60040

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 846744..847272 Replicon chromosome
Accession NZ_CP014053
Organism Vibrio alginolyticus strain FDAARGOS_108

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag AL539_RS05410 Protein ID WP_005377002.1
Coordinates 846982..847272 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag AL539_RS05405 Protein ID WP_005377003.1
Coordinates 846744..846992 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL539_RS05325 841954..842043 - 90 WP_079324514.1 DUF3265 domain-containing protein -
AL539_RS05330 842061..842339 - 279 WP_033007115.1 hypothetical protein -
AL539_RS05335 842430..842522 - 93 WP_128740523.1 DUF3265 domain-containing protein -
AL539_RS05340 842561..843229 - 669 WP_025769008.1 hypothetical protein -
AL539_RS05345 843272..843364 - 93 WP_080256826.1 DUF3265 domain-containing protein -
AL539_RS05350 843379..843777 - 399 WP_025539256.1 hypothetical protein -
AL539_RS05360 843965..844198 - 234 WP_005377029.1 hypothetical protein -
AL539_RS05365 844228..844320 - 93 WP_074050578.1 DUF3265 domain-containing protein -
AL539_RS05370 844335..844844 - 510 WP_020840826.1 hypothetical protein -
AL539_RS05375 844854..844982 - 129 WP_080996138.1 DUF3265 domain-containing protein -
AL539_RS05390 845585..845980 - 396 WP_104975428.1 DUF3465 domain-containing protein -
AL539_RS05395 846014..846103 - 90 WP_115386423.1 DUF3265 domain-containing protein -
AL539_RS05400 846129..846548 - 420 WP_085761055.1 hypothetical protein -
AL539_RS26360 846601..846669 - 69 WP_074531725.1 DUF3265 domain-containing protein -
AL539_RS05405 846744..846992 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AL539_RS05410 846982..847272 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL539_RS05415 847411..847899 - 489 WP_104975429.1 hypothetical protein -
AL539_RS05420 847896..848309 - 414 WP_050549549.1 hypothetical protein -
AL539_RS05425 848556..849065 - 510 WP_005376997.1 hypothetical protein -
AL539_RS05430 849201..849695 - 495 WP_104975430.1 GNAT family N-acetyltransferase -
AL539_RS05435 849836..850384 - 549 WP_128740525.1 hypothetical protein -
AL539_RS26365 850481..850549 - 69 WP_074531725.1 DUF3265 domain-containing protein -
AL539_RS05440 850624..850872 + 249 Protein_796 type II toxin-antitoxin system Phd/YefM family antitoxin -
AL539_RS05445 850862..851152 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin -
AL539_RS26370 851195..851263 - 69 WP_074531725.1 DUF3265 domain-containing protein -
AL539_RS05450 851338..851586 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
AL539_RS05455 851576..851866 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin -
AL539_RS05460 851885..851977 - 93 WP_080256826.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 787032..862540 75508
- inside Integron - - 796577..861422 64845


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T60040 WP_005377002.1 NZ_CP014053:846982-847272 [Vibrio alginolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T60040 NZ_CP014053:846982-847272 [Vibrio alginolyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTATCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTATCGTAAAGCCATGAAAAGGTTAGATGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT60040 WP_005377003.1 NZ_CP014053:846744-846992 [Vibrio alginolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT60040 NZ_CP014053:846744-846992 [Vibrio alginolyticus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTAAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References