL477_RS06820 Protein ID WP_005142544.1
Coordinates 1193223..1193417 (+) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL477_RS06780 (1188418) 1188418..1188774 - 357 WP_005140877.1 hypothetical protein -
AL477_RS06785 (1188832) 1188832..1189254 - 423 WP_001151171.1 DUF977 family protein -
AL477_RS06790 (1189270) 1189270..1189995 - 726 WP_000450631.1 DUF1627 domain-containing protein -
AL477_RS06795 (1190017) 1190017..1190763 - 747 WP_000788740.1 ATP-binding protein -
AL477_RS06800 (1190770) 1190770..1191834 - 1065 WP_001262380.1 hypothetical protein -
AL477_RS06805 (1191906) 1191906..1192331 - 426 WP_000693826.1 toxin YdaT family protein -
AL477_RS06810 (1192328) 1192328..1192591 - 264 WP_001048456.1 helix-turn-helix transcriptional regulator -
AL477_RS06815 (1192718) 1192718..1193203 + 486 WP_053002468.1 helix-turn-helix domain-containing protein -
AL477_RS06820 (1193223) 1193223..1193417 + 195 WP_005142544.1 hypothetical protein Antitoxin
AL477_RS06825 (1193417) 1193417..1193707 + 291 WP_014334020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL477_RS06830 (1193988) 1193988..1194140 + 153 WP_000379558.1 DUF1391 family protein -
AL477_RS06835 (1194152) 1194152..1194517 + 366 WP_024174355.1 hypothetical protein -
AL477_RS06845 (1195420) 1195420..1196496 + 1077 Protein_1204 molybdopterin dinucleotide binding domain-containing protein -
AL477_RS06850 (1196507) 1196507..1197124 + 618 WP_000213029.1 dimethylsulfoxide reductase subunit B -
AL477_RS06855 (1197126) 1197126..1197980 + 855 WP_000526502.1 dimethyl sulfoxide reductase anchor subunit family protein -
AL477_RS06860 (1198023) 1198023..1198637 + 615 WP_000148710.1 Tat proofreading chaperone DmsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vgrG/tssI / rhs/PAAR / rhs/PAAR / sodB 1056631..1284318 227687
- flank IS/Tn - - 1194665..1195168 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11062.93 Da        Isoelectric Point: 10.2013

>T60126 WP_014334020.1 NZ_CP014099:1193417-1193707 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Download         Length: 291 bp

>T60126 NZ_CP014099:1193417-1193707 [Shigella sonnei]
ATGTTACCCGTTTTATGGCTACCATCTGCTCGTGATGATTTGCGCCAGATCGTAGCCTACATAGCTAAAGAAAATCCCGC
GGCAGCACGCAGAATGAAAATTCGAATTGAAACATCCGTTTTGCCGCTCACAGAGCATCCTTACCTGTATCCTCCAAGCG
AGCGAGTTCTTGGTCTTCGTGAAATTGTAACTCATCCTAACTACATCATCCTTTACCGAGTAACAGCATCAAGCATAGAA
GTAGTAAATATTGTGCATTCTCGAAGACAGTATCCAGGCAAAAACAGTTAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7097.98 Da        Isoelectric Point: 4.1759

>AT60126 WP_005142544.1 NZ_CP014099:1193223-1193417 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Download         Length: 195 bp

>AT60126 NZ_CP014099:1193223-1193417 [Shigella sonnei]
ATGAGTACAGTCCTTTCCCCAATGGTTTCAGAATTTGAGACAGTTGAGCAAGAAAATAGTTACAACGAATGGCTGCGGGC
CAAAGTAGCAGCAAGCCTCGCGGATCCCCGCCCGGCGATTCCGCATGATGAGGTAATGGCGGAAATGGAACAAATTATTG
CCCAAATTGCTGCTGCAACTCACAGAGGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377EAU1

Antitoxin

Source ID Structure
AlphaFold DB A0A376K4R9

References