Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/ParE-YefM |
Location | 1397070..1397615 | Replicon | chromosome |
Accession | NZ_CP014049 | ||
Organism | Vibrio vulnificus strain FDAARGOS_119 |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A4U2BEW0 |
Locus tag | AL549_RS14950 | Protein ID | WP_025794194.1 |
Coordinates | 1397319..1397615 (+) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | A0A4U2ER13 |
Locus tag | AL549_RS14945 | Protein ID | WP_045957228.1 |
Coordinates | 1397070..1397312 (+) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AL549_RS14875 | 1392120..1392248 | - | 129 | WP_081090715.1 | DUF3265 domain-containing protein | - |
AL549_RS14880 | 1392593..1392760 | - | 168 | WP_081090642.1 | DUF3265 domain-containing protein | - |
AL549_RS14885 | 1392733..1393062 | - | 330 | WP_013571654.1 | hypothetical protein | - |
AL549_RS14890 | 1393096..1393188 | - | 93 | WP_079751146.1 | DUF3265 domain-containing protein | - |
AL549_RS14895 | 1393203..1393613 | - | 411 | WP_025630327.1 | cytidine deaminase | - |
AL549_RS14900 | 1393632..1393766 | - | 135 | WP_081090714.1 | DUF3265 domain-containing protein | - |
AL549_RS14910 | 1394242..1394649 | - | 408 | WP_061058654.1 | hypothetical protein | - |
AL549_RS14915 | 1394745..1395488 | - | 744 | WP_061058655.1 | hypothetical protein | - |
AL549_RS14925 | 1395592..1395807 | - | 216 | Protein_1417 | GFA family protein | - |
AL549_RS14930 | 1396133..1396339 | - | 207 | Protein_1418 | GFA family protein | - |
AL549_RS14935 | 1396341..1396496 | - | 156 | WP_081090716.1 | DUF3265 domain-containing protein | - |
AL549_RS14945 | 1397070..1397312 | + | 243 | WP_045957228.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
AL549_RS14950 | 1397319..1397615 | + | 297 | WP_025794194.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
AL549_RS14955 | 1397668..1398096 | - | 429 | WP_061058657.1 | IS200/IS605 family transposase | - |
AL549_RS14960 | 1398227..1398319 | - | 93 | WP_081090717.1 | DUF3265 domain-containing protein | - |
AL549_RS14965 | 1398787..1399323 | - | 537 | WP_061058658.1 | hypothetical protein | - |
AL549_RS14970 | 1399487..1399825 | - | 339 | WP_061058659.1 | hypothetical protein | - |
AL549_RS14975 | 1399812..1399976 | - | 165 | WP_081090645.1 | DUF3265 domain-containing protein | - |
AL549_RS14980 | 1399977..1400309 | - | 333 | WP_061058660.1 | hypothetical protein | - |
AL549_RS14985 | 1400306..1400449 | - | 144 | WP_081090646.1 | DUF3265 domain-containing protein | - |
AL549_RS14990 | 1400446..1400871 | - | 426 | WP_045620445.1 | hypothetical protein | - |
AL549_RS14995 | 1400913..1401035 | - | 123 | WP_080927580.1 | DUF3265 domain-containing protein | - |
AL549_RS15000 | 1400995..1401654 | - | 660 | WP_061058661.1 | hypothetical protein | - |
AL549_RS15005 | 1401809..1402177 | - | 369 | WP_025549140.1 | VOC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 1220087..1425467 | 205380 | |
- | inside | Integron | - | - | 1224520..1425467 | 200947 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11234.88 Da Isoelectric Point: 9.6269
>T60031 WP_025794194.1 NZ_CP014049:1397319-1397615 [Vibrio vulnificus]
MQKNKYKLSKLAQAHLRKIKSYTVNNFSEMQWNNYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL
MQKNKYKLSKLAQAHLRKIKSYTVNNFSEMQWNNYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL
Download Length: 297 bp
>T60031 NZ_CP014049:1397319-1397615 [Vibrio vulnificus]
ATGCAAAAGAATAAATACAAACTAAGTAAATTGGCTCAGGCTCATTTACGAAAAATTAAAAGCTATACCGTCAACAACTT
TTCTGAAATGCAGTGGAACAACTATAAAGATACATTGCTAACTGGGTTTCAAATGCTTGCCGACAATCCAGCCGTAGGTC
GCAGTTGCGATGAGATTTATCCAAGCGGTTTCTATTTTCCGGTAGGAAAACACACAGCTTACTTTACAAAAGAAGACGGC
TTTATTTTAGTTGTGGCTGTACTTGGTCAATCACAACTCCCACAAAACCACTTGTAG
ATGCAAAAGAATAAATACAAACTAAGTAAATTGGCTCAGGCTCATTTACGAAAAATTAAAAGCTATACCGTCAACAACTT
TTCTGAAATGCAGTGGAACAACTATAAAGATACATTGCTAACTGGGTTTCAAATGCTTGCCGACAATCCAGCCGTAGGTC
GCAGTTGCGATGAGATTTATCCAAGCGGTTTCTATTTTCCGGTAGGAAAACACACAGCTTACTTTACAAAAGAAGACGGC
TTTATTTTAGTTGTGGCTGTACTTGGTCAATCACAACTCCCACAAAACCACTTGTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8947.14 Da Isoelectric Point: 4.7914
>AT60031 WP_045957228.1 NZ_CP014049:1397070-1397312 [Vibrio vulnificus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLKHCFESAKQDLAQGNVVDGEDFLSAL
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLKHCFESAKQDLAQGNVVDGEDFLSAL
Download Length: 243 bp
>AT60031 NZ_CP014049:1397070-1397312 [Vibrio vulnificus]
ATGCACACACTAACAGCAAATGATGCAAAGCGTAACTTTGGTGAGCTGCTTCTAAGCGCCCAACGTGAGCCAGTAAAGAT
TAGCAAAAACAGTAAAGATGCCGTAGTGGTAATGTCTATCAAAGACTATGAAGAACTAGAGGCAATGAAAACTGATTACC
TTAAACATTGTTTCGAGTCAGCTAAACAAGACTTAGCACAAGGCAATGTAGTTGATGGTGAAGATTTCCTAAGCGCCTTG
TAA
ATGCACACACTAACAGCAAATGATGCAAAGCGTAACTTTGGTGAGCTGCTTCTAAGCGCCCAACGTGAGCCAGTAAAGAT
TAGCAAAAACAGTAAAGATGCCGTAGTGGTAATGTCTATCAAAGACTATGAAGAACTAGAGGCAATGAAAACTGATTACC
TTAAACATTGTTTCGAGTCAGCTAAACAAGACTTAGCACAAGGCAATGTAGTTGATGGTGAAGATTTCCTAAGCGCCTTG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4U2BEW0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4U2ER13 |