Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 22888..23365 Replicon chromosome
Accession NZ_CP014064
Organism Staphylococcus aureus strain FDAARGOS_159

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag AL519_RS00370 Protein ID WP_000052076.1
Coordinates 22888..23076 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AL519_RS00375 Protein ID WP_001059690.1
Coordinates 23105..23365 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL519_RS00340 18882..19403 + 522 WP_000824482.1 hypothetical protein -
AL519_RS00345 19744..20430 + 687 WP_000141557.1 thermonuclease family protein -
AL519_RS00350 20787..20987 + 201 WP_001059082.1 cold-shock protein -
AL519_RS00355 21479..21697 - 219 WP_000005886.1 hypothetical protein -
AL519_RS00360 21759..22043 - 285 WP_001004399.1 hypothetical protein -
AL519_RS00365 22131..22700 - 570 WP_001106654.1 hypothetical protein -
AL519_RS00370 22888..23076 - 189 WP_000052076.1 hypothetical protein Toxin
AL519_RS00375 23105..23365 - 261 WP_001059690.1 hypothetical protein Antitoxin
AL519_RS00380 23706..23909 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AL519_RS00385 23906..24142 - 237 WP_000349581.1 hypothetical protein -
AL519_RS00390 24367..24948 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
AL519_RS00395 25021..25638 - 618 Protein_31 amino acid transporter -
AL519_RS00400 25793..26287 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
AL519_RS00405 26686..27108 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
AL519_RS00410 27256..27972 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T60061 WP_000052076.1 NZ_CP014064:c23076-22888 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T60061 NZ_CP014064:c23076-22888 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT60061 WP_001059690.1 NZ_CP014064:c23365-23105 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT60061 NZ_CP014064:c23365-23105 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References