Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 856303..856832 Replicon chromosome
Accession NZ_CP014057
Organism Staphylococcus saprophyticus strain FDAARGOS_137

Toxin (Protein)


Gene name mazF Uniprot ID Q49Z22
Locus tag AL494_RS04085 Protein ID WP_011302703.1
Coordinates 856470..856832 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q49Z23
Locus tag AL494_RS04080 Protein ID WP_011302702.1
Coordinates 856303..856473 (+) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL494_RS04055 852034..852513 + 480 WP_011302698.1 PH domain-containing protein -
AL494_RS04060 852506..854044 + 1539 WP_048787404.1 PH domain-containing protein -
AL494_RS04065 854037..854537 + 501 WP_011302700.1 PH domain-containing protein -
AL494_RS04070 854601..854951 + 351 WP_002482750.1 holo-ACP synthase -
AL494_RS04075 855067..856215 + 1149 WP_011302701.1 alanine racemase -
AL494_RS04080 856303..856473 + 171 WP_011302702.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
AL494_RS04085 856470..856832 + 363 WP_011302703.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AL494_RS04090 857169..858170 + 1002 WP_011302704.1 PP2C family protein-serine/threonine phosphatase -
AL494_RS04095 858249..858575 + 327 WP_011302705.1 anti-sigma factor antagonist -
AL494_RS04100 858577..859059 + 483 WP_002482755.1 anti-sigma B factor RsbW -
AL494_RS04105 859034..859804 + 771 WP_002482756.1 RNA polymerase sigma factor SigB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-109)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 121 a.a.        Molecular weight: 13482.70 Da        Isoelectric Point: 10.3173

>T60051 WP_011302703.1 NZ_CP014057:856470-856832 [Staphylococcus saprophyticus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDKKMKEVNNAIDISLGLHTIRSHKA

Download         Length: 363 bp

>T60051 NZ_CP014057:856470-856832 [Staphylococcus saprophyticus]
ATGATGAGACGTGGTGACGTTTATTTAGCTGATTTATCACCAGTCCAGGGGTCTGAACAAGGGGGAATAAGACCTGTCGT
AATTATACAAAACGATACTGGTAATAAATATAGTCCTACCGTAATTGTAGCCGCAATTACTGGTAGGATAAATAAAGCTA
AAATACCTACACATGTAGAAATAGAAAAAAGTAAATATAAATTAGATAAAGATTCTGTTATATTGCTAGAGCAGATTAGA
ACTTTAGATAAAAATAGGCTGAAAGAAAAATTAACTTATCTTTCTGATAAAAAAATGAAAGAAGTTAATAATGCCATTGA
TATTAGTTTAGGATTACATACTATTAGGAGTCACAAAGCCTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6332.00 Da        Isoelectric Point: 4.0121

>AT60051 WP_011302702.1 NZ_CP014057:856303-856473 [Staphylococcus saprophyticus]
MASFNQSRIHNIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE

Download         Length: 171 bp

>AT60051 NZ_CP014057:856303-856473 [Staphylococcus saprophyticus]
ATGGCAAGTTTCAACCAAAGTAGAATTCATAATATAGAACAACTTTTAAAAGAAGGCTATTCTCAAATGGCTGATTTGAA
CCTCTCCCTCGCAGCAGAAGCATTTCCGTTTGAATGTGAAGCTTGTGATTGCAACGAAGTATATATTAGCTCCAAGAATA
ATAATGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q49Z22


Antitoxin

Source ID Structure
AlphaFold DB Q49Z23

References