Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1717695..1718223 Replicon chromosome
Accession NZ_CP014094
Organism Vibrio diabolicus strain FDAARGOS_96

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag AL552_RS09155 Protein ID WP_005377002.1
Coordinates 1717933..1718223 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag AL552_RS09150 Protein ID WP_005377003.1
Coordinates 1717695..1717943 (+) Length 83 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL552_RS09115 1713614..1713706 - 93 WP_104969511.1 DUF3265 domain-containing protein -
AL552_RS09125 1714312..1714818 - 507 WP_104969513.1 hypothetical protein -
AL552_RS09130 1715052..1715459 - 408 WP_104969514.1 OsmC family protein -
AL552_RS09135 1715509..1715601 - 93 WP_192943636.1 DUF3265 domain-containing protein -
AL552_RS09140 1715639..1716163 - 525 WP_192943637.1 GNAT family N-acetyltransferase -
AL552_RS09145 1716286..1717497 - 1212 WP_104969516.1 hypothetical protein -
AL552_RS09150 1717695..1717943 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AL552_RS09155 1717933..1718223 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL552_RS09170 1718855..1718944 - 90 WP_079740870.1 DUF3265 domain-containing protein -
AL552_RS09175 1719513..1719986 - 474 WP_104969518.1 hypothetical protein -
AL552_RS09180 1720141..1720617 - 477 WP_057619450.1 GNAT family N-acetyltransferase -
AL552_RS09185 1720645..1720734 - 90 WP_074190757.1 DUF3265 domain-containing protein -
AL552_RS25445 1720824..1721222 + 399 WP_192943638.1 hypothetical protein -
AL552_RS09205 1721736..1721828 - 93 WP_078511404.1 DUF3265 domain-containing protein -
AL552_RS09210 1721843..1722406 - 564 WP_104969519.1 DUF4145 domain-containing protein -
AL552_RS09215 1722433..1722522 - 90 WP_104970061.1 DUF3265 domain-containing protein -
AL552_RS09220 1722540..1723007 - 468 WP_146107134.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1657924..1780566 122642
- inside Integron - - 1667319..1779447 112128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T60119 WP_005377002.1 NZ_CP014094:1717933-1718223 [Vibrio diabolicus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T60119 NZ_CP014094:1717933-1718223 [Vibrio diabolicus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCAGCTTCAAAACTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTCGGAAAA
CGAGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT60119 WP_005377003.1 NZ_CP014094:1717695-1717943 [Vibrio diabolicus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT60119 NZ_CP014094:1717695-1717943 [Vibrio diabolicus]
ATGACCACTAGAATATTAGCCGATGTTGCTGCAAGCATTACCGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTATGGCGAACCTGTTGCTGTATTGAACCGAAATGAGCCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A347UR03


Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References