Detailed information of TA system TA060055

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4892111..4893727
• Replicon: chromosome
• Accession: NZ_CP014060
• Organism: Achromobacter xylosoxidans strain FDAARGOS_147

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: AL504_RS22370
• Protein ID: WP_061073190.1
• Coordinates: 4892375..4893727 (+)
• Length: 451 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0X8P223
• Locus tag: AL504_RS22365
• Protein ID: WP_061073189.1
• Coordinates: 4892111..4892371 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL504_RS22340	4887478..4888131	-	654	WP_061073185.1	2-dehydro-3-deoxy-6-phosphogalactonate aldolase	-
AL504_RS22345	4888128..4889144	-	1017	WP_035359603.1	2-dehydro-3-deoxygalactonokinase	-
AL504_RS22350	4889383..4890219	+	837	WP_006391560.1	IclR family transcriptional regulator	-
AL504_RS22355	4890336..4890842	+	507	WP_061073187.1	RNA polymerase sigma factor	-
AL504_RS22360	4890914..4891933	+	1020	WP_061073188.1	FecR domain-containing protein	-
AL504_RS22365	4892111..4892371	+	261	WP_061073189.1	helix-turn-helix domain-containing protein	Antitoxin
AL504_RS22370	4892375..4893727	+	1353	WP_061073190.1	type II toxin-antitoxin system HipA family toxin	Toxin
AL504_RS22375	4894012..4897005	+	2994	WP_061073191.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
AL504_RS22380	4897159..4897764	+	606	WP_061073192.1	heme acquisition protein HasAp	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (11-111)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-67)

Sequences

Toxin

Protein

• Length: 451 a.a.
• Molecular weight: 50057.27 Da
• Isoelectric Point: 8.7774

>T60055 WP_061073190.1 NZ_CP014060:4892375-4893727 [Achromobacter xylosoxidans]
MGRRSHTQSLSLWMNGSMVGSWSTRPRLGDILQYADSWVASDQGRPLSLSLPFTPGNQPHRGEAVRAYFENLLPDSRQIR
ERVARRFQARATDAFTLLAEVGRDCVGALQVLPDTASPEDARALNATPLSEGEVAQVLRNTLATPPLAGADATDDDLRIS
IAGAQEKTALLWWDGRWCMPHGATPTSHIFKMPLGRVGNLRVDLSESVENEWLCLEILRAYGLPVARTQPLMFEDMKVLA
VERFDRRWSRQPEGKRWLLRLPQEDMCQATGTPPHLKYEADGGPGMNAIMRLLSTSMNPDRDRRLFFQAQALFWMLAATD
GHAKNFSIFLRPGGAYELTPLYDVLSAYPVMGVGANKLSPFKARMAMAVRTKNPHWKMQDIQRRHWLALGAEYGVVTADG
REAKFVIDDLATRTPEVVRTVRGLLPAGFPESLADSILGGLQSAADRLAR

Nucleotide

• Length: 1353 bp

>T60055 NZ_CP014060:4892375-4893727 [Achromobacter xylosoxidans]
ATGGGGCGTCGTTCACATACTCAGTCCCTGTCGCTCTGGATGAACGGCAGCATGGTCGGCAGCTGGAGCACGCGGCCGCG
CCTTGGCGACATCCTGCAATATGCGGACTCGTGGGTGGCTTCAGACCAAGGCCGGCCGTTGTCGTTGTCCCTACCGTTTA
CACCCGGCAACCAGCCGCATCGAGGCGAAGCCGTTCGTGCCTACTTCGAGAATCTGTTGCCCGACAGCAGGCAGATTCGT
GAACGTGTCGCACGTCGCTTCCAAGCGCGTGCGACTGATGCGTTCACGTTGCTCGCCGAAGTCGGTCGGGACTGCGTGGG
TGCATTGCAAGTGCTGCCGGACACCGCGTCGCCTGAGGATGCGCGCGCCCTGAACGCCACGCCGTTGAGCGAAGGCGAAG
TGGCCCAGGTATTGCGCAACACCCTTGCAACGCCACCGCTGGCCGGAGCGGATGCCACCGATGACGATCTCCGCATTTCC
ATAGCGGGCGCACAGGAGAAAACGGCGTTGCTGTGGTGGGATGGCCGCTGGTGCATGCCCCACGGCGCGACCCCAACCTC
GCACATCTTCAAGATGCCATTGGGCCGGGTTGGCAATCTGCGCGTCGACCTGAGCGAATCCGTCGAGAATGAATGGCTGT
GCCTGGAAATCTTGCGCGCTTACGGGTTGCCGGTAGCGCGCACGCAGCCTCTCATGTTCGAAGACATGAAAGTTCTGGCC
GTCGAACGCTTCGACCGGCGCTGGTCTCGCCAGCCAGAAGGCAAACGCTGGCTCCTGCGCTTGCCGCAGGAAGACATGTG
CCAGGCCACCGGTACGCCGCCTCATTTGAAATACGAGGCTGATGGCGGTCCCGGCATGAATGCCATCATGCGGCTGCTAT
CCACGTCCATGAATCCGGACCGCGATCGGCGTCTCTTTTTCCAGGCGCAGGCGCTTTTCTGGATGCTCGCCGCCACGGAT
GGACACGCGAAGAATTTCAGCATCTTCCTGCGCCCGGGCGGCGCCTACGAACTCACTCCCCTCTACGATGTGCTTTCCGC
CTATCCGGTCATGGGCGTGGGCGCGAACAAGCTGTCGCCGTTCAAAGCAAGAATGGCCATGGCCGTACGCACGAAGAACC
CGCACTGGAAAATGCAGGACATCCAGCGTCGGCACTGGTTGGCGCTCGGTGCCGAGTATGGCGTCGTCACCGCGGATGGG
CGCGAAGCGAAATTCGTGATCGACGATCTGGCGACTCGGACGCCAGAGGTCGTGCGCACGGTTCGTGGCCTGCTTCCAGC
CGGGTTCCCTGAATCCCTCGCGGACAGCATTCTCGGCGGGCTGCAATCCGCGGCCGATAGGCTGGCCCGGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9462.83 Da
• Isoelectric Point: 6.2838

>AT60055 WP_061073189.1 NZ_CP014060:4892111-4892371 [Achromobacter xylosoxidans]
MADYTVRTAEQLPALLQAFRKKAGLTQAAAALRLGVTQQTLSALERNAEKVSADRLLQLLSLLGVELVLRQPEESPTSRQ
TSDLDW

Nucleotide

• Length: 261 bp

>AT60055 NZ_CP014060:4892111-4892371 [Achromobacter xylosoxidans]
ATGGCCGACTACACCGTACGCACCGCGGAGCAACTTCCGGCATTGCTCCAGGCGTTTCGCAAGAAGGCCGGACTGACCCA
GGCGGCCGCCGCGCTGCGCCTGGGCGTTACACAGCAGACACTTTCGGCCTTGGAGCGGAATGCCGAGAAAGTCAGCGCCG
ACCGGCTGCTGCAATTGCTCAGCCTCTTGGGCGTGGAACTTGTGCTGCGCCAGCCGGAAGAGTCACCGACGAGTCGGCAG
ACTTCGGACCTGGATTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0X8P223