Detailed information of TA system TA060080

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 3920555..3921096
• Replicon: chromosome
• Accession: NZ_CP014065
• Organism: Achromobacter xylosoxidans strain FDAARGOS_162

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AL520_RS18200
• Protein ID: WP_054415989.1
• Coordinates: 3920821..3921096 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A5K4YC22
• Locus tag: AL520_RS18195
• Protein ID: WP_054415952.1
• Coordinates: 3920555..3920821 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL520_RS18170	3915735..3916409	+	675	WP_104010819.1	hypothetical protein	-
AL520_RS18175	3916508..3918092	+	1585	Protein_3584	lytic murein transglycosylase	-
AL520_RS18180	3918089..3918724	+	636	WP_054415954.1	class I SAM-dependent methyltransferase	-
AL520_RS18185	3918900..3919475	+	576	WP_054415953.1	GNAT family N-acetyltransferase	-
AL520_RS18190	3919472..3919678	+	207	WP_053514712.1	hypothetical protein	-
AL520_RS30225	3919712..3920308	-	597	WP_146074710.1	TonB-dependent receptor	-
AL520_RS18195	3920555..3920821	+	267	WP_054415952.1	ribbon-helix-helix domain-containing protein	Antitoxin
AL520_RS18200	3920821..3921096	+	276	WP_054415989.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AL520_RS18205	3921102..3921539	-	438	WP_054415951.1	acetyltransferase	-
AL520_RS18210	3921552..3923291	-	1740	WP_054415950.1	peptidase M14	-
AL520_RS18215	3923349..3924215	-	867	WP_054415949.1	ABC transporter permease	-
AL520_RS18220	3924221..3925144	-	924	WP_006385014.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (8-45)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10681.46 Da
• Isoelectric Point: 10.3377

>T60080 WP_054415989.1 NZ_CP014065:3920821-3921096 [Achromobacter xylosoxidans]
MEMKWTSKALSDLARLHEFLAAVNRPAAVRAVQALVKASSVLPTNSRIGEQLFQFEPREVRRILVGEYEIRYEILDSIIY
VLRLWHTREKR

Nucleotide

• Length: 276 bp

>T60080 NZ_CP014065:3920821-3921096 [Achromobacter xylosoxidans]
ATGGAAATGAAGTGGACCAGCAAGGCGCTTTCCGATCTGGCGCGCTTGCATGAATTCCTGGCGGCAGTGAATAGGCCCGC
GGCTGTACGGGCTGTGCAAGCGTTGGTCAAGGCTTCAAGTGTTTTGCCGACCAACTCCCGCATTGGCGAGCAGCTATTTC
AGTTCGAACCGCGCGAGGTACGCAGGATATTGGTCGGGGAGTACGAAATACGTTACGAGATCCTGGATTCGATCATCTAC
GTATTGCGACTGTGGCACACCCGGGAGAAACGCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9714.01 Da
• Isoelectric Point: 4.5580

>AT60080 WP_054415952.1 NZ_CP014065:3920555-3920821 [Achromobacter xylosoxidans]
MSPATKVLTAHVPLPLAEKVDQMAARLDRSRGWIVKQALSAWIAQEEERDKLTQQALDDVDAGRIVDDQAVQAWAESLGS
DQPLPLPR

Nucleotide

• Length: 267 bp

>AT60080 NZ_CP014065:3920555-3920821 [Achromobacter xylosoxidans]
ATGAGTCCCGCAACCAAGGTGTTGACCGCACATGTGCCGCTTCCGTTGGCCGAGAAGGTCGATCAGATGGCTGCGCGCCT
GGACCGATCTCGCGGCTGGATCGTGAAGCAGGCTCTGTCCGCTTGGATTGCCCAAGAGGAGGAACGTGACAAGCTCACCC
AGCAAGCGCTTGATGACGTGGATGCAGGTCGGATTGTGGATGATCAAGCCGTGCAGGCCTGGGCGGAGAGCCTGGGCTCT
GACCAGCCATTGCCGCTGCCGCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A5K4YC22