Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RHH
Location 19414..19967 Replicon plasmid unnamed
Accession NZ_CP014059
Organism Achromobacter xylosoxidans strain FDAARGOS_147

Toxin (Protein)


Gene name relE Uniprot ID A0A1L5QZG5
Locus tag AL504_RS00130 Protein ID WP_054471487.1
Coordinates 19674..19967 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6N8S2B8
Locus tag AL504_RS00125 Protein ID WP_054471486.1
Coordinates 19414..19686 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL504_RS00090 14474..15007 + 534 WP_003830783.1 carboxymuconolactone decarboxylase family protein -
AL504_RS00095 15035..15583 + 549 Protein_17 cytochrome P460 family protein -
AL504_RS00100 15657..16257 + 601 Protein_18 uracil-DNA glycosylase family protein -
AL504_RS00110 16441..17325 - 885 WP_003465017.1 LysR family transcriptional regulator -
AL504_RS00115 17421..19148 - 1728 WP_003830779.1 DDE-type integrase/transposase/recombinase -
AL504_RS00125 19414..19686 + 273 WP_054471486.1 CopG family ribbon-helix-helix protein Antitoxin
AL504_RS00130 19674..19967 + 294 WP_054471487.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL504_RS31660 19967..20137 + 171 WP_167370944.1 hypothetical protein -
AL504_RS00135 20134..20508 + 375 WP_061070726.1 hypothetical protein -
AL504_RS00140 20664..20897 - 234 WP_011997484.1 type I toxin-antitoxin system ptaRNA1 family toxin -
AL504_RS00145 20961..21218 - 258 WP_061070727.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..21970 21970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10811.34 Da        Isoelectric Point: 5.1583

>T60053 WP_054471487.1 NZ_CP014059:19674-19967 [Achromobacter xylosoxidans]
VPQVIVTEGAAEGLERCRRFLAVKAPDAARRAGQAIERQFLLLETAPDIGRPFPEMPELRELVIAFGDSGYVALYRHEPA
DDAVYVLAFRHQKEAGY

Download         Length: 294 bp

>T60053 NZ_CP014059:19674-19967 [Achromobacter xylosoxidans]
GTGCCACAAGTAATCGTCACCGAAGGCGCGGCGGAAGGCTTGGAACGATGCCGGCGGTTCCTGGCCGTCAAGGCACCGGA
CGCCGCCAGGCGTGCCGGCCAGGCCATCGAGCGGCAATTCCTGCTGCTGGAGACGGCCCCGGACATTGGCCGGCCGTTCC
CTGAAATGCCCGAGCTGCGCGAGCTGGTGATTGCCTTCGGGGATTCCGGCTATGTGGCCCTGTACCGCCACGAACCGGCC
GACGATGCGGTGTATGTTCTGGCCTTCCGGCACCAGAAAGAGGCGGGCTACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10563.86 Da        Isoelectric Point: 8.0869

>AT60053 WP_054471486.1 NZ_CP014059:19414-19686 [Achromobacter xylosoxidans]
MATSLKIDDTLKGRVQHLASQRRRSPHWIMLEAIQQYVEREEARESFKQEALASWAAYKETGRHLTGQEVRTWLNTWGTN
DERAVPECHK

Download         Length: 273 bp

>AT60053 NZ_CP014059:19414-19686 [Achromobacter xylosoxidans]
ATGGCAACGTCTCTCAAGATCGACGACACGCTGAAAGGTCGCGTCCAGCACCTCGCCAGCCAGCGCCGCCGCTCGCCCCA
CTGGATCATGCTCGAAGCGATCCAGCAGTACGTCGAGCGCGAAGAAGCCCGCGAGAGCTTCAAGCAGGAAGCCTTGGCGT
CCTGGGCGGCCTACAAGGAAACCGGCCGCCACCTGACCGGCCAGGAAGTTCGCACCTGGTTGAACACCTGGGGCACCAAT
GACGAAAGGGCGGTGCCTGAGTGCCACAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L5QZG5

Antitoxin

Source ID Structure
AlphaFold DB A0A6N8S2B8

References