Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1442686..1443340 Replicon chromosome
Accession NZ_CP014070
Organism Citrobacter amalonaticus strain FDAARGOS_165

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Q8D714
Locus tag AL524_RS32570 Protein ID WP_044254016.1
Coordinates 1442933..1443340 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0F6TWP9
Locus tag AL524_RS32565 Protein ID WP_042322123.1
Coordinates 1442686..1442952 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL524_RS32540 1437901..1439334 - 1434 WP_061069609.1 6-phospho-beta-glucosidase BglA -
AL524_RS32545 1439454..1440182 - 729 WP_044264419.1 MurR/RpiR family transcriptional regulator -
AL524_RS32550 1440235..1440546 + 312 WP_042999362.1 N(4)-acetylcytidine aminohydrolase -
AL524_RS32555 1440709..1441368 + 660 WP_044264418.1 hemolysin III family protein -
AL524_RS32560 1441449..1442429 - 981 WP_061069610.1 tRNA-modifying protein YgfZ -
AL524_RS32565 1442686..1442952 + 267 WP_042322123.1 FAD assembly factor SdhE Antitoxin
AL524_RS32570 1442933..1443340 + 408 WP_044254016.1 protein YgfX Toxin
AL524_RS32575 1443441..1443962 - 522 WP_042999366.1 flavodoxin FldB -
AL524_RS32580 1444063..1444959 + 897 WP_042999367.1 site-specific tyrosine recombinase XerD -
AL524_RS32585 1444983..1445696 + 714 WP_042999368.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AL524_RS32590 1445702..1447435 + 1734 WP_042999369.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15863.86 Da        Isoelectric Point: 11.6030

>T60090 WP_044254016.1 NZ_CP014070:1442933-1443340 [Citrobacter amalonaticus]
VVLWQSDLRVSWRAQWLSLLLHGLVAAAILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINARQGEVKLLMDGRLRWQGQ
DWLIVSAPWMIKTGMMLRLRSETGKRQHLWLAADSMDKAEWRDLRRLMMQPSTQG

Download         Length: 408 bp

>T60090 NZ_CP014070:1442933-1443340 [Citrobacter amalonaticus]
GTGGTCCTGTGGCAATCTGATCTCCGCGTCTCATGGCGCGCACAGTGGCTATCACTCCTTCTGCATGGGCTGGTGGCCGC
GGCGATTCTATTAATGCCATGGCCGCTGAGCTACACGCCGCTGTGGTTGATACTGCTTTCGCTGGTGGTGTTTGACTGTG
TCCGCAGCCAGCGGCGAATTAACGCCCGTCAGGGAGAGGTCAAACTTCTGATGGATGGACGACTCCGCTGGCAGGGGCAG
GACTGGCTTATCGTCAGTGCACCGTGGATGATCAAAACCGGCATGATGCTGCGCTTGCGCTCTGAAACCGGTAAACGCCA
GCATTTGTGGCTCGCGGCTGACAGTATGGATAAGGCGGAATGGCGGGATTTACGCCGCCTGATGATGCAACCGTCGACGC
AAGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10544.06 Da        Isoelectric Point: 5.1496

>AT60090 WP_042322123.1 NZ_CP014070:1442686-1442952 [Citrobacter amalonaticus]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT60090 NZ_CP014070:1442686-1442952 [Citrobacter amalonaticus]
ATGGATATTAACAATAAAGCACGTATTCACTGGGCATGCCGACGCGGTATGCGTGAACTCGATATTTCCATCATGCCGTT
TTTCGAACATGAATACGACACGTTGAGTGATGATGAAAAACGTATTTTTATCCGCCTGCTGGAGTGTGATGACCCGGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCAGATGCTGAACTGGAGCAGATGGTACGACTCATCCAGACACGGAAT
CGGGATCGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q8D714

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6TWP9

References