Detailed information of TA system TA060106

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1380242..1380758
• Replicon: chromosome
• Accession: NZ_CP014071
• Organism: Klebsiella quasipneumoniae strain FDAARGOS_93

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AL473_RS07020
• Protein ID: WP_004206511.1
• Coordinates: 1380474..1380758 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: AL473_RS07015
• Protein ID: WP_002886901.1
• Coordinates: 1380242..1380484 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL473_RS07000	1376272..1377012	+	741	WP_004206507.1	KDGP aldolase family protein	-
AL473_RS07005	1377080..1378231	+	1152	WP_004206508.1	lactonase family protein	-
AL473_RS07010	1378254..1380164	+	1911	WP_004206509.1	BglG family transcription antiterminator	-
AL473_RS07015	1380242..1380484	+	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
AL473_RS07020	1380474..1380758	+	285	WP_004206511.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AL473_RS07025	1380762..1381226	-	465	WP_004206512.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
AL473_RS07030	1381537..1383675	-	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
AL473_RS07035	1384061..1385716	-	1656	WP_004206514.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11163.01 Da
• Isoelectric Point: 10.4599

>T60106 WP_004206511.1 NZ_CP014071:1380474-1380758 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCDKIKLKASGYRLVYQVRDRVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T60106 NZ_CP014071:1380474-1380758 [Klebsiella quasipneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCTTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTGCCGGATTGCGACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGCTGGTGTATCAAGTACGAGATAGGGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT60106 WP_002886901.1 NZ_CP014071:1380242-1380484 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT60106 NZ_CP014071:1380242-1380484 [Klebsiella quasipneumoniae]
ATGGCCACGCTCAACGTTCGGCTGGATGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGCGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAGCGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0