60029

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 1239286..1239851 Replicon chromosome
Accession NZ_CP014049
Organism Vibrio vulnificus strain FDAARGOS_119

Toxin (Protein)


Gene name relE Uniprot ID A0A0H2MSY5
Locus tag AL549_RS13005 Protein ID WP_015296903.1
Coordinates 1239286..1239573 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3BLE1
Locus tag AL549_RS13010 Protein ID WP_000086647.1
Coordinates 1239570..1239851 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL549_RS23955 1234403..1234825 - 423 WP_061058556.1 hypothetical protein -
AL549_RS12945 1234842..1234964 - 123 WP_072036373.1 DUF3265 domain-containing protein -
AL549_RS12950 1234961..1235386 - 426 WP_045620445.1 hypothetical protein -
AL549_RS12955 1235396..1235539 - 144 WP_081090605.1 DUF3265 domain-containing protein -
AL549_RS12965 1235881..1236028 - 148 Protein_1075 DUF3265 domain-containing protein -
AL549_RS12970 1236090..1236320 + 231 WP_061058557.1 PAS factor family protein -
AL549_RS12975 1236574..1236762 - 189 Protein_1077 hypothetical protein -
AL549_RS12980 1236862..1236999 - 138 WP_072615129.1 DUF3265 domain-containing protein -
AL549_RS12985 1236981..1237460 - 480 WP_039470588.1 GNAT family N-acetyltransferase -
AL549_RS12990 1238087..1238443 - 357 WP_061058558.1 hypothetical protein -
AL549_RS12995 1238452..1238616 - 165 Protein_1081 DUF3265 domain-containing protein -
AL549_RS13000 1238616..1239137 - 522 WP_061058559.1 GNAT family N-acetyltransferase -
AL549_RS23960 1239166..1239258 - 93 WP_192945281.1 DUF3265 domain-containing protein -
AL549_RS13005 1239286..1239573 - 288 WP_015296903.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL549_RS13010 1239570..1239851 - 282 WP_000086647.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AL549_RS13015 1239808..1240053 - 246 WP_081090606.1 DUF3265 domain-containing protein -
AL549_RS23965 1240403..1240561 - 159 WP_072615093.1 DUF3265 domain-containing protein -
AL549_RS13030 1240865..1240993 - 129 Protein_1088 DUF3265 domain-containing protein -
AL549_RS13040 1241336..1241464 - 129 WP_072615096.1 DUF3265 domain-containing protein -
AL549_RS13050 1241830..1241919 - 90 WP_072615095.1 DUF3265 domain-containing protein -
AL549_RS13055 1241961..1242569 - 609 WP_049882204.1 PH domain-containing protein -
AL549_RS13060 1242572..1242706 - 135 WP_072615081.1 DUF3265 domain-containing protein -
AL549_RS13065 1243164..1243514 - 351 WP_038969909.1 hypothetical protein -
AL549_RS13070 1243559..1243648 - 90 WP_072615097.1 DUF3265 domain-containing protein -
AL549_RS13075 1243994..1244083 - 90 WP_072605908.1 DUF3265 domain-containing protein -
AL549_RS13080 1244101..1244733 - 633 WP_072615082.1 DUF1643 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1220087..1425467 205380
- inside Integron - - 1224520..1425467 200947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11003.69 Da        Isoelectric Point: 5.1098

>T60029 WP_015296903.1 NZ_CP014049:c1239573-1239286 [Vibrio vulnificus]
MKVVWSPLALQKLGDAAEFISLDNPPAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV

Download         Length: 288 bp

>T60029 NZ_CP014049:c1239573-1239286 [Vibrio vulnificus]
ATGAAAGTAGTCTGGTCTCCATTAGCACTTCAGAAACTAGGTGATGCAGCGGAGTTTATTTCTTTGGATAATCCACCTGC
GGCAGAGAAGTGGGTAAACGAAGTTTTTGATAAAACTGAACTCCTTGGAAGTATGCCTGAAATGGGGCGGTTTGTTCCTG
AAATGCCCCATACGAATTATCGTGAAATCATCTTTGGTCACTATCGTATTATCTACAGTTTAAGTCACGAAATTCGCGTA
CTAACAGTTCGTAATTGTCGTCAAATTTTATCGGAAGATGACGTGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10398.91 Da        Isoelectric Point: 5.8650

>AT60029 WP_000086647.1 NZ_CP014049:c1239851-1239570 [Vibrio vulnificus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Download         Length: 282 bp

>AT60029 NZ_CP014049:c1239851-1239570 [Vibrio vulnificus]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCTTTATCTGAGTTTCGTGCCGGTGTAGCTTCATACATCAAACAAAT
CAATGAGACTCGTCGTCCATTGGTTATTACGCAACGTGGCAAAGGTGTTGCTGTTGTTCTCGATGTTGCTGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTGGAAGAAATGCGCACAGCAGAAGCTCAGTTAGCTTCTGGTCTCGGTGTTTCCAAT
GATGATGCGCGTGCTCAAGTACTTGGGCGCATTAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2MSY5

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8G0X0

References