60041

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 851338..851866 Replicon chromosome
Accession NZ_CP014053
Organism Vibrio alginolyticus strain FDAARGOS_108

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag AL539_RS05455 Protein ID WP_005377002.1
Coordinates 851576..851866 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag AL539_RS05450 Protein ID WP_005377003.1
Coordinates 851338..851586 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL539_RS26360 846601..846669 - 69 WP_074531725.1 DUF3265 domain-containing protein -
AL539_RS05405 846744..846992 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
AL539_RS05410 846982..847272 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin -
AL539_RS05415 847411..847899 - 489 WP_104975429.1 hypothetical protein -
AL539_RS05420 847896..848309 - 414 WP_050549549.1 hypothetical protein -
AL539_RS05425 848556..849065 - 510 WP_005376997.1 hypothetical protein -
AL539_RS05430 849201..849695 - 495 WP_104975430.1 GNAT family N-acetyltransferase -
AL539_RS05435 849836..850384 - 549 WP_128740525.1 hypothetical protein -
AL539_RS26365 850481..850549 - 69 WP_074531725.1 DUF3265 domain-containing protein -
AL539_RS05440 850624..850872 + 249 Protein_796 type II toxin-antitoxin system Phd/YefM family antitoxin -
AL539_RS05445 850862..851152 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin -
AL539_RS26370 851195..851263 - 69 WP_074531725.1 DUF3265 domain-containing protein -
AL539_RS05450 851338..851586 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AL539_RS05455 851576..851866 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL539_RS05460 851885..851977 - 93 WP_080256826.1 DUF3265 domain-containing protein -
AL539_RS05465 851992..852390 - 399 WP_025539256.1 hypothetical protein -
AL539_RS05470 852514..852942 - 429 WP_104975432.1 GNAT family N-acetyltransferase -
AL539_RS05475 853099..853656 - 558 WP_054730719.1 hypothetical protein -
AL539_RS05480 853684..853776 - 93 WP_005433818.1 DUF3265 domain-containing protein -
AL539_RS05485 853791..854330 - 540 WP_104975434.1 hypothetical protein -
AL539_RS26375 854372..854464 - 93 WP_079767280.1 DUF3265 domain-containing protein -
AL539_RS05490 854492..854779 - 288 WP_015296903.1 type II toxin-antitoxin system RelE/ParE family toxin -
AL539_RS05495 854776..855057 - 282 WP_025553688.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
AL539_RS05500 855148..855237 - 90 WP_077680412.1 DUF3265 domain-containing protein -
AL539_RS05510 855758..855850 - 93 WP_128740527.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 787032..862540 75508
- inside Integron - - 796577..861422 64845


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T60041 WP_005377002.1 NZ_CP014053:851576-851866 [Vibrio alginolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T60041 NZ_CP014053:851576-851866 [Vibrio alginolyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGCTCAACACTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCGCATGTTCCAGCTTCAAAACTCTCTGGAGCTGACAACATGTATAAAATCA
AGCTGCGCCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTGGCAGTCGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCTATGAAAAGGTTAGATGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT60041 WP_005377003.1 NZ_CP014053:851338-851586 [Vibrio alginolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT60041 NZ_CP014053:851338-851586 [Vibrio alginolyticus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
GTACGGCGAACCTGTTGCTGTACTAAACCGAAATGAGCCCGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTATTAGCTATTGCGAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAACATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References