Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 844633..845147 Replicon chromosome
Accession NZ_CP014057
Organism Staphylococcus saprophyticus strain FDAARGOS_137

Toxin (Protein)


Gene name TsdT Uniprot ID A0A380HLI4
Locus tag AL494_RS04025 Protein ID WP_002482741.1
Coordinates 844941..845147 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q49Z35
Locus tag AL494_RS04020 Protein ID WP_002482740.1
Coordinates 844633..844926 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL494_RS03995 839795..840586 + 792 WP_011302688.1 hydroxyethylthiazole kinase -
AL494_RS04000 840586..841224 + 639 WP_011302689.1 thiamine phosphate synthase -
AL494_RS04005 841312..842181 + 870 WP_011302690.1 membrane protein insertase YidC -
AL494_RS04010 842263..842937 - 675 WP_170178158.1 HD domain-containing protein -
AL494_RS04015 843006..844490 - 1485 WP_011302692.1 cardiolipin synthase -
AL494_RS04020 844633..844926 + 294 WP_002482740.1 copper-sensing transcriptional repressor CsoR Antitoxin
AL494_RS04025 844941..845147 + 207 WP_002482741.1 hypothetical protein Toxin
AL494_RS04030 845360..845500 + 141 WP_002482742.1 hypothetical protein -
AL494_RS04035 845793..846998 - 1206 WP_048787403.1 rod shape-determining protein RodA -
AL494_RS04040 847247..848317 + 1071 WP_011302695.1 D-alanine--D-alanine ligase -
AL494_RS04045 848330..849685 + 1356 WP_011302696.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 8052.33 Da        Isoelectric Point: 4.3776

>T60050 WP_002482741.1 NZ_CP014057:844941-845147 [Staphylococcus saprophyticus]
MQSKVIYIAELYNEKQKLQIEERLMKLYGVFKVSIDIEEGAIFVDFETPANLNNLEKEVYDLGYKIIY

Download         Length: 207 bp

>T60050 NZ_CP014057:844941-845147 [Staphylococcus saprophyticus]
ATGCAATCAAAAGTTATTTATATTGCTGAACTTTATAATGAGAAGCAAAAATTACAAATTGAAGAAAGACTAATGAAACT
TTATGGTGTGTTTAAAGTTAGTATAGATATAGAAGAAGGCGCAATCTTTGTAGATTTTGAAACGCCTGCAAATTTGAATA
ATTTAGAAAAAGAAGTGTACGATTTAGGTTATAAAATAATTTATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11221.90 Da        Isoelectric Point: 6.3282

>AT60050 WP_002482740.1 NZ_CP014057:844633-844926 [Staphylococcus saprophyticus]
MTEIQKAHHSEEIKANLKSRLNRIEGQVKAINRMVEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEQGHE
QEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT60050 NZ_CP014057:844633-844926 [Staphylococcus saprophyticus]
ATGACTGAAATACAAAAAGCGCATCATTCAGAAGAAATAAAAGCAAATTTAAAATCAAGACTTAATAGAATCGAAGGTCA
AGTTAAAGCCATAAATCGTATGGTAGAGGAAGATGTGTACTGTGACGATGTGCTTACACAAATAAGAGCTACGCGATCCG
CATTAAATAGTGTCGCTACTAAATTATTAGATCATCATATGAAAAGTTGTATTATGGATAAAGTTGAACAGGGTCATGAA
CAAGAAGCGATGGAAGAACTACTTGTAACTTTTCAAAAATTGATGAAGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HLI4

Antitoxin

Source ID Structure
AlphaFold DB A0A380HKS9

References