Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 1397070..1397615 Replicon chromosome
Accession NZ_CP014049
Organism Vibrio vulnificus strain FDAARGOS_119

Toxin (Protein)


Gene name parE Uniprot ID A0A4U2BEW0
Locus tag AL549_RS14950 Protein ID WP_025794194.1
Coordinates 1397319..1397615 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A4U2ER13
Locus tag AL549_RS14945 Protein ID WP_045957228.1
Coordinates 1397070..1397312 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL549_RS14875 1392120..1392248 - 129 WP_081090715.1 DUF3265 domain-containing protein -
AL549_RS14880 1392593..1392760 - 168 WP_081090642.1 DUF3265 domain-containing protein -
AL549_RS14885 1392733..1393062 - 330 WP_013571654.1 hypothetical protein -
AL549_RS14890 1393096..1393188 - 93 WP_079751146.1 DUF3265 domain-containing protein -
AL549_RS14895 1393203..1393613 - 411 WP_025630327.1 cytidine deaminase -
AL549_RS14900 1393632..1393766 - 135 WP_081090714.1 DUF3265 domain-containing protein -
AL549_RS14910 1394242..1394649 - 408 WP_061058654.1 hypothetical protein -
AL549_RS14915 1394745..1395488 - 744 WP_061058655.1 hypothetical protein -
AL549_RS14925 1395592..1395807 - 216 Protein_1417 GFA family protein -
AL549_RS14930 1396133..1396339 - 207 Protein_1418 GFA family protein -
AL549_RS14935 1396341..1396496 - 156 WP_081090716.1 DUF3265 domain-containing protein -
AL549_RS14945 1397070..1397312 + 243 WP_045957228.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AL549_RS14950 1397319..1397615 + 297 WP_025794194.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL549_RS14955 1397668..1398096 - 429 WP_061058657.1 IS200/IS605 family transposase -
AL549_RS14960 1398227..1398319 - 93 WP_081090717.1 DUF3265 domain-containing protein -
AL549_RS14965 1398787..1399323 - 537 WP_061058658.1 hypothetical protein -
AL549_RS14970 1399487..1399825 - 339 WP_061058659.1 hypothetical protein -
AL549_RS14975 1399812..1399976 - 165 WP_081090645.1 DUF3265 domain-containing protein -
AL549_RS14980 1399977..1400309 - 333 WP_061058660.1 hypothetical protein -
AL549_RS14985 1400306..1400449 - 144 WP_081090646.1 DUF3265 domain-containing protein -
AL549_RS14990 1400446..1400871 - 426 WP_045620445.1 hypothetical protein -
AL549_RS14995 1400913..1401035 - 123 WP_080927580.1 DUF3265 domain-containing protein -
AL549_RS15000 1400995..1401654 - 660 WP_061058661.1 hypothetical protein -
AL549_RS15005 1401809..1402177 - 369 WP_025549140.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1220087..1425467 205380
- inside Integron - - 1224520..1425467 200947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-63)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11234.88 Da        Isoelectric Point: 9.6269

>T60031 WP_025794194.1 NZ_CP014049:1397319-1397615 [Vibrio vulnificus]
MQKNKYKLSKLAQAHLRKIKSYTVNNFSEMQWNNYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL

Download         Length: 297 bp

>T60031 NZ_CP014049:1397319-1397615 [Vibrio vulnificus]
ATGCAAAAGAATAAATACAAACTAAGTAAATTGGCTCAGGCTCATTTACGAAAAATTAAAAGCTATACCGTCAACAACTT
TTCTGAAATGCAGTGGAACAACTATAAAGATACATTGCTAACTGGGTTTCAAATGCTTGCCGACAATCCAGCCGTAGGTC
GCAGTTGCGATGAGATTTATCCAAGCGGTTTCTATTTTCCGGTAGGAAAACACACAGCTTACTTTACAAAAGAAGACGGC
TTTATTTTAGTTGTGGCTGTACTTGGTCAATCACAACTCCCACAAAACCACTTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8947.14 Da        Isoelectric Point: 4.7914

>AT60031 WP_045957228.1 NZ_CP014049:1397070-1397312 [Vibrio vulnificus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLKHCFESAKQDLAQGNVVDGEDFLSAL

Download         Length: 243 bp

>AT60031 NZ_CP014049:1397070-1397312 [Vibrio vulnificus]
ATGCACACACTAACAGCAAATGATGCAAAGCGTAACTTTGGTGAGCTGCTTCTAAGCGCCCAACGTGAGCCAGTAAAGAT
TAGCAAAAACAGTAAAGATGCCGTAGTGGTAATGTCTATCAAAGACTATGAAGAACTAGAGGCAATGAAAACTGATTACC
TTAAACATTGTTTCGAGTCAGCTAAACAAGACTTAGCACAAGGCAATGTAGTTGATGGTGAAGATTTCCTAAGCGCCTTG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U2BEW0

Antitoxin

Source ID Structure
AlphaFold DB A0A4U2ER13

References