Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 486424..487142 Replicon chromosome
Accession NZ_CP014070
Organism Citrobacter amalonaticus strain FDAARGOS_165

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag AL524_RS27950 Protein ID WP_061069384.1
Coordinates 486822..487142 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A949V1J7
Locus tag AL524_RS27945 Protein ID WP_032294516.1
Coordinates 486424..486780 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL524_RS27915 482722..483156 + 435 WP_061069382.1 hypothetical protein -
AL524_RS27920 483269..484108 + 840 WP_052946562.1 hypothetical protein -
AL524_RS27925 484167..484358 + 192 WP_071605959.1 hypothetical protein -
AL524_RS27930 484801..485622 + 822 WP_061069383.1 DUF945 domain-containing protein -
AL524_RS27935 485692..486162 + 471 WP_032294514.1 DNA repair protein RadC -
AL524_RS27940 486171..486392 + 222 WP_023315134.1 DUF987 domain-containing protein -
AL524_RS27945 486424..486780 + 357 WP_032294516.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AL524_RS27950 486822..487142 + 321 WP_061069384.1 TA system toxin CbtA family protein Toxin
AL524_RS27955 487567..488781 + 1215 WP_061069385.1 tyrosine-type recombinase/integrase -
AL524_RS27965 489392..490503 + 1112 WP_104010281.1 IS3 family transposase -
AL524_RS50305 490515..490793 - 279 WP_146255627.1 hypothetical protein -
AL524_RS27970 490989..491819 - 831 WP_061069387.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 466081..504844 38763


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(6-104)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12182.70 Da        Isoelectric Point: 5.9538

>T60086 WP_061069384.1 NZ_CP014070:486822-487142 [Citrobacter amalonaticus]
MHISTVPTTVTVSSRLSSVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFDLVRVDQKGF
SWQDQEPWITSLDVHRAQFNLGLKRS

Download         Length: 321 bp

>T60086 NZ_CP014070:486822-487142 [Citrobacter amalonaticus]
ATGCATATTTCAACTGTACCGACAACAGTGACGGTTTCGTCACGCCTGTCTTCTGTCCAAGTTTGGCAAAAACTATTAAC
GTATATTTTAGAGCATCATTACGGCCTCACGATCAACGACACACCGTTCAGTAACGATACGACGATTCAGGAACATATAG
AGGCGGGAGTGAATCTTACTGATGCTGTTAATTTTCTTGTGGAACGATTCGATCTTGTGCGCGTTGACCAGAAGGGTTTC
TCCTGGCAGGATCAAGAACCCTGGATAACATCTTTGGATGTTCATCGGGCACAGTTCAACCTTGGCTTGAAACGCTCATA
A

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13118.75 Da        Isoelectric Point: 5.5150

>AT60086 WP_032294516.1 NZ_CP014070:486424-486780 [Citrobacter amalonaticus]
MQSTTLSGTSAENASCLQWGLKRNITPCFGARLVQEGNRLYFLADRAGFNGSFSDEEALSLDQAFPLMTKQLERMLTTGE
LDPRNQHCVTLHHNGLTCEADTLGSYGYVYIAIYPHQL

Download         Length: 357 bp

>AT60086 NZ_CP014070:486424-486780 [Citrobacter amalonaticus]
ATGCAGTCGACCACCTTATCCGGCACATCGGCGGAGAACGCATCCTGCCTTCAGTGGGGTTTAAAACGTAATATCACGCC
ATGCTTCGGCGCTCGCCTGGTACAGGAAGGCAACCGCCTATACTTTTTGGCTGACCGGGCAGGATTTAATGGTTCATTCA
GTGACGAAGAAGCATTGAGTCTGGACCAAGCGTTTCCACTAATGACGAAACAGCTTGAGCGGATGCTGACCACTGGCGAG
CTTGATCCTCGCAACCAGCACTGCGTCACACTGCATCACAATGGACTTACTTGTGAAGCTGACACTCTTGGCTCTTATGG
ATACGTTTATATCGCCATTTATCCCCATCAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References