Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 856303..856832 | Replicon | chromosome |
Accession | NZ_CP014057 | ||
Organism | Staphylococcus saprophyticus strain FDAARGOS_137 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | Q49Z22 |
Locus tag | AL494_RS04085 | Protein ID | WP_011302703.1 |
Coordinates | 856470..856832 (+) | Length | 121 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | Q49Z23 |
Locus tag | AL494_RS04080 | Protein ID | WP_011302702.1 |
Coordinates | 856303..856473 (+) | Length | 57 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AL494_RS04055 | 852034..852513 | + | 480 | WP_011302698.1 | PH domain-containing protein | - |
AL494_RS04060 | 852506..854044 | + | 1539 | WP_048787404.1 | PH domain-containing protein | - |
AL494_RS04065 | 854037..854537 | + | 501 | WP_011302700.1 | PH domain-containing protein | - |
AL494_RS04070 | 854601..854951 | + | 351 | WP_002482750.1 | holo-ACP synthase | - |
AL494_RS04075 | 855067..856215 | + | 1149 | WP_011302701.1 | alanine racemase | - |
AL494_RS04080 | 856303..856473 | + | 171 | WP_011302702.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
AL494_RS04085 | 856470..856832 | + | 363 | WP_011302703.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
AL494_RS04090 | 857169..858170 | + | 1002 | WP_011302704.1 | PP2C family protein-serine/threonine phosphatase | - |
AL494_RS04095 | 858249..858575 | + | 327 | WP_011302705.1 | anti-sigma factor antagonist | - |
AL494_RS04100 | 858577..859059 | + | 483 | WP_002482755.1 | anti-sigma B factor RsbW | - |
AL494_RS04105 | 859034..859804 | + | 771 | WP_002482756.1 | RNA polymerase sigma factor SigB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 121 a.a. Molecular weight: 13482.70 Da Isoelectric Point: 10.3173
>T60051 WP_011302703.1 NZ_CP014057:856470-856832 [Staphylococcus saprophyticus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDKKMKEVNNAIDISLGLHTIRSHKA
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDKKMKEVNNAIDISLGLHTIRSHKA
Download Length: 363 bp
>T60051 NZ_CP014057:856470-856832 [Staphylococcus saprophyticus]
ATGATGAGACGTGGTGACGTTTATTTAGCTGATTTATCACCAGTCCAGGGGTCTGAACAAGGGGGAATAAGACCTGTCGT
AATTATACAAAACGATACTGGTAATAAATATAGTCCTACCGTAATTGTAGCCGCAATTACTGGTAGGATAAATAAAGCTA
AAATACCTACACATGTAGAAATAGAAAAAAGTAAATATAAATTAGATAAAGATTCTGTTATATTGCTAGAGCAGATTAGA
ACTTTAGATAAAAATAGGCTGAAAGAAAAATTAACTTATCTTTCTGATAAAAAAATGAAAGAAGTTAATAATGCCATTGA
TATTAGTTTAGGATTACATACTATTAGGAGTCACAAAGCCTGA
ATGATGAGACGTGGTGACGTTTATTTAGCTGATTTATCACCAGTCCAGGGGTCTGAACAAGGGGGAATAAGACCTGTCGT
AATTATACAAAACGATACTGGTAATAAATATAGTCCTACCGTAATTGTAGCCGCAATTACTGGTAGGATAAATAAAGCTA
AAATACCTACACATGTAGAAATAGAAAAAAGTAAATATAAATTAGATAAAGATTCTGTTATATTGCTAGAGCAGATTAGA
ACTTTAGATAAAAATAGGCTGAAAGAAAAATTAACTTATCTTTCTGATAAAAAAATGAAAGAAGTTAATAATGCCATTGA
TATTAGTTTAGGATTACATACTATTAGGAGTCACAAAGCCTGA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6332.00 Da Isoelectric Point: 4.0121
>AT60051 WP_011302702.1 NZ_CP014057:856303-856473 [Staphylococcus saprophyticus]
MASFNQSRIHNIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE
MASFNQSRIHNIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE
Download Length: 171 bp
>AT60051 NZ_CP014057:856303-856473 [Staphylococcus saprophyticus]
ATGGCAAGTTTCAACCAAAGTAGAATTCATAATATAGAACAACTTTTAAAAGAAGGCTATTCTCAAATGGCTGATTTGAA
CCTCTCCCTCGCAGCAGAAGCATTTCCGTTTGAATGTGAAGCTTGTGATTGCAACGAAGTATATATTAGCTCCAAGAATA
ATAATGAATGA
ATGGCAAGTTTCAACCAAAGTAGAATTCATAATATAGAACAACTTTTAAAAGAAGGCTATTCTCAAATGGCTGATTTGAA
CCTCTCCCTCGCAGCAGAAGCATTTCCGTTTGAATGTGAAGCTTGTGATTGCAACGAAGTATATATTAGCTCCAAGAATA
ATAATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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