Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2090316..2091832 Replicon chromosome
Accession NZ_CP014065
Organism Achromobacter xylosoxidans strain FDAARGOS_162

Toxin (Protein)


Gene name HipA1 Uniprot ID A0A5K6E0E7
Locus tag AL520_RS09705 Protein ID WP_054414714.1
Coordinates 2090570..2091832 (+) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag AL520_RS09700 Protein ID WP_006391571.1
Coordinates 2090316..2090573 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL520_RS09690 2086472..2087878 + 1407 WP_054414707.1 DKNYY domain-containing protein -
AL520_RS09695 2088175..2090064 + 1890 WP_054414709.1 molecular chaperone HtpG -
AL520_RS09700 2090316..2090573 + 258 WP_006391571.1 helix-turn-helix transcriptional regulator Antitoxin
AL520_RS09705 2090570..2091832 + 1263 WP_054414714.1 type II toxin-antitoxin system HipA family toxin Toxin
AL520_RS09710 2092028..2093227 + 1200 Protein_1916 MFS transporter -
AL520_RS09715 2093261..2095444 - 2184 WP_054414722.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-74)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 45534.04 Da        Isoelectric Point: 7.0466

>T60078 WP_054414714.1 NZ_CP014065:2090570-2091832 [Achromobacter xylosoxidans]
MSVDALDLYQADRKVGRLFDERPLRLVYDDAWLGWPAAHAIAPDIPLRAGDHASEAVHAFFENLLPEGRLRRFLQVSRHA
TTVFGLLRSVGGDTASGLTIWPQGERPAPPRYRGTTWGEIAARLEDPAQPALVAENADGARISLAGAQDKLLLMVMPDGA
PAWPEGAAPSTHILKPDIRGFDGVWSSALNETLVMQLAACLGLGVAEAGLQPDTRACLVTRYDRAPDGAGGLLRLHQLDL
CQLAGKPSDVKYEADGGPSLAHCRELLRRMGVNAADLKRFLQWVVFNLCVGNNDSHAKNLSVLQTPDGHYRLAPFYDLMC
TALYPGLARNFAFTVGGESRPGHIGRGHLDAMARELGFSPRYVAGVAQALVMALPPALETVQADLARQATAGTESTLIER
LGQWIRANTRKLAKRWELPG

Download         Length: 1263 bp

>T60078 NZ_CP014065:2090570-2091832 [Achromobacter xylosoxidans]
ATGAGTGTCGACGCGCTCGATCTTTACCAGGCGGATCGCAAGGTCGGCCGCCTGTTCGACGAACGGCCCCTGCGTCTCGT
CTATGACGACGCCTGGCTGGGATGGCCCGCGGCGCATGCCATCGCGCCGGACATCCCGCTGCGCGCCGGCGACCATGCCA
GCGAGGCGGTGCATGCCTTCTTCGAAAACCTGTTGCCCGAAGGGCGCCTGCGTCGCTTCCTGCAAGTCAGCCGCCACGCC
ACGACCGTCTTCGGCCTGCTGCGCAGCGTTGGGGGCGATACGGCCAGCGGCCTGACGATATGGCCGCAAGGTGAACGGCC
GGCGCCGCCACGCTATCGCGGCACGACCTGGGGCGAGATCGCGGCGCGCCTGGAGGATCCGGCGCAGCCGGCCCTGGTGG
CCGAGAACGCCGACGGCGCGCGCATTTCATTGGCGGGCGCGCAGGACAAGCTGCTGCTGATGGTCATGCCGGATGGCGCG
CCGGCCTGGCCCGAGGGCGCAGCGCCTTCCACGCATATCCTCAAGCCGGACATCCGCGGATTTGATGGCGTCTGGTCATC
GGCGCTCAATGAAACCCTGGTGATGCAATTGGCGGCGTGCCTGGGGCTGGGCGTGGCCGAGGCTGGCCTGCAACCGGATA
CCCGGGCGTGCCTGGTCACCCGCTACGATCGCGCGCCGGACGGCGCGGGAGGCCTGCTGCGTCTGCATCAGCTCGATCTG
TGCCAGTTGGCAGGCAAGCCCTCGGATGTGAAATACGAAGCGGATGGCGGGCCTTCGCTGGCGCATTGCCGCGAACTGCT
CAGGCGCATGGGCGTCAACGCGGCGGACCTCAAGCGCTTCCTGCAGTGGGTGGTTTTCAACCTTTGCGTCGGCAATAACG
ATAGCCATGCCAAGAACCTGTCCGTGCTGCAAACGCCGGATGGCCATTACCGCCTGGCGCCGTTCTATGACCTGATGTGT
ACCGCGCTGTACCCCGGCCTGGCGCGCAATTTCGCGTTCACCGTGGGGGGCGAGTCCAGGCCCGGCCACATCGGCCGCGG
ACACCTGGATGCCATGGCCCGGGAGCTGGGCTTCAGTCCCCGCTATGTCGCTGGCGTGGCGCAGGCGCTGGTGATGGCAC
TGCCGCCGGCGCTGGAAACGGTGCAGGCCGACCTGGCGCGGCAGGCCACGGCGGGGACGGAAAGCACGCTGATCGAGCGT
CTGGGCCAGTGGATCCGGGCCAATACCCGCAAGCTCGCCAAGCGCTGGGAATTGCCGGGCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 8989.37 Da        Isoelectric Point: 8.8566

>AT60078 WP_006391571.1 NZ_CP014065:2090316-2090573 [Achromobacter xylosoxidans]
MPSPSSADGASIAIHTSAELGELVKDARRAQGLLQTDLAGLSGTGNRFVVDLERGKPTLQLQKVLDMLDLLGLEVRVGPK
RVGRP

Download         Length: 258 bp

>AT60078 NZ_CP014065:2090316-2090573 [Achromobacter xylosoxidans]
ATGCCCTCGCCATCTTCCGCCGATGGAGCCTCCATCGCCATCCACACCTCCGCCGAACTCGGCGAATTGGTGAAGGACGC
GCGCCGCGCGCAAGGGTTGCTGCAAACGGACCTGGCCGGCCTGTCTGGCACCGGCAATCGCTTCGTGGTGGACCTGGAGC
GGGGCAAGCCGACGTTGCAGTTGCAGAAGGTGCTCGACATGCTGGACCTGCTGGGCCTGGAAGTGCGGGTCGGGCCCAAG
CGCGTGGGCCGGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5K6E0E7

Antitoxin

Source ID Structure

References