60030

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1327590..1328128 Replicon chromosome
Accession NZ_CP014049
Organism Vibrio vulnificus strain FDAARGOS_119

Toxin (Protein)


Gene name parE Uniprot ID A0A3Q0L5T8
Locus tag AL549_RS14075 Protein ID WP_001247271.1
Coordinates 1327829..1328128 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0F2HR74
Locus tag AL549_RS14070 Protein ID WP_011080384.1
Coordinates 1327590..1327832 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL549_RS13995 1323577..1323696 - 120 Protein_1261 DUF3265 domain-containing protein -
AL549_RS14005 1324073..1324165 - 93 WP_080252013.1 DUF3265 domain-containing protein -
AL549_RS14015 1324662..1324784 - 123 WP_081090691.1 DUF3265 domain-containing protein -
AL549_RS14025 1325069..1325253 - 185 Protein_1264 DUF3265 domain-containing protein -
AL549_RS14030 1325250..1325723 - 474 WP_061058618.1 hypothetical protein -
AL549_RS23980 1325757..1325849 - 93 WP_080264765.1 DUF3265 domain-containing protein -
AL549_RS14040 1325887..1326258 - 372 WP_061059123.1 acyl carrier protein -
AL549_RS14045 1326276..1326398 - 123 WP_072615240.1 DUF3265 domain-containing protein -
AL549_RS14055 1326793..1326876 - 84 WP_080933190.1 DUF3265 domain-containing protein -
AL549_RS14060 1327027..1327344 + 318 WP_072599303.1 YceK/YidQ family lipoprotein -
AL549_RS14065 1327341..1327556 - 216 WP_072615234.1 DUF3265 domain-containing protein -
AL549_RS14070 1327590..1327832 + 243 WP_011080384.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
AL549_RS14075 1327829..1328128 + 300 WP_001247271.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL549_RS14080 1328243..1329016 - 774 WP_061058603.1 hypothetical protein -
AL549_RS14085 1329036..1329158 - 123 WP_081090692.1 DUF3265 domain-containing protein -
AL549_RS14090 1329502..1329579 - 78 WP_072615052.1 DUF3265 domain-containing protein -
AL549_RS14095 1329974..1330102 - 129 WP_081090694.1 DUF3265 domain-containing protein -
AL549_RS14105 1330445..1330585 - 141 WP_081090693.1 DUF3265 domain-containing protein -
AL549_RS14110 1330616..1331341 - 726 WP_072615254.1 GNAT family N-acetyltransferase -
AL549_RS14120 1331577..1332014 - 438 WP_039470159.1 hypothetical protein -
AL549_RS14130 1332190..1332795 - 606 WP_081090681.1 DUF2807 domain-containing protein -
AL549_RS14135 1332836..1332946 - 111 WP_081090695.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1220087..1425467 205380
- inside Integron - - 1224520..1425467 200947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11703.39 Da        Isoelectric Point: 9.9572

>T60030 WP_001247271.1 NZ_CP014049:1327829-1328128 [Vibrio vulnificus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T60030 NZ_CP014049:1327829-1328128 [Vibrio vulnificus]
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACTTCTCGACGTTGGGGTCG
CGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGTTAGCCGAAAACCCTGACATTGGTAAAGCCT
GTGACGAAATTCGCGATGGCTACAGAAAGTTTCCACAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATAGAGATTATCCGTATCCTCCACAAAAGCATGGATGTGAATCCAATTTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8953.88 Da        Isoelectric Point: 4.2213

>AT60030 WP_011080384.1 NZ_CP014049:1327590-1327832 [Vibrio vulnificus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK

Download         Length: 243 bp

>AT60030 NZ_CP014049:1327590-1327832 [Vibrio vulnificus]
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGACGGTTTTATTGCTAATCAAATCCAAAGCGGCCGCTATGG
CTCTGCAAGTGAAGTTATTCGTTCTGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAACACTTTACGCCAGTTGC
TTGTTGAGGGCGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAGAGAAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5T8

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2HR74

References