Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-yefM/YoeB-RelB |
| Location | 1418636..1419152 | Replicon | chromosome |
| Accession | NZ_CP014049 | ||
| Organism | Vibrio vulnificus strain FDAARGOS_119 | ||
Toxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | AL549_RS15255 | Protein ID | WP_038940643.1 |
| Coordinates | 1418636..1418905 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A7W4CB60 |
| Locus tag | AL549_RS15260 | Protein ID | WP_005483180.1 |
| Coordinates | 1418898..1419152 (-) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AL549_RS15190 | 1413991..1414359 | - | 369 | WP_026050325.1 | VOC family protein | - |
| AL549_RS15195 | 1414525..1414979 | - | 455 | Protein_1465 | GNAT family N-acetyltransferase | - |
| AL549_RS15205 | 1415143..1415433 | - | 291 | WP_000509889.1 | hypothetical protein | - |
| AL549_RS15215 | 1415628..1415876 | - | 249 | WP_061058643.1 | hypothetical protein | - |
| AL549_RS15220 | 1415924..1416040 | - | 117 | WP_192945284.1 | DUF3265 domain-containing protein | - |
| AL549_RS15225 | 1416037..1416927 | - | 891 | WP_061058616.1 | hypothetical protein | - |
| AL549_RS15230 | 1416954..1417046 | - | 93 | WP_080252013.1 | DUF3265 domain-containing protein | - |
| AL549_RS24060 | 1417794..1418099 | - | 306 | WP_061058669.1 | DUF3265 domain-containing protein | - |
| AL549_RS15250 | 1418075..1418512 | - | 438 | WP_061058608.1 | hypothetical protein | - |
| AL549_RS15255 | 1418636..1418905 | - | 270 | WP_038940643.1 | Txe/YoeB family addiction module toxin | Toxin |
| AL549_RS15260 | 1418898..1419152 | - | 255 | WP_005483180.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| AL549_RS15265 | 1419244..1419366 | - | 123 | WP_104408428.1 | DUF3265 domain-containing protein | - |
| AL549_RS23870 | 1419716..1419844 | - | 129 | WP_123776227.1 | DUF3265 domain-containing protein | - |
| AL549_RS15270 | 1420206..1420316 | - | 111 | WP_086017781.1 | DUF3265 domain-containing protein | - |
| AL549_RS15275 | 1420785..1421417 | - | 633 | WP_061058670.1 | hypothetical protein | - |
| AL549_RS15280 | 1421383..1421565 | - | 183 | WP_192945299.1 | DUF3265 domain-containing protein | - |
| AL549_RS15285 | 1421568..1422202 | - | 635 | Protein_1480 | LysE family translocator | - |
| AL549_RS15290 | 1422218..1422353 | - | 136 | Protein_1481 | DUF3265 domain-containing protein | - |
| AL549_RS15295 | 1422350..1422685 | - | 336 | WP_061058671.1 | hypothetical protein | - |
| AL549_RS15300 | 1422711..1422833 | - | 123 | WP_081090724.1 | DUF3265 domain-containing protein | - |
| AL549_RS15305 | 1423195..1423320 | - | 126 | Protein_1484 | DUF3265 domain-containing protein | - |
| AL549_RS15310 | 1423302..1423781 | - | 480 | WP_061058672.1 | GNAT family N-acetyltransferase | - |
| AL549_RS15315 | 1423806..1423927 | - | 122 | Protein_1486 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1220087..1425467 | 205380 | |
| - | inside | Integron | - | - | 1224520..1425467 | 200947 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10613.97 Da Isoelectric Point: 8.8578
>T60033 WP_038940643.1 NZ_CP014049:c1418905-1418636 [Vibrio vulnificus]
MSSSQRLLSWTDDAWNDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY
MSSSQRLLSWTDDAWNDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY
Download Length: 270 bp
>T60033 NZ_CP014049:c1418905-1418636 [Vibrio vulnificus]
ATGAGTAGTAGTCAGCGTTTACTGTCGTGGACTGATGACGCTTGGAATGACTACCTGTATTGGCAAACTCAAGACAAAAA
AACACTCAAGCGCATCAATAAACTCATCAATGATGTTAAGCGTTCTCCATTTGAGGGCATCGGTAAACCTGAGCCATTGA
AAGAGAACTTATCTGGTTTTTGGTCTCGTCGTATTGATGATACTAATAGGCTTGTTTACGCAGTCGATGACCAGGCCATA
ACGATAATCTCGTGTCGTTACCACTACTAA
ATGAGTAGTAGTCAGCGTTTACTGTCGTGGACTGATGACGCTTGGAATGACTACCTGTATTGGCAAACTCAAGACAAAAA
AACACTCAAGCGCATCAATAAACTCATCAATGATGTTAAGCGTTCTCCATTTGAGGGCATCGGTAAACCTGAGCCATTGA
AAGAGAACTTATCTGGTTTTTGGTCTCGTCGTATTGATGATACTAATAGGCTTGTTTACGCAGTCGATGACCAGGCCATA
ACGATAATCTCGTGTCGTTACCACTACTAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9481.66 Da Isoelectric Point: 5.0623
>AT60033 WP_005483180.1 NZ_CP014049:c1419152-1418898 [Vibrio vulnificus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE
Download Length: 255 bp
>AT60033 NZ_CP014049:c1419152-1418898 [Vibrio vulnificus]
ATGAGAATCGTATCTTTTACTGAAGCAAGAAATGGTCTTAAAGCTGTTTTGGACGGTGTAGTTAATGACGCTGATACAAC
AGTTATTACACGTCGTGATTCTGAGGATGCCGTGGTTATGTCTTTAGACTACTACAATAGCCTTATGGAGACAGTTCATT
TACTACGCTCTCCTCAAAACGTTGAACACCTAAACCGTTCGATAGCACAGTACCGTGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG
ATGAGAATCGTATCTTTTACTGAAGCAAGAAATGGTCTTAAAGCTGTTTTGGACGGTGTAGTTAATGACGCTGATACAAC
AGTTATTACACGTCGTGATTCTGAGGATGCCGTGGTTATGTCTTTAGACTACTACAATAGCCTTATGGAGACAGTTCATT
TACTACGCTCTCCTCAAAACGTTGAACACCTAAACCGTTCGATAGCACAGTACCGTGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|