Detailed information of TA system TA060120

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1739740..1740299
• Replicon: chromosome
• Accession: NZ_CP014094
• Organism: Vibrio diabolicus strain FDAARGOS_96

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AL552_RS09385
• Protein ID: WP_104969537.1
• Coordinates: 1740021..1740299 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AL552_RS09380
• Protein ID: WP_104969536.1
• Coordinates: 1739740..1740024 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL552_RS09340	1735157..1735480	-	324	WP_104969529.1	divalent cation tolerance protein CutA	-
AL552_RS09350	1736105..1736800	-	696	WP_104969531.1	hypothetical protein	-
AL552_RS09355	1736956..1737477	-	522	WP_104969532.1	hypothetical protein	-
AL552_RS09360	1737509..1737601	-	93	WP_104969533.1	DUF3265 domain-containing protein	-
AL552_RS09365	1737616..1738395	-	780	WP_146107136.1	hypothetical protein	-
AL552_RS09370	1738425..1738514	-	90	WP_072609598.1	DUF3265 domain-containing protein	-
AL552_RS09375	1738540..1739073	-	534	WP_104969535.1	hypothetical protein	-
AL552_RS09380	1739740..1740024	+	285	WP_104969536.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
AL552_RS09385	1740021..1740299	+	279	WP_104969537.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AL552_RS09390	1740328..1740459	-	132	WP_017821410.1	DUF3265 domain-containing protein	-
AL552_RS09400	1741058..1741483	-	426	WP_104969538.1	N-acetyltransferase	-
AL552_RS09405	1741531..1741623	-	93	WP_080766633.1	DUF3265 domain-containing protein	-
AL552_RS09410	1741638..1742126	-	489	WP_104969539.1	DUF523 domain-containing protein	-
AL552_RS09415	1742165..1742314	-	150	WP_104969540.1	DUF3265 domain-containing protein	-
AL552_RS09420	1742825..1743892	-	1068	WP_104969541.1	toll/interleukin-1 receptor domain-containing protein	-
AL552_RS09425	1744427..1744951	-	525	WP_047009865.1	hypothetical protein	-
AL552_RS25450	1745085..1745174	-	90	WP_072833190.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1657924..1780566	122642
	-	inside	Integron	-	-	1667319..1779447	112128

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (1-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-44)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10941.75 Da
• Isoelectric Point: 4.4766

>T60120 WP_104969537.1 NZ_CP014094:1740021-1740299 [Vibrio diabolicus]
MILWEEESLNDREKIFEFLYDFNPEAAEKTDELIEVKVEKLLEQPLLGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPVN

Nucleotide

• Length: 279 bp

>T60120 NZ_CP014094:1740021-1740299 [Vibrio diabolicus]
ATGATTTTATGGGAAGAAGAATCTCTTAACGATCGTGAAAAGATCTTTGAGTTTCTTTATGACTTTAATCCCGAAGCTGC
CGAAAAAACGGATGAACTTATCGAGGTAAAAGTTGAAAAACTTTTGGAACAACCTCTTTTGGGTGTGCAACGCGATGGAA
TTCGAGGGCGCCTACTCATTATCCCTGAAATTTCAATGATCGTATCCTACTGGGTTGAAGGCGATATCATTCGTGTTATG
CGTGTACTTCACCAAAAACAAAAATTCCCCGTGAATTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10939.34 Da
• Isoelectric Point: 9.1865

>AT60120 WP_104969536.1 NZ_CP014094:1739740-1740024 [Vibrio diabolicus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQINLAFEKFDSGKAVFIDHDSAKSR
MAERKAKIRNRGKL

Nucleotide

• Length: 285 bp

>AT60120 NZ_CP014094:1739740-1740024 [Vibrio diabolicus]
ATGGATACTAGAATTCAGTTTCGTGTTGATGAAGAAACTAAACGACTCGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
GTTAAGCGATGCTTGCCGTGAGCTTACCGAGCAACTCGCTGAACAACAAAGAAAAACATTATCCCATGACGCATGGTTAA
CTGAACAAATAAACTTAGCTTTTGAGAAGTTTGACTCAGGAAAAGCCGTTTTTATTGACCACGATTCGGCTAAATCTAGA
ATGGCTGAACGCAAAGCTAAAATCCGTAATCGAGGCAAACTATGA