Detailed information of TA system TA060054

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 4869916..4870520
• Replicon: chromosome
• Accession: NZ_CP014060
• Organism: Achromobacter xylosoxidans strain FDAARGOS_147

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AL504_RS22265
• Protein ID: WP_081105260.1
• Coordinates: 4869916..4870221 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0X8P236
• Locus tag: AL504_RS22270
• Protein ID: WP_061073175.1
• Coordinates: 4870218..4870520 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL504_RS22235	4864969..4866063	+	1095	WP_192579537.1	hypothetical protein	-
AL504_RS22240	4866192..4866473	-	282	WP_006385706.1	peptidyl-prolyl cis-trans isomerase	-
AL504_RS22245	4866615..4867550	+	936	WP_081105132.1	HNH endonuclease	-
AL504_RS22250	4867616..4868632	-	1017	WP_006391576.1	amino acid ABC transporter substrate-binding protein	-
AL504_RS22255	4868924..4869247	+	324	WP_061073173.1	YXWGXW repeat-containing protein	-
AL504_RS22260	4869279..4869749	-	471	WP_061073174.1	hypothetical protein	-
AL504_RS22265	4869916..4870221	+	306	WP_081105260.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AL504_RS22270	4870218..4870520	+	303	WP_061073175.1	putative addiction module antidote protein	Antitoxin
AL504_RS22280	4870786..4872177	-	1392	WP_061073176.1	purine permease	-
AL504_RS22285	4872322..4873728	+	1407	WP_061073177.1	DKNYY domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-94)

Antitoxin

• Uncharacterized protein HI1420 (3-94)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11345.22 Da
• Isoelectric Point: 11.3291

>T60054 WP_081105260.1 NZ_CP014060:4869916-4870221 [Achromobacter xylosoxidans]
MRFRETVVFSRWISALRDPQAKAHILRRLARAAIGNFGDTRPVGDGISEMRIDVGAGYRVYYSRHGKVVYVLLCGGNKKS
QARDIAAVKRLWAELKGNALK

Nucleotide

• Length: 306 bp

>T60054 NZ_CP014060:4869916-4870221 [Achromobacter xylosoxidans]
CTGAGGTTTCGGGAAACCGTCGTTTTTTCAAGATGGATTTCAGCGTTGCGCGACCCGCAGGCAAAGGCGCATATCCTGCG
CCGGTTGGCCCGGGCGGCAATCGGAAACTTTGGCGATACCAGGCCAGTCGGTGATGGCATCAGCGAAATGCGGATAGATG
TCGGCGCAGGCTACCGCGTCTACTACAGCCGGCACGGGAAGGTGGTGTATGTGCTGCTGTGCGGTGGCAATAAGAAGTCC
CAGGCGCGTGACATTGCGGCCGTAAAACGCCTGTGGGCGGAACTGAAAGGAAATGCACTCAAATGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10730.09 Da
• Isoelectric Point: 5.6447

>AT60054 WP_061073175.1 NZ_CP014060:4870218-4870520 [Achromobacter xylosoxidans]
MTQLRDFDPANYLTDDETIAHYLADAAADTDPDAFLQALGDVARARGIGAIAKETGLARTNLYRVLAPGANPSYLTLRRV
MDALGVSLTAVSRRKDAAHV

Nucleotide

• Length: 303 bp

>AT60054 NZ_CP014060:4870218-4870520 [Achromobacter xylosoxidans]
ATGACCCAACTGCGAGATTTTGATCCGGCGAACTACCTGACCGATGACGAGACCATTGCGCATTATCTGGCCGACGCCGC
CGCGGACACGGATCCGGATGCGTTTCTCCAGGCGCTGGGCGATGTGGCGCGCGCACGCGGCATCGGCGCCATTGCGAAAG
AGACTGGCCTGGCTCGTACCAATCTCTATCGCGTGCTCGCACCGGGGGCCAATCCGAGCTATCTCACGCTGCGTCGGGTG
ATGGATGCGCTGGGGGTGTCGCTCACCGCCGTGTCCAGGCGCAAGGACGCCGCGCACGTATAG

Structures

Antitoxin

• AlphaFold DB: A0A0X8P236