Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 5607514..5608078 Replicon chromosome
Accession NZ_CP014060
Organism Achromobacter xylosoxidans strain FDAARGOS_147

Toxin (Protein)


Gene name relE Uniprot ID F7SVZ5
Locus tag AL504_RS25630 Protein ID WP_006390889.1
Coordinates 5607797..5608078 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6IHW1
Locus tag AL504_RS25625 Protein ID WP_020926666.1
Coordinates 5607514..5607810 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL504_RS25600 5603186..5603497 - 312 WP_061073595.1 helix-turn-helix domain-containing protein -
AL504_RS25610 5603816..5604751 - 936 WP_006390893.1 protein translocase subunit SecF -
AL504_RS25615 5604803..5606683 - 1881 WP_061073597.1 protein translocase subunit SecD -
AL504_RS25620 5606798..5607139 - 342 WP_006390891.1 preprotein translocase subunit YajC -
AL504_RS25625 5607514..5607810 + 297 WP_020926666.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AL504_RS25630 5607797..5608078 + 282 WP_006390889.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL504_RS25635 5608127..5609263 - 1137 WP_061073598.1 tRNA guanosine(34) transglycosylase Tgt -
AL504_RS25640 5609260..5610315 - 1056 WP_006390887.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
AL504_RS25645 5610562..5611419 - 858 WP_061073599.1 IclR family transcriptional regulator -
AL504_RS25650 5611540..5612553 + 1014 WP_061073600.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-52)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10287.78 Da        Isoelectric Point: 6.4584

>T60056 WP_006390889.1 NZ_CP014060:5607797-5608078 [Achromobacter xylosoxidans]
VPAVEWSSVARADLLAIVDYISDDNPDAAQRLKDDIETKAAQLPAHPALYRPGRIAGTREMVVRANYIIVYAADALSVRI
LRILHAAQQWPPQ

Download         Length: 282 bp

>T60056 NZ_CP014060:5607797-5608078 [Achromobacter xylosoxidans]
GTGCCCGCAGTTGAGTGGTCGTCCGTCGCCAGGGCCGACCTGCTGGCCATTGTCGACTACATCTCGGATGACAATCCGGA
CGCTGCCCAGCGTCTGAAAGACGATATTGAAACCAAGGCGGCGCAACTGCCCGCCCATCCCGCGCTGTACCGTCCCGGCA
GGATTGCCGGGACGCGGGAAATGGTCGTCCGCGCGAATTACATCATCGTGTATGCCGCGGACGCGCTCAGCGTGCGGATC
TTGCGCATCCTGCATGCCGCGCAGCAGTGGCCGCCGCAGTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10717.24 Da        Isoelectric Point: 7.3208

>AT60056 WP_020926666.1 NZ_CP014060:5607514-5607810 [Achromobacter xylosoxidans]
MPQTSMLHVRVDDKLKADATEKLAEFGLTISDAVRILLTRVAKEGGLPAGLTTDAQAHDAWFRAKVQEALADTGPAVPHQ
QVMDEAQALIDRKRRARS

Download         Length: 297 bp

>AT60056 NZ_CP014060:5607514-5607810 [Achromobacter xylosoxidans]
ATGCCCCAGACCTCGATGCTCCACGTCCGCGTGGACGACAAGCTCAAAGCCGACGCCACCGAAAAGCTGGCCGAATTCGG
CCTGACGATTTCCGACGCCGTGCGCATTCTGCTGACGCGGGTGGCCAAGGAAGGCGGCCTGCCCGCCGGGCTGACCACCG
ATGCCCAGGCGCACGACGCGTGGTTCCGCGCCAAAGTCCAGGAAGCCCTGGCCGACACCGGGCCGGCCGTTCCGCACCAG
CAGGTCATGGATGAAGCCCAGGCGCTGATCGACAGGAAGCGCCGTGCCCGCAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F7SVZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6IHW1

References