Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2765195..2765759 Replicon chromosome
Accession NZ_CP014065
Organism Achromobacter xylosoxidans strain FDAARGOS_162

Toxin (Protein)


Gene name relE Uniprot ID A0A848NLN7
Locus tag AL520_RS12805 Protein ID WP_049075613.1
Coordinates 2765478..2765759 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6IHW1
Locus tag AL520_RS12800 Protein ID WP_020926666.1
Coordinates 2765195..2765491 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL520_RS12780 2760694..2761371 - 678 WP_054417121.1 VOC family protein -
AL520_RS12785 2761501..2762436 - 936 WP_054417122.1 protein translocase subunit SecF -
AL520_RS12790 2762488..2764368 - 1881 WP_054417123.1 protein translocase subunit SecD -
AL520_RS12795 2764482..2764823 - 342 WP_006390891.1 preprotein translocase subunit YajC -
AL520_RS12800 2765195..2765491 + 297 WP_020926666.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AL520_RS12805 2765478..2765759 + 282 WP_049075613.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL520_RS12810 2765809..2766945 - 1137 WP_054417124.1 tRNA guanosine(34) transglycosylase Tgt -
AL520_RS12815 2766942..2767997 - 1056 WP_054417125.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
AL520_RS12820 2768232..2769065 - 834 WP_049075607.1 IclR family transcriptional regulator -
AL520_RS12825 2769186..2770199 + 1014 WP_054417126.1 LLM class flavin-dependent oxidoreductase -
AL520_RS12830 2770222..2770725 + 504 WP_054417127.1 flavin reductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-52)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10257.75 Da        Isoelectric Point: 6.4584

>T60079 WP_049075613.1 NZ_CP014065:2765478-2765759 [Achromobacter xylosoxidans]
VPAVEWSSVARADLLAIVDYISDDNPDAAQRLKDDIETKAAQLPAHPGLYRPGRIAGTREMVVRANYIIVYAADALAVRI
LRILHAAQQWPPQ

Download         Length: 282 bp

>T60079 NZ_CP014065:2765478-2765759 [Achromobacter xylosoxidans]
GTGCCCGCAGTTGAGTGGTCGTCTGTCGCCAGGGCCGATCTGTTGGCCATCGTCGACTACATCTCGGATGACAATCCAGA
CGCTGCCCAGCGTCTGAAAGACGATATTGAAACGAAGGCGGCGCAACTGCCCGCCCATCCCGGGCTGTACCGCCCTGGCA
GGATCGCCGGTACCCGCGAAATGGTCGTCCGCGCGAATTACATCATCGTGTATGCGGCGGATGCGCTGGCCGTGCGGATC
CTGCGCATCCTGCATGCCGCGCAGCAATGGCCGCCGCAGTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10717.24 Da        Isoelectric Point: 7.3208

>AT60079 WP_020926666.1 NZ_CP014065:2765195-2765491 [Achromobacter xylosoxidans]
MPQTSMLHVRVDDKLKADATEKLAEFGLTISDAVRILLTRVAKEGGLPAGLTTDAQAHDAWFRAKVQEALADTGPAVPHQ
QVMDEAQALIDRKRRARS

Download         Length: 297 bp

>AT60079 NZ_CP014065:2765195-2765491 [Achromobacter xylosoxidans]
ATGCCCCAGACCTCGATGCTCCACGTCCGCGTGGACGACAAGCTCAAAGCCGACGCCACCGAAAAGCTGGCCGAATTCGG
CCTGACGATTTCCGACGCCGTGCGCATCCTGCTCACGCGGGTGGCCAAGGAGGGCGGCCTGCCCGCCGGATTGACCACCG
ATGCCCAGGCGCACGACGCGTGGTTCCGCGCCAAAGTTCAGGAAGCCCTGGCCGACACCGGGCCGGCCGTTCCGCACCAG
CAGGTCATGGACGAGGCCCAGGCGCTGATCGACAGGAAGCGCCGTGCCCGCAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A848NLN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6IHW1

References